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Study · Non-randomized trial · n = 74 · 2020

6 results

[Treatment of contusion of moderate severity in children in outpatient clinics].

Skripnik OY, Sumenko VV, Trusova OY, Danilova EI, Evstifeeva GY, Chelpachenko OE

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova1 Jan 2020

PMID32323940 (opens in a new tab)DOI10.17116/jnevro202012003129 (opens in a new tab)PepBankPUB-32323940
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In children with moderate brain contusion, cortexin plus standard therapy reduced subjective symptoms compared with standard therapy alone.

    In plain wordsIn children with brain contusion, cortexin plus standard therapy reduced subjective symptoms compared with standard therapy alone.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    DecreaseSubjective symptom severity
    Study

    n = 74

    Comparator
    Standard therapy without cortexin
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    There were a decrease in the severity of subjective symptoms (p<0,01) and focal neurological symptoms (p <0,001) as well as absence of acute waves to physical activity according to EEG results in the main group compared with the control group.
    2 context sentences
    Summary · context
    Seventy-four patients, aged 6-13 years, with a traumatic brain injury and a moderate brain contusion were examined.
    Summary · context
    Children of the main group received standard therapy and cortexin. Children of the control group received similar treatment without cortexin. Re-examination was carried out 30 days after the start of treatment.
  2. 02HumanNon-randomized trialEfficacy outcome

    In children with moderate brain contusion, cortexin plus standard therapy reduced focal neurological symptoms compared with standard therapy alone.

    In plain wordsIn children with brain contusion, cortexin plus standard therapy reduced focal neurological symptoms compared with standard therapy alone.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    DecreaseFocal neurological symptom severity
    Study

    n = 74

    Comparator
    Standard therapy without cortexin
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    There were a decrease in the severity of subjective symptoms (p<0,01) and focal neurological symptoms (p <0,001) as well as absence of acute waves to physical activity according to EEG results in the main group compared with the control group.
    2 context sentences
    Summary · context
    Seventy-four patients, aged 6-13 years, with a traumatic brain injury and a moderate brain contusion were examined.
    Summary · context
    Children of the main group received standard therapy and cortexin. Children of the control group received similar treatment without cortexin. Re-examination was carried out 30 days after the start of treatment.
  3. 03HumanNon-randomized trialEfficacy outcome

    In children with moderate brain contusion, the cortexin group had no acute EEG waves with physical activity compared with controls.

    In plain wordsIn children with brain contusion, the cortexin group had no acute EEG waves with physical activity compared with controls.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    DecreaseEEG acute waves with physical activity
    Study

    n = 74

    Comparator
    Standard therapy without cortexin
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    There were a decrease in the severity of subjective symptoms (p<0,01) and focal neurological symptoms (p <0,001) as well as absence of acute waves to physical activity according to EEG results in the main group compared with the control group.
    2 context sentences
    Summary · context
    Seventy-four patients, aged 6-13 years, with a traumatic brain injury and a moderate brain contusion were examined.
    Summary · context
    Children of the main group received standard therapy and cortexin. Children of the control group received similar treatment without cortexin. Re-examination was carried out 30 days after the start of treatment.

Studies that did not test the peptide alone3

In this study, Cortexin (cortical polypeptide complex) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cortexin (cortical polypeptide complex).

  1. 04HumanNot a test of Cortexin (cortical polypeptide complex) aloneNon-randomized trialEfficacy outcome

    In children with moderate brain contusion, EEG showed age-appropriate cortical electrogenesis after treatment; the abstract reports no comparison with the control group.

    In plain wordsIn children with brain contusion, EEG showed age-appropriate brain activity after treatment; no comparison with the control group is reported.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    Not applicableAge-appropriate cortical electrogenesis
    Study

    n = 74

    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    Also, EEG showed that cortical electrogenesis corresponded to the age of the patient, hypertensive/hydrocephalic signs were stopped (p <0,05), positive changes in cognitive functions occurred.
    2 context sentences
    Summary · context
    Seventy-four patients, aged 6-13 years, with a traumatic brain injury and a moderate brain contusion were examined.
    Summary · context
    Children of the main group received standard therapy and cortexin. Children of the control group received similar treatment without cortexin. Re-examination was carried out 30 days after the start of treatment.

    In this study, Cortexin (cortical polypeptide complex) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cortexin (cortical polypeptide complex).

  2. 05HumanNot a test of Cortexin (cortical polypeptide complex) aloneNon-randomized trialEfficacy outcome

    In children with moderate brain contusion, hypertensive/hydrocephalic signs stopped after treatment; the abstract reports no comparison with the control group.

    In plain wordsIn children with brain contusion, hypertensive and hydrocephalic signs stopped after treatment; no comparison with the control group is reported.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    DecreaseHypertensive/hydrocephalic signs
    Study

    n = 74

    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    Also, EEG showed that cortical electrogenesis corresponded to the age of the patient, hypertensive/hydrocephalic signs were stopped (p <0,05), positive changes in cognitive functions occurred.
    2 context sentences
    Summary · context
    Seventy-four patients, aged 6-13 years, with a traumatic brain injury and a moderate brain contusion were examined.
    Summary · context
    Children of the main group received standard therapy and cortexin. Children of the control group received similar treatment without cortexin. Re-examination was carried out 30 days after the start of treatment.

    In this study, Cortexin (cortical polypeptide complex) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cortexin (cortical polypeptide complex).

  3. 06HumanNot a test of Cortexin (cortical polypeptide complex) aloneNon-randomized trialEfficacy outcome

    In children with moderate brain contusion, cognitive functions improved after treatment; the abstract reports no comparison with the control group.

    In plain wordsIn children with brain contusion, cognitive functions improved after treatment; no comparison with the control group is reported.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    IncreaseCognitive function
    Study

    n = 74

    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    Also, EEG showed that cortical electrogenesis corresponded to the age of the patient, hypertensive/hydrocephalic signs were stopped (p <0,05), positive changes in cognitive functions occurred.
    2 context sentences
    Summary · context
    Seventy-four patients, aged 6-13 years, with a traumatic brain injury and a moderate brain contusion were examined.
    Summary · context
    Children of the main group received standard therapy and cortexin. Children of the control group received similar treatment without cortexin. Re-examination was carried out 30 days after the start of treatment.

    In this study, Cortexin (cortical polypeptide complex) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cortexin (cortical polypeptide complex).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:25 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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