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Study · Measured the body's own peptide · 2020

7 results

Exposure of female mice to perfluorooctanoic acid suppresses hypothalamic kisspeptin-reproductive endocrine system through enhanced hepatic fibroblast growth factor 21 synthesis, leading to ovulation failure and prolonged dioestrus.

Zhang Y, Cao X, Chen L, Qin Y, Xu Y, Tian Y, Chen L

Journal of neuroendocrinology19 Apr 2020Cited by 25 (Europe PMC)

PMID32307816 (opens in a new tab)DOI10.1111/jne.12848 (opens in a new tab)PepBankPUB-32307816
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In adult female mice, oral PFOA decreased the expression of kisspeptin in the anteroventral periventricular nucleus.

    In plain wordsIn mice, PFOA exposure lowered the body's own kisspeptin in a brain area that controls ovulation.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseKisspeptin expression in the AVPV after PFOA
    Study

    mousen: not reported in source

    Adult female mice given oral PFOA
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    Exposure to PFOA decreased the expression of vasopressin in the suprachiasmatic nucleus (SCN) and kisspeptin in the anteroventral periventricular nucleus (AVPV) with deficits in preovulation or oestrogen-induced LH surge.
    1 context sentence
    Summary · context
    oral administration of PFOA (2 or 5 mg kg-1 ) in adult female mice (PFOA mice)

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In PFOA-treated female mice, the PPARα antagonist GW6471 rescued kisspeptin expression in the AVPV.

    In plain wordsIn mice given PFOA, a PPARα-blocking drug restored the body's own kisspeptin in a brain area that controls ovulation.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseAVPV kisspeptin expression after GW6471 in PFOA mice
    Study

    mousen: not reported in source

    Adult female mice given oral PFOA
    Comparator
    PFOA mice without GW6471
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    Treatment of PFOA mice with the PPARα antagonist GW6471 or the FGF21 inhibitor PD173074 rescued SCN vasopressin and AVPV-kisspeptin expression.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In PFOA-treated female mice, the FGF21 inhibitor PD173074 rescued kisspeptin expression in the AVPV.

    In plain wordsIn mice given PFOA, an FGF21-blocking drug restored the body's own kisspeptin in a brain area that controls ovulation.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseAVPV kisspeptin expression after PD173074 in PFOA mice
    Study

    mousen: not reported in source

    Adult female mice given oral PFOA
    Comparator
    PFOA mice without PD173074
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    Treatment of PFOA mice with the PPARα antagonist GW6471 or the FGF21 inhibitor PD173074 rescued SCN vasopressin and AVPV-kisspeptin expression.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone4

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

  1. 04AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Efficacy outcome

    In PFOA-treated female mice, treatment with vasopressin and kisspeptin‑10 together recovered the regular oestrous cycle.

    In plain wordsIn mice given PFOA, vasopressin plus kisspeptin‑10 together restored a regular reproductive cycle. The effect of kisspeptin‑10 alone was not tested.

    Peptide
    Kisspeptin-10
    Outcome
    Direction not reportedOestrous cycle in PFOA mice after vasopressin plus kisspeptin-10
    Study

    mousen: not reported in source

    Adult female mice given oral PFOA
    Comparator
    PFOA mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Either administration of GW6471 and PD173074 or treatment with vasopressin and the G protein coupled receptor 54 agonist kisspeptin-10 in PFOA-mice was able to recover the regular oestrous cycle, ovulation ability, LH surge production and reproductive hormone levels.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

  2. 05AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Efficacy outcome

    In PFOA-treated female mice, treatment with vasopressin and kisspeptin‑10 together recovered ovulation ability.

    In plain wordsIn mice given PFOA, vasopressin plus kisspeptin‑10 together restored the ability to ovulate. The effect of kisspeptin‑10 alone was not tested.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseOvulation ability in PFOA mice after vasopressin plus kisspeptin-10
    Study

    mousen: not reported in source

    Adult female mice given oral PFOA
    Comparator
    PFOA mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Either administration of GW6471 and PD173074 or treatment with vasopressin and the G protein coupled receptor 54 agonist kisspeptin-10 in PFOA-mice was able to recover the regular oestrous cycle, ovulation ability, LH surge production and reproductive hormone levels.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

  3. 06AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Efficacy outcome

    In PFOA-treated female mice, treatment with vasopressin and kisspeptin‑10 together recovered LH surge production.

    In plain wordsIn mice given PFOA, vasopressin plus kisspeptin‑10 together restored the LH surge. The effect of kisspeptin‑10 alone was not tested.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseLH surge in PFOA mice after vasopressin plus kisspeptin-10
    Study

    mousen: not reported in source

    Adult female mice given oral PFOA
    Comparator
    PFOA mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Either administration of GW6471 and PD173074 or treatment with vasopressin and the G protein coupled receptor 54 agonist kisspeptin-10 in PFOA-mice was able to recover the regular oestrous cycle, ovulation ability, LH surge production and reproductive hormone levels.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

  4. 07AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Efficacy outcome

    In PFOA-treated female mice, treatment with vasopressin and kisspeptin‑10 together recovered reproductive hormone levels.

    In plain wordsIn mice given PFOA, vasopressin plus kisspeptin‑10 together restored reproductive hormone levels. The effect of kisspeptin‑10 alone was not tested.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseReproductive hormone levels in PFOA mice after vasopressin plus kisspeptin-10
    Study

    mousen: not reported in source

    Adult female mice given oral PFOA
    Comparator
    PFOA mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Either administration of GW6471 and PD173074 or treatment with vasopressin and the G protein coupled receptor 54 agonist kisspeptin-10 in PFOA-mice was able to recover the regular oestrous cycle, ovulation ability, LH surge production and reproductive hormone levels.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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