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Study · Animal study (in vivo) · rat · 2021

4 results

An assessment of the protective effect of gonadotropin-releasing hormone agonist and antagonist on bleomycin-induced ovarian toxicity in rats.

Atakul T, Tayyar AT, Turan ÖD, Çelik SY, Yılmaz M, Küçük M, Yüksel H, Demirci B

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology14 Apr 2020Cited by 4 (Europe PMC)

PMID32283955 (opens in a new tab)DOI10.1080/09513590.2020.1753033 (opens in a new tab)PepBankPUB-32283955
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In bleomycin-treated rats, AMH levels did not differ significantly across groups, including the triptorelin group.

    In plain wordsIn rats, AMH levels did not differ significantly across groups, including triptorelin and bleomycin alone.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeAMH levels
    Study

    ratn = 30

    bleomycin-induced ovarian toxicity in Wistar albino rats
    Comparator
    all study groups
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    1 mg/kg · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    Although AMH levels were lower in the bleomycin group than in all the other groups, there was no statistically significant difference between the groups in terms of AMH levels (p > .05).
    1 context sentence
    Summary · context
    The bleomycin + GnRH agonist group (Group III) was administered subcutaneous GnRH agonist triptorelin (1 mg/kg) at the same time as the bleomycin injections.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In bleomycin-treated rats, triptorelin increased primordial follicle counts versus bleomycin alone.

    In plain wordsIn rats, triptorelin increased primordial follicle counts compared with bleomycin alone.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreasePrimordial follicle count
    Study

    ratn: not reported in source

    bleomycin-induced ovarian toxicity in Wistar albino rats
    Comparator
    bleomycin alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    1 mg/kg · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    In the bleomycin + cetrorelix acetate and bleomycin + triptorelin groups, significantly higher primordial, secondary and tertiary follicle counts were determined compared to the bleomycin group (p < .001).
    1 context sentence
    Summary · context
    The bleomycin + GnRH agonist group (Group III) was administered subcutaneous GnRH agonist triptorelin (1 mg/kg) at the same time as the bleomycin injections.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In bleomycin-treated rats, triptorelin increased secondary follicle counts versus bleomycin alone.

    In plain wordsIn rats, triptorelin increased secondary follicle counts compared with bleomycin alone.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseSecondary follicle count
    Study

    ratn: not reported in source

    bleomycin-induced ovarian toxicity in Wistar albino rats
    Comparator
    bleomycin alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    1 mg/kg · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    In the bleomycin + cetrorelix acetate and bleomycin + triptorelin groups, significantly higher primordial, secondary and tertiary follicle counts were determined compared to the bleomycin group (p < .001).
    1 context sentence
    Summary · context
    The bleomycin + GnRH agonist group (Group III) was administered subcutaneous GnRH agonist triptorelin (1 mg/kg) at the same time as the bleomycin injections.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In bleomycin-treated rats, triptorelin increased tertiary follicle counts versus bleomycin alone.

    In plain wordsIn rats, triptorelin increased tertiary follicle counts compared with bleomycin alone.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseTertiary follicle count
    Study

    ratn: not reported in source

    bleomycin-induced ovarian toxicity in Wistar albino rats
    Comparator
    bleomycin alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    1 mg/kg · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    In the bleomycin + cetrorelix acetate and bleomycin + triptorelin groups, significantly higher primordial, secondary and tertiary follicle counts were determined compared to the bleomycin group (p < .001).
    1 context sentence
    Summary · context
    The bleomycin + GnRH agonist group (Group III) was administered subcutaneous GnRH agonist triptorelin (1 mg/kg) at the same time as the bleomycin injections.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    27 Oct 2026, 16:35 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    22 Oct 2026, 02:26 UTC

    Study results updated

  3. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

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