Hypothalamic and brain stem neurochemical profile in anorectic rats after peripheral administration of kisspeptin-10 using ¹ H-nmr spectroscopy in vivo.

Skowron K, Jasiński K, Kurnik-Łucka M, Stach P, Kalita K, Węglarz WP, Gil K

NMR in biomedicine6 Apr 2020Cited by 8 (Europe PMC)

PMID32253803DOI10.1002/nbm.4306PepBankPUB-32253803

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats in an activity-based model of anorexia, kisspeptin reinforced food consumption.
In plain wordsIn rats, kisspeptin increased food intake in a model of anorexia.
Peptide
Kisspeptin-10
Outcome
IncreaseFood consumption
Study
ratn: not reported in source
activity-based anorexia (ABA) rat model
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · subcutaneousAs given in this study (rat).
Source sentences
Summary
Kisspeptin reinforced food consumption in an activity-based rodent model of anorexia changing a pattern of weight loss.
1 context sentence(design, population, supporting numbers)
Summary · context
¹ H-NMR spectroscopy was used to measure concentrations of the hypothalamus and brain stem metabolites in an activity-based rodent model (ABA) after subcutaneous administration of kisspeptin-10.
Report a problemFND-3225380301
02AnimalAnimal study (in vivo)Efficacy outcome
In rats in an activity-based model of anorexia, kisspeptin changed the pattern of weight loss.
In plain wordsIn rats, kisspeptin changed the pattern of weight loss in a model of anorexia.
Peptide
Kisspeptin-10
Outcome
Direction not reportedPattern of weight loss
Study
ratn: not reported in source
activity-based anorexia (ABA) rat model
Outcome group
Body weight · Metabolic and weight
Studied dose
Dose not stated · subcutaneousAs given in this study (rat).
Source sentences
Summary
changing a pattern of weight loss.
1 context sentence(design, population, supporting numbers)
Summary · context
¹ H-NMR spectroscopy was used to measure concentrations of the hypothalamus and brain stem metabolites in an activity-based rodent model (ABA) after subcutaneous administration of kisspeptin-10.
Report a problemFND-3225380302
03AnimalAnimal study (in vivo)Mechanism
In rats in an activity-based model of anorexia, subcutaneous kisspeptin reversed the decrease in GABA in the hypothalamus.
In plain wordsIn rats, kisspeptin reversed a fall in the brain chemical GABA in the hypothalamus.
Peptide
Kisspeptin-10
Outcome
IncreaseHypothalamic GABA level
Study
ratn: not reported in source
activity-based anorexia (ABA) rat model
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · subcutaneousAs given in this study (rat).
Source sentences
Summary
Subcutaneous administration of kisspeptin reversed the decrease in GABA (P = 0.018) and Cr (P = 0.030) levels in the hypothalamus
1 context sentence(design, population, supporting numbers)
Summary · context
¹ H-NMR spectroscopy was used to measure concentrations of the hypothalamus and brain stem metabolites in an activity-based rodent model (ABA) after subcutaneous administration of kisspeptin-10.
Report a problemFND-3225380303
04AnimalAnimal study (in vivo)Mechanism
In rats in an activity-based model of anorexia, subcutaneous kisspeptin reversed the decrease in creatine in the hypothalamus.
In plain wordsIn rats, kisspeptin reversed a fall in creatine, an energy-related chemical, in the hypothalamus.
Peptide
Kisspeptin-10
Outcome
IncreaseHypothalamic creatine level
Study
ratn: not reported in source
activity-based anorexia (ABA) rat model
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · subcutaneousAs given in this study (rat).
Source sentences
Summary
Subcutaneous administration of kisspeptin reversed the decrease in GABA (P = 0.018) and Cr (P = 0.030) levels in the hypothalamus
1 context sentence(design, population, supporting numbers)
Summary · context
¹ H-NMR spectroscopy was used to measure concentrations of the hypothalamus and brain stem metabolites in an activity-based rodent model (ABA) after subcutaneous administration of kisspeptin-10.
Report a problemFND-3225380304
05AnimalAnimal study (in vivo)Mechanism
In rats in an activity-based model of anorexia, subcutaneous kisspeptin restored the glutamate level in the brain stem.
In plain wordsIn rats, kisspeptin restored the level of the brain chemical glutamate in the brain stem.
Peptide
Kisspeptin-10
Outcome
Direction not reportedBrain stem glutamate level
Study
ratn: not reported in source
activity-based anorexia (ABA) rat model
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · subcutaneousAs given in this study (rat).
Source sentences
Summary
as well as restored glutamate (GLU; P = 0.040) level in the brain stem.
1 context sentence(design, population, supporting numbers)
Summary · context
¹ H-NMR spectroscopy was used to measure concentrations of the hypothalamus and brain stem metabolites in an activity-based rodent model (ABA) after subcutaneous administration of kisspeptin-10.
Report a problemFND-3225380305

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

Keywords

PepBank is a research reference. Talk to a doctor before you use any peptide.