Skip to content

Study · In vitro (cells) · 2020

6 results

Purinergic Signaling Involvement in Thymosin β4-mediated Corneal Epithelial Cell Migration.

Yang HM, Kang SW, Sung J, Kim K, Kleinman H

Current eye research2 Apr 2020Cited by 10 (Europe PMC)

PMID32223337 (opens in a new tab)DOI10.1080/02713683.2020.1748891 (opens in a new tab)PepBankPUB-32223337
Source linkPubMedAsk about this study
Jump to 6 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In human corneal epithelial cells, Tβ4 enhanced proliferation in a dose- and time-dependent manner.

    In plain wordsIn cells, Tβ4 increased the growth of human corneal cells, depending on dose and time.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseHCEC proliferation
    Study

    humann: not reported in source

    human corneal epithelial cells (HCEC)
    Outcome group
    Wound healing · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Tβ4 enhanced HCEC proliferation and migration in a dose- and time-dependent manner.
    1 context sentence
    Summary · context
    Various concentrations of Tβ4 were tested in vitro on human corneal epithelial cell proliferation using the CCK-8 Kit and on cell migration using the gap closure migration assay.
  2. 02LabIn vitro (cells)Efficacy outcome

    In human corneal epithelial cells, Tβ4 enhanced migration in a dose- and time-dependent manner.

    In plain wordsIn cells, Tβ4 increased the movement of human corneal cells, depending on dose and time.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseHCEC migration
    Study

    humann: not reported in source

    human corneal epithelial cells (HCEC)
    Outcome group
    Wound healing · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Tβ4 enhanced HCEC proliferation and migration in a dose- and time-dependent manner.
    1 context sentence
    Summary · context
    Various concentrations of Tβ4 were tested in vitro on human corneal epithelial cell proliferation using the CCK-8 Kit and on cell migration using the gap closure migration assay.
  3. 03LabIn vitro (cells)Mechanism

    In human corneal epithelial cells, Tβ4 effects on proliferation and migration were related to increased extracellular ATP levels.

    In plain wordsIn cells, the Tβ4 effects on cell growth and movement were linked to higher ATP outside the cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseExtracellular ATP level
    Study

    humann: not reported in source

    human corneal epithelial cells (HCEC)
    Outcome group
    Receptor activity and mechanism · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, these functions were related to increased extracellular ATP levels, intracellular Ca2+ influx, and ERK1/2 phosphorylation.
    1 context sentence
    Summary · context
    Various concentrations of Tβ4 were tested in vitro on human corneal epithelial cell proliferation using the CCK-8 Kit and on cell migration using the gap closure migration assay.
  4. 04LabIn vitro (cells)Mechanism

    In human corneal epithelial cells, Tβ4 effects on proliferation and migration were related to increased intracellular Ca2+ influx.

    In plain wordsIn cells, the Tβ4 effects on cell growth and movement were linked to more calcium entering the cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseIntracellular Ca2+ influx
    Study

    humann: not reported in source

    human corneal epithelial cells (HCEC)
    Outcome group
    Receptor activity and mechanism · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, these functions were related to increased extracellular ATP levels, intracellular Ca2+ influx, and ERK1/2 phosphorylation.
    1 context sentence
    Summary · context
    Various concentrations of Tβ4 were tested in vitro on human corneal epithelial cell proliferation using the CCK-8 Kit and on cell migration using the gap closure migration assay.
  5. 05LabIn vitro (cells)Mechanism

    In human corneal epithelial cells, Tβ4 effects on proliferation and migration were related to increased ERK1/2 phosphorylation.

    In plain wordsIn cells, the Tβ4 effects on cell growth and movement were linked to more ERK1/2 signaling.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseERK1/2 phosphorylation
    Study

    humann: not reported in source

    human corneal epithelial cells (HCEC)
    Outcome group
    Receptor activity and mechanism · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, these functions were related to increased extracellular ATP levels, intracellular Ca2+ influx, and ERK1/2 phosphorylation.
    1 context sentence
    Summary · context
    Various concentrations of Tβ4 were tested in vitro on human corneal epithelial cell proliferation using the CCK-8 Kit and on cell migration using the gap closure migration assay.
  6. 06LabIn vitro (cells)Mechanism

    In human corneal epithelial cells, specific P2X7 purinergic receptor antagonists inhibited Tβ4-mediated migration.

    In plain wordsIn cells, drugs that block the P2X7 receptor stopped the Tβ4-driven movement of corneal cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableTβ4-mediated migration with P2X7 antagonists
    Study

    humann: not reported in source

    human corneal epithelial cells (HCEC)
    Outcome group
    Receptor activity and mechanism · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Tβ4-mediated HCEC migration was inhibited by specific P2X7 purinergic receptor antagonists suggesting the role of this receptor in Tβ4-mediated human corneal epithelial cell migration.
    1 context sentence
    Summary · context
    Various concentrations of Tβ4 were tested in vitro on human corneal epithelial cell proliferation using the CCK-8 Kit and on cell migration using the gap closure migration assay.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.