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Study · Measured the body's own peptide · 2020

3 results

Thymosin β4 Identified by Transcriptomic Analysis from HF Anagen to Telogen Promotes Proliferation of SHF-DPCs in Albas Cashmere Goat.

Dai B, Hao F, Xu T, Zhu B, Ren LQ, Han XY, Liu DJ

International journal of molecular sciences25 Mar 2020Cited by 7 (Europe PMC)

PMID32218218 (opens in a new tab)PMCIDPMC7177334 (opens in a new tab)DOI10.3390/ijms21072268 (opens in a new tab)PepBankPUB-32218218
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Summary

Increasing cashmere yield is one of the important goals of cashmere goat breeding. To achieve this goal, we screened the key genes that can improve cashmere performance. In this study, we used the RNA raw datasets of the skin and dermal papilla cells of secondary hair follicle (SHF-DPCs) samples of hair follicle (HF) anagen and telogen of Albas cashmere goats and identified a set of significant differentially expressed genes (DEGs). To explore potential associations between gene sets and SHF growth features and to identify candidate genes, we detected functional enrichment and constructed protein-protein interaction (PPI) networks. Through comprehensive analysis, we selected Thymosin β4 (Tβ4), Rho GTPase activating protein 6 (ARHGAP6), ADAM metallopeptidase with thrombospondin type 1 motif 15, (ADAMTS15), Chordin (CHRD), and SPARC (Osteonectin), cwcv and kazal-like domains proteoglycan 1 (SPOCK1) as candidate genes. Gene set enrichment analysis (GSEA) for these genes revealed Tβ4 and ARHGAP6 have a close association with the growth and development of SHF-DPCs. However, the expression of Tβ4 in the anagen was higher than that in the telogen, so we finally chose Tβ4 as the ultimate research object. Overexpressing Tβ4 promoted and silencing Tβ4 inhibited the proliferation of SHF-DPCs. These findings suggest that Tβ4 can promote the growth and development of SHF-DPCs and indicate that this molecule may be a valuable target for increasing cashmere production.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In Albas cashmere goats, Tβ4 expression in the hair follicle anagen was higher than in the telogen.

    In plain wordsIn cashmere goats, the body's own Tβ4 was higher in the hair growth phase than in the resting phase.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseTβ4 expression in anagen versus telogen
    Study

    goatn: not reported in source

    Albas cashmere goat skin, hair follicle anagen and telogen
    Outcome group
    Endogenous peptide levels · Skin and wound

    Source sentences

    Summary
    However, the expression of Tβ4 in the anagen was higher than that in the telogen, so we finally chose Tβ4 as the ultimate research object.
    1 context sentence
    Summary · context
    In this study, we used the RNA raw datasets of the skin and dermal papilla cells of secondary hair follicle (SHF-DPCs) samples of hair follicle (HF) anagen and telogen of Albas cashmere goats and identified a set of significant differentially expressed genes (DEGs).

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone2

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 02LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Efficacy outcome

    In goat secondary hair follicle dermal papilla cells, overexpressing Tβ4 promoted proliferation.

    In plain wordsIn goat cells, raising Tβ4 production increased cell growth.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseSHF-DPC proliferation with Tβ4 overexpression
    Study

    goatn: not reported in source

    Goat SHF-DPCs
    Outcome group
    Skin and hair · Skin and wound

    Source sentences

    Summary
    Overexpressing Tβ4 promoted and silencing Tβ4 inhibited the proliferation of SHF-DPCs.
    1 context sentence
    Summary · context
    In this study, we used the RNA raw datasets of the skin and dermal papilla cells of secondary hair follicle (SHF-DPCs) samples of hair follicle (HF) anagen and telogen of Albas cashmere goats and identified a set of significant differentially expressed genes (DEGs).

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  2. 03LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Efficacy outcome

    In goat secondary hair follicle dermal papilla cells, silencing Tβ4 inhibited proliferation.

    In plain wordsIn goat cells, switching off Tβ4 production reduced cell growth.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseSHF-DPC proliferation with Tβ4 silencing
    Study

    goatn: not reported in source

    Goat SHF-DPCs
    Outcome group
    Skin and hair · Skin and wound

    Source sentences

    Summary
    Overexpressing Tβ4 promoted and silencing Tβ4 inhibited the proliferation of SHF-DPCs.
    1 context sentence
    Summary · context
    In this study, we used the RNA raw datasets of the skin and dermal papilla cells of secondary hair follicle (SHF-DPCs) samples of hair follicle (HF) anagen and telogen of Albas cashmere goats and identified a set of significant differentially expressed genes (DEGs).

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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