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Study · Animal study (in vivo) · mouse · 2020

7 results

Administration of Nicotinamide Mononucleotide (NMN) Reduces Metabolic Impairment in Male Mouse Offspring from Obese Mothers.

Uddin GM, Youngson NA, Chowdhury SS, Hagan C, Sinclair DA, Morris MJ

Cells25 Mar 2020Cited by 28 (Europe PMC)

PMID32218167 (opens in a new tab)PMCIDPMC7226525 (opens in a new tab)DOI10.3390/cells9040791 (opens in a new tab)PepBankPUB-32218167
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Summary

Maternal obesity impacts offspring metabolism. We sought to boost mitochondrial energy metabolism using the nicotinamide adenine dinucleotide (NAD+) precursor nicotinamide mononucleotide (NMN) to treat metabolic impairment induced by maternal and long-term post weaning over-nutrition. Male offspring of lean or obese mothers, fed chow or high fat diet (HFD) for 30 weeks post-weaning, were given NMN injection, starting at 31 weeks of age, daily for 3 weeks before sacrifice. Glucose tolerance was tested at 10, 29 and 32 weeks of age to measure short and long term effects of post-weaning HFD, and NMN treatment. Plasma insulin and triglycerides, liver triglycerides and expression of mitochondrial metabolism-related genes were measured at 34 weeks. Impaired glucose tolerance due to maternal and post weaning HFD was significantly improved by only 8 days of NMN treatment. Furthermore, in offspring of obese mothers hepatic lipid accumulation was reduced due to NMN treatment by 50% and 23% in chow and HFD fed offspring respectively. Hepatic genes involved in fat synthesis, transport and uptake were reduced, while those involved in fatty acid oxidation were increased by NMN. Overall this finding suggests short term administration of NMN could be a therapeutic approach for treating metabolic disease due to maternal and post weaning over-nutrition, even in late adulthood.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male mouse offspring, NMN significantly improved glucose intolerance due to maternal and post-weaning high-fat diets after 8 days.

    In plain wordsIn mice, NMN improved glucose intolerance caused by maternal and post-weaning high-fat diets after 8 days.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseGlucose tolerance
    Study

    mousen: not reported in source

    male offspring exposed to maternal or post-weaning over-nutrition
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · injection · 8 daysAs given in this study (mouse).

    Source sentences

    Summary
    Impaired glucose tolerance due to maternal and post weaning HFD was significantly improved by only 8 days of NMN treatment.
    1 context sentence
    Summary · context
    Male offspring of lean or obese mothers, fed chow or high fat diet (HFD) for 30 weeks post-weaning, were given NMN injection, starting at 31 weeks of age, daily for 3 weeks before sacrifice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In chow-fed offspring of obese mothers, NMN reduced hepatic lipid accumulation by 50%.

    In plain wordsIn chow-fed mice born to obese mothers, NMN reduced liver lipid accumulation by 50%.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseHepatic lipid accumulation in chow-fed offspring
    Study

    mousen: not reported in source

    male offspring exposed to maternal or post-weaning over-nutrition
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated · injection · 3 weeksAs given in this study (mouse).

    Measurements

    Hepatic lipid reduction
    50%
    chow-fed offspring of obese mothers

    Source sentences

    Summary
    Furthermore, in offspring of obese mothers hepatic lipid accumulation was reduced due to NMN treatment by 50% and 23% in chow and HFD fed offspring respectively.
    1 context sentence
    Summary · context
    Male offspring of lean or obese mothers, fed chow or high fat diet (HFD) for 30 weeks post-weaning, were given NMN injection, starting at 31 weeks of age, daily for 3 weeks before sacrifice.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In high-fat diet-fed offspring of obese mothers, NMN reduced hepatic lipid accumulation by 23%.

    In plain wordsIn mice fed high-fat diets and born to obese mothers, NMN reduced liver lipid accumulation by 23%.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseHepatic lipid accumulation in HFD-fed offspring
    Study

    mousen: not reported in source

    male offspring exposed to maternal or post-weaning over-nutrition
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated · injection · 3 weeksAs given in this study (mouse).

    Measurements

    Hepatic lipid reduction
    23%
    HFD-fed offspring of obese mothers

    Source sentences

    Summary
    Furthermore, in offspring of obese mothers hepatic lipid accumulation was reduced due to NMN treatment by 50% and 23% in chow and HFD fed offspring respectively.
    1 context sentence
    Summary · context
    Male offspring of lean or obese mothers, fed chow or high fat diet (HFD) for 30 weeks post-weaning, were given NMN injection, starting at 31 weeks of age, daily for 3 weeks before sacrifice.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In male mouse offspring, NMN reduced hepatic genes involved in fat synthesis.

    In plain wordsIn mice, NMN reduced liver expression of genes involved in fat synthesis.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseHepatic fat synthesis gene expression
    Study

    mousen: not reported in source

    male offspring exposed to maternal or post-weaning over-nutrition
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated · injection · 3 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Hepatic genes involved in fat synthesis, transport and uptake were reduced, while those involved in fatty acid oxidation were increased by NMN.
    1 context sentence
    Summary · context
    Male offspring of lean or obese mothers, fed chow or high fat diet (HFD) for 30 weeks post-weaning, were given NMN injection, starting at 31 weeks of age, daily for 3 weeks before sacrifice.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In male mouse offspring, NMN reduced hepatic genes involved in fat transport.

    In plain wordsIn mice, NMN reduced liver expression of genes involved in fat transport.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseHepatic fat transport gene expression
    Study

    mousen: not reported in source

    male offspring exposed to maternal or post-weaning over-nutrition
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated · injection · 3 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Hepatic genes involved in fat synthesis, transport and uptake were reduced, while those involved in fatty acid oxidation were increased by NMN.
    1 context sentence
    Summary · context
    Male offspring of lean or obese mothers, fed chow or high fat diet (HFD) for 30 weeks post-weaning, were given NMN injection, starting at 31 weeks of age, daily for 3 weeks before sacrifice.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In male mouse offspring, NMN reduced hepatic genes involved in fat uptake.

    In plain wordsIn mice, NMN reduced liver expression of genes involved in fat uptake.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseHepatic fat uptake gene expression
    Study

    mousen: not reported in source

    male offspring exposed to maternal or post-weaning over-nutrition
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated · injection · 3 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Hepatic genes involved in fat synthesis, transport and uptake were reduced, while those involved in fatty acid oxidation were increased by NMN.
    1 context sentence
    Summary · context
    Male offspring of lean or obese mothers, fed chow or high fat diet (HFD) for 30 weeks post-weaning, were given NMN injection, starting at 31 weeks of age, daily for 3 weeks before sacrifice.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In male mouse offspring, NMN increased hepatic genes involved in fatty acid oxidation.

    In plain wordsIn mice, NMN increased liver expression of genes involved in fatty acid oxidation.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseHepatic fatty acid oxidation gene expression
    Study

    mousen: not reported in source

    male offspring exposed to maternal or post-weaning over-nutrition
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated · injection · 3 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Hepatic genes involved in fat synthesis, transport and uptake were reduced, while those involved in fatty acid oxidation were increased by NMN.
    1 context sentence
    Summary · context
    Male offspring of lean or obese mothers, fed chow or high fat diet (HFD) for 30 weeks post-weaning, were given NMN injection, starting at 31 weeks of age, daily for 3 weeks before sacrifice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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