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Study · Measured the body's own peptide · 2020

2 results

Humanin gene expression in fibroblast of Down syndrome subjects.

Salemi M, Ridolfo F, Salluzzo MG, Cannarrella R, Giambirtone M, Caniglia S, Tirolo C, Ferri R, Romano C

International journal of medical sciences18 Jan 2020Cited by 11 (Europe PMC)

PMID32132866 (opens in a new tab)PMCIDPMC7053358 (opens in a new tab)DOI10.7150/ijms.39145 (opens in a new tab)PepBankPUB-32132866
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Summary

Down syndrome (DS) is characterized by trisomy of chromosome 21 and peculiar phenotype. Humanin (HN) is a mitochondrial short 24-residue polypeptide whit anti-apoptotic and neuroprotective effects. In this study we evaluated HN protein expression and HN mRNA levels in cultured fibroblasts from DS patients and normal controls. Our results obtained by immunocytochemistry, western-blot and qRT-PCR analysis show a significant HN up-regulation in DS patients. These results confirm previous studies and suggest a role for HN may in the DS phenotype.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01LabEndogenous levelIn vitro (cells)Other

    Humanin protein expression was higher in cultured fibroblasts from patients with Down syndrome than in normal controls.

    In plain wordsIn lab-grown skin cells from Down syndrome donors, the body's own humanin protein was higher than in control cells.

    Peptide
    Humanin
    Outcome
    IncreaseHumanin protein expression in fibroblasts
    Study

    humann: not reported in source

    cultured fibroblasts from DS patients and normal controls
    Comparator
    Normal controls
    Outcome group
    Mitochondrial function · Whole body

    Source sentences

    Summary
    Our results obtained by immunocytochemistry, western-blot and qRT-PCR analysis show a significant HN up-regulation in DS patients.
    1 context sentence
    Summary · context
    In this study we evaluated HN protein expression and HN mRNA levels in cultured fibroblasts from DS patients and normal controls.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02LabEndogenous levelIn vitro (cells)Other

    Humanin mRNA levels were higher in cultured fibroblasts from patients with Down syndrome than in normal controls.

    In plain wordsIn lab-grown skin cells from Down syndrome donors, the body's own humanin mRNA was higher than in control cells.

    Peptide
    Humanin
    Outcome
    IncreaseHumanin mRNA levels in fibroblasts
    Study

    humann: not reported in source

    cultured fibroblasts from DS patients and normal controls
    Comparator
    Normal controls
    Outcome group
    Mitochondrial function · Whole body

    Source sentences

    Summary
    Our results obtained by immunocytochemistry, western-blot and qRT-PCR analysis show a significant HN up-regulation in DS patients.
    1 context sentence
    Summary · context
    In this study we evaluated HN protein expression and HN mRNA levels in cultured fibroblasts from DS patients and normal controls.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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