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Study · Not a test of the peptide alone · 2020

2 results

Xanthine oxidoreductase knockout mice with high HPRT activity were not rescued by NAD+ replenishment.

Hosoyamada M, Tomioka NH, Ohtsubo T, Ichida K

Nucleosides, nucleotides & nucleic acids4 Mar 2020Cited by 6 (Europe PMC)

PMID32126884 (opens in a new tab)DOI10.1080/15257770.2020.1725044 (opens in a new tab)PepBankPUB-32126884
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking NAD+ (nicotinamide adenine dinucleotide).

  1. 01AnimalNot a test of NAD+ (nicotinamide adenine dinucleotide) aloneAnimal study (in vivo)Efficacy outcome

    In high-HPRT/Uox-KO/Xor-KO mice, oral tryptophan for NAD+ replenishment restored body weight gain.

    In plain wordsIn mice, tryptophan used for NAD+ replenishment restored body weight gain.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    IncreaseBody weight gain
    Study

    mousen: not reported in source

    High-HPRT Xor knockout mice
    Outcome group
    Body weight · Metabolic and weight

    Source sentences

    Summary
    For NAD+ replenishment, oral supplementation with 1% L-tryptophan, an alternative precursor of NAD+, resulted in a recovery of body weight gain in high-HPRT/Uox-KO/Xor-KO mice.

    In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NAD+ (nicotinamide adenine dinucleotide).

  2. 02AnimalNot a test of NAD+ (nicotinamide adenine dinucleotide) aloneAnimal study (in vivo)Efficacy outcome

    In high-HPRT/Xor-KO mice, NAD+ replenishment with NMN or tryptophan failed to rescue the animals.

    In plain wordsIn mice, NAD+ replenishment with NMN or tryptophan failed to rescue the animals.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    Direction not reportedRescue of knockout mice
    Study

    mousen: not reported in source

    High-HPRT Xor knockout mice
    Outcome group
    Mortality · Whole body

    Source sentences

    Summary
    NAD+ replenishment by oral supplementation of NMN or tryptophan was complicated by the effect of gut microbiota and failed to rescue high-HPRT/Xor-KO mice.

    In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NAD+ (nicotinamide adenine dinucleotide).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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