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Study · In vitro (cells) · rat · 2020

2 results

Resveratrol protects against ethanol-induced impairment of insulin secretion in INS-1 cells through SIRT1-UCP2 axis.

Luo G, Xiao L, Wang D, Wang N, Luo C, Yang X, Hao L

Toxicology in vitro : an international journal published in association with BIBRA20 Feb 2020Cited by 24 (Europe PMC)

PMID32087266 (opens in a new tab)DOI10.1016/j.tiv.2020.104808 (opens in a new tab)PepBankPUB-32087266
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In INS-1 cells, NMN counteracted the deleterious effects of ethanol.

    In plain wordsIn cells, NMN counteracted ethanol's harmful effects compared with ethanol exposure without NMN.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseEthanol-induced cellular impairment
    Study

    ratn: not reported in source

    INS-1 pancreatic beta-cell line
    Comparator
    Ethanol exposure without NMN
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Meanwhile, NAD+ booster nicotinamide mononucleotide also counteracted the deleterious effects of ethanol by increasing SIRT1, suggesting the regulation of SIRT1-UCP2 axis may be associated with cellular NAD+/NADH ratio.
    1 context sentence
    Summary · context
    INS-1 cells (rat pancreatic β-cell line) were cultured with ethanol in the presence or absence of resveratrol (2.5, 12.5 μmol/L).
  2. 02LabIn vitro (cells)Mechanism

    In ethanol-exposed INS-1 cells, NMN increased SIRT1.

    In plain wordsIn cells exposed to ethanol, NMN increased SIRT1 compared with ethanol exposure without NMN.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseSIRT1 expression
    Study

    ratn: not reported in source

    INS-1 pancreatic beta-cell line
    Comparator
    Ethanol exposure without NMN
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Meanwhile, NAD+ booster nicotinamide mononucleotide also counteracted the deleterious effects of ethanol by increasing SIRT1, suggesting the regulation of SIRT1-UCP2 axis may be associated with cellular NAD+/NADH ratio.
    1 context sentence
    Summary · context
    INS-1 cells (rat pancreatic β-cell line) were cultured with ethanol in the presence or absence of resveratrol (2.5, 12.5 μmol/L).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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