Skip to content

Study · Animal study (in vivo) · mouse · 2020

7 results

Teduglutide Promotes Epithelial Tight Junction Pore Function in Murine Short Bowel Syndrome to Alleviate Intestinal Insufficiency.

Reiner J, Berlin P, Wobar J, Schäffler H, Bannert K, Bastian M, Vollmar B, Jaster R, Lamprecht G, Witte M

Digestive diseases and sciences19 Feb 2020Cited by 21 (Europe PMC)

PMID32072437 (opens in a new tab)PMCIDPMC7661426 (opens in a new tab)DOI10.1007/s10620-020-06140-6 (opens in a new tab)PepBankPUB-32072437
Read at sourcePubMedAsk about this study
Jump to 7 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In Nod2 knockout mice with short bowel syndrome, teduglutide reduced intestinal failure incidence versus vehicle.

    In plain wordsIn Nod2 knockout mice with short bowel syndrome, teduglutide reduced intestinal failure versus vehicle.

    Peptide
    Teduglutide
    Outcome
    DecreaseIntestinal failure incidence
    Study

    mousen: not reported in source

    Short bowel syndrome after 40% ICR
    Comparator
    Vehicle injections
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Teduglutide reduced intestinal failure incidence in Nod2 k.o. mice.
    2 context sentences
    Summary · context
    Mice underwent 40% ICR and were thereafter treated with Teduglutide versus vehicle injections.
    Summary · context
    Intestinal and kidney tissue was examined with light and fluorescence microscopy, Ussing chamber studies and quantitative PCR in wild type and transgenic mice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In wild-type mice with short bowel syndrome, teduglutide reduced body weight loss versus vehicle.

    In plain wordsIn wild-type mice with short bowel syndrome, teduglutide reduced weight loss versus vehicle.

    Peptide
    Teduglutide
    Outcome
    DecreaseBody weight loss
    Study

    mousen: not reported in source

    Short bowel syndrome after 40% ICR
    Comparator
    Vehicle injections
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In wt mice, Teduglutide attenuated intestinal insufficiency as indicated by reduced body weight loss and lower plasma aldosterone concentrations, lower stool water content, and lower stool sodium losses.
    2 context sentences
    Summary · context
    Mice underwent 40% ICR and were thereafter treated with Teduglutide versus vehicle injections.
    Summary · context
    Intestinal and kidney tissue was examined with light and fluorescence microscopy, Ussing chamber studies and quantitative PCR in wild type and transgenic mice.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In wild-type mice with short bowel syndrome, teduglutide lowered plasma aldosterone versus vehicle.

    In plain wordsIn wild-type mice with short bowel syndrome, teduglutide lowered blood aldosterone versus vehicle.

    Peptide
    Teduglutide
    Outcome
    DecreasePlasma aldosterone
    Study

    mousen: not reported in source

    Short bowel syndrome after 40% ICR
    Comparator
    Vehicle injections
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In wt mice, Teduglutide attenuated intestinal insufficiency as indicated by reduced body weight loss and lower plasma aldosterone concentrations, lower stool water content, and lower stool sodium losses.
    2 context sentences
    Summary · context
    Mice underwent 40% ICR and were thereafter treated with Teduglutide versus vehicle injections.
    Summary · context
    Intestinal and kidney tissue was examined with light and fluorescence microscopy, Ussing chamber studies and quantitative PCR in wild type and transgenic mice.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In wild-type mice with short bowel syndrome, teduglutide lowered stool water content versus vehicle.

    In plain wordsIn wild-type mice with short bowel syndrome, teduglutide lowered stool water content versus vehicle.

    Peptide
    Teduglutide
    Outcome
    DecreaseStool water content
    Study

    mousen: not reported in source

    Short bowel syndrome after 40% ICR
    Comparator
    Vehicle injections
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In wt mice, Teduglutide attenuated intestinal insufficiency as indicated by reduced body weight loss and lower plasma aldosterone concentrations, lower stool water content, and lower stool sodium losses.
    2 context sentences
    Summary · context
    Mice underwent 40% ICR and were thereafter treated with Teduglutide versus vehicle injections.
    Summary · context
    Intestinal and kidney tissue was examined with light and fluorescence microscopy, Ussing chamber studies and quantitative PCR in wild type and transgenic mice.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In wild-type mice with short bowel syndrome, teduglutide lowered stool sodium losses versus vehicle.

    In plain wordsIn wild-type mice with short bowel syndrome, teduglutide lowered sodium loss in stools versus vehicle.

    Peptide
    Teduglutide
    Outcome
    DecreaseStool sodium losses
    Study

    mousen: not reported in source

    Short bowel syndrome after 40% ICR
    Comparator
    Vehicle injections
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In wt mice, Teduglutide attenuated intestinal insufficiency as indicated by reduced body weight loss and lower plasma aldosterone concentrations, lower stool water content, and lower stool sodium losses.
    2 context sentences
    Summary · context
    Mice underwent 40% ICR and were thereafter treated with Teduglutide versus vehicle injections.
    Summary · context
    Intestinal and kidney tissue was examined with light and fluorescence microscopy, Ussing chamber studies and quantitative PCR in wild type and transgenic mice.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In mice with short bowel syndrome, teduglutide enhanced epithelial paracellular pore function versus vehicle.

    In plain wordsIn mice with short bowel syndrome, teduglutide enhanced epithelial pore function versus vehicle.

    Peptide
    Teduglutide
    Outcome
    IncreaseEpithelial paracellular pore function
    Study

    mousen: not reported in source

    Short bowel syndrome after 40% ICR
    Comparator
    Vehicle injections
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Teduglutide treatment was associated with enhanced epithelial paracellular pore function and enhanced claudin-10 expression in tight junctions in the villus tips, where it colocalized with sodium-glucose cotransporter 1 (SGLT-1), which mediates Na-coupled glucose transport.
    2 context sentences
    Summary · context
    Mice underwent 40% ICR and were thereafter treated with Teduglutide versus vehicle injections.
    Summary · context
    Intestinal and kidney tissue was examined with light and fluorescence microscopy, Ussing chamber studies and quantitative PCR in wild type and transgenic mice.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In mice with short bowel syndrome, teduglutide enhanced claudin-10 expression in villus-tip tight junctions versus vehicle.

    In plain wordsIn mice with short bowel syndrome, teduglutide increased claudin-10 expression in villus-tip junctions versus vehicle.

    Peptide
    Teduglutide
    Outcome
    IncreaseTight junction claudin-10 expression
    Study

    mousen: not reported in source

    Short bowel syndrome after 40% ICR
    Comparator
    Vehicle injections
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Teduglutide treatment was associated with enhanced epithelial paracellular pore function and enhanced claudin-10 expression in tight junctions in the villus tips, where it colocalized with sodium-glucose cotransporter 1 (SGLT-1), which mediates Na-coupled glucose transport.
    2 context sentences
    Summary · context
    Mice underwent 40% ICR and were thereafter treated with Teduglutide versus vehicle injections.
    Summary · context
    Intestinal and kidney tissue was examined with light and fluorescence microscopy, Ussing chamber studies and quantitative PCR in wild type and transgenic mice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.