In obese adults with prediabetes or early type 2 diabetes, liraglutide increased short term memory more than lifestyle counseling at comparable weight loss.
In plain wordsIn obese adults with prediabetes or early type 2 diabetes, liraglutide improved short term memory more than lifestyle counseling, at the same weight loss.
- Peptide
- Liraglutide
- Outcome
- IncreaseShort term memory (Digit Span Z score)
- Study
n = 32
- Comparator
- Lifestyle counseling (diet and exercise)
- Outcome group
- Cognition and memory · Nervous system and cognition
- Studied dose
- 1.8 mg/dAs given in this study (human).
Source sentences
After comparable weight loss and superimposable glycemic control and insulin sensitivity, a significant increase in short term memory (mean Digit Span Z score from -0.06 to 0.80, p = 0.024) and memory composite z-score (mean memory z-score from -0.67 to 0.032, p = 0.0065) was observed in the liraglu…
2 context sentences(design, population, supporting numbers)
Forty metformin-treated obese subjects with prediabetes or newly diagnosed type 2 diabetes mellitus, received liraglutide (1.8 mg/d) (n = 20) or lifestyle counseling (dietary intervention and exercise training) (n = 20) until achieving a modest and comparable weight loss (-7% of initial body weight).
A detailed neuropsychological assessment before and after weight loss was completed in 16 patients per arm, who were administered a total of seven psychological tests, thus assessing three composite domain z-scores for attention, memory, and executive control.