Antiviral activity of sertindole, raloxifene and ibutamoren against transcription and replication-competent Ebola virus-like particles.

Yoon YS, Jang Y, Hoenen T, Shin H, Lee Y, Kim M

BMB reports1 Mar 2020Cited by 10 (Europe PMC)

PMID31964466PMCIDPMC7118351PepBankPUB-31964466

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Activity measurement
In cells, ibutamoren showed prominent antiviral effects against Ebola trVLPs.
In plain wordsIn cells, ibutamoren showed antiviral effects against Ebola virus-like particles.
Peptide
MK-677 (ibutamoren)
Outcome
DecreaseAntiviral effects
Study
n: not reported in source
Ebola trVLP system
Outcome group
Antiviral activity · Infection
Studied dose
Dose not stated
Source sentences
Summary
The third group included sertindole, raloxifene, and ibutamoren showing prominent antiviral effects in cells.
1 context sentence(design, population, supporting numbers)
Summary · context
A chemical library comprising 2,354 drug-like compounds was screened using a transcription and replication-competent viruslike particle (trVLP) system implementing the whole Ebola virus (EBOV) life cycle.
Report a problemFND-3196446601
02LabIn vitro (cells)Activity measurement
In cells, ibutamoren reduced expression of the Ebola VP40 matrix protein.
In plain wordsIn cells, ibutamoren reduced Ebola VP40 protein expression.
Peptide
MK-677 (ibutamoren)
Outcome
DecreaseVP40 expression
Study
n: not reported in source
Ebola trVLP system
Outcome group
Antiviral activity · Infection
Studied dose
Dose not stated
Source sentences
Summary
They downregulated the expression of viral proteins, including the VP40 matrix protein and the envelope glycoprotein.
2 context sentences(design, population, supporting numbers)
Summary · context
The third group included sertindole, raloxifene, and ibutamoren showing prominent antiviral effects in cells.
Summary · context
A chemical library comprising 2,354 drug-like compounds was screened using a transcription and replication-competent viruslike particle (trVLP) system implementing the whole Ebola virus (EBOV) life cycle.
Report a problemFND-3196446602
03LabIn vitro (cells)Activity measurement
In cells, ibutamoren reduced expression of the Ebola envelope glycoprotein.
In plain wordsIn cells, ibutamoren reduced Ebola envelope protein expression.
Peptide
MK-677 (ibutamoren)
Outcome
DecreaseEnvelope glycoprotein expression
Study
n: not reported in source
Ebola trVLP system
Outcome group
Antiviral activity · Infection
Studied dose
Dose not stated
Source sentences
Summary
They downregulated the expression of viral proteins, including the VP40 matrix protein and the envelope glycoprotein.
2 context sentences(design, population, supporting numbers)
Summary · context
The third group included sertindole, raloxifene, and ibutamoren showing prominent antiviral effects in cells.
Summary · context
A chemical library comprising 2,354 drug-like compounds was screened using a transcription and replication-competent viruslike particle (trVLP) system implementing the whole Ebola virus (EBOV) life cycle.
Report a problemFND-3196446603
04LabIn vitro (cells)Activity measurement
In cells, ibutamoren reduced Ebola-derived minigenome RNA incorporated into progeny trVLPs in culture supernatant.
In plain wordsIn cells, ibutamoren reduced viral minigenome RNA inside newly produced Ebola virus-like particles.
Peptide
MK-677 (ibutamoren)
Outcome
DecreaseProgeny trVLP minigenome RNA
Study
n: not reported in source
Ebola trVLP system
Outcome group
Antiviral activity · Infection
Studied dose
Dose not stated
Source sentences
Summary
They also reduced the amount of EBOV-derived tetracistronic minigenome RNA incorporated into progeny trVLPs in the culture supernatant.
2 context sentences(design, population, supporting numbers)
Summary · context
The third group included sertindole, raloxifene, and ibutamoren showing prominent antiviral effects in cells.
Summary · context
A chemical library comprising 2,354 drug-like compounds was screened using a transcription and replication-competent viruslike particle (trVLP) system implementing the whole Ebola virus (EBOV) life cycle.
Report a problemFND-3196446604
05LabIn vitro (cells)Activity measurement
In cells, ibutamoren had a 50% effective antiviral concentration of 0.2 μM.
In plain wordsIn cells, ibutamoren's half-maximal effective antiviral concentration was 0.2 μM.
Peptide
MK-677 (ibutamoren)
Outcome
Not applicableAntiviral effective concentration
Study
n: not reported in source
Ebola trVLP system
Outcome group
Antiviral activity · Infection
Studied dose
Dose not stated
Source sentences
Summary
Particularly, ibutamoren, which is a known agonist of growth hormone secretagogue receptor (GHSR), showed the most promising antiviral activity with a 50% effective concentration of 0.2 μM, a 50% cytotoxic concentration of 42.4 μM, and a selectivity index of 222.8.
1 context sentence(design, population, supporting numbers)
Summary · context
A chemical library comprising 2,354 drug-like compounds was screened using a transcription and replication-competent viruslike particle (trVLP) system implementing the whole Ebola virus (EBOV) life cycle.
Report a problemFND-3196446605
06LabIn vitro (cells)Safety outcome
In cells, ibutamoren had a 50% cytotoxic concentration of 42.4 μM.
In plain wordsIn cells, ibutamoren's half-maximal toxic concentration was 42.4 μM.
Peptide
MK-677 (ibutamoren)
Outcome
Not applicableCytotoxic concentration
Study
n: not reported in source
Ebola trVLP system
Outcome group
Antiviral activity · Infection
Studied dose
Dose not stated
Source sentences
Summary
Particularly, ibutamoren, which is a known agonist of growth hormone secretagogue receptor (GHSR), showed the most promising antiviral activity with a 50% effective concentration of 0.2 μM, a 50% cytotoxic concentration of 42.4 μM, and a selectivity index of 222.8.
1 context sentence(design, population, supporting numbers)
Summary · context
A chemical library comprising 2,354 drug-like compounds was screened using a transcription and replication-competent viruslike particle (trVLP) system implementing the whole Ebola virus (EBOV) life cycle.
Report a problemFND-3196446606
07LabIn vitro (cells)Activity measurement
In cells, ibutamoren had an antiviral selectivity index of 222.8.
In plain wordsIn cells, ibutamoren had an antiviral selectivity index of 222.8.
Peptide
MK-677 (ibutamoren)
Outcome
Not applicableSelectivity index
Study
n: not reported in source
Ebola trVLP system
Outcome group
Antiviral activity · Infection
Studied dose
Dose not stated
Source sentences
Summary
Particularly, ibutamoren, which is a known agonist of growth hormone secretagogue receptor (GHSR), showed the most promising antiviral activity with a 50% effective concentration of 0.2 μM, a 50% cytotoxic concentration of 42.4 μM, and a selectivity index of 222.8.
1 context sentence(design, population, supporting numbers)
Summary · context
A chemical library comprising 2,354 drug-like compounds was screened using a transcription and replication-competent viruslike particle (trVLP) system implementing the whole Ebola virus (EBOV) life cycle.
Report a problemFND-3196446607

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

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