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Study · Animal study (in vivo) · mouse · 2020

9 results

SS31, a mitochondrially targeted antioxidant, prevents sepsis-induced reductions in diaphragm strength and endurance.

Supinski GS, Wang L, Schroder EA, Callahan LAP

Journal of applied physiology (Bethesda, Md. : 1985)16 Jan 2020Cited by 15 (Europe PMC)

PMID31944887 (opens in a new tab)PMCIDPMC7099438 (opens in a new tab)DOI10.1152/japplphysiol.00240.2019 (opens in a new tab)PepBankPUB-31944887
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with sepsis, SS31 prevented the fall in diaphragm force generation.

    In plain wordsIn mice with sepsis, SS31 prevented the loss of diaphragm muscle force that sepsis caused.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseDiaphragm specific force (muscle-field stimulation)
    Study

    mousen: not reported in source

    Sepsis by cecal ligation puncture (CLP)
    Comparator
    CLP
    Outcome group
    Exercise and physical function · Respiratory
    Studied dose
    10 mg/kg/dayAs given in this study (mouse).

    Measurements

    Diaphragm specific force
    27.9 N/cm2
    CLP+SS31
    Diaphragm specific force
    9.4 N/cm2
    CLP

    Source sentences

    Summary
    Diaphragm-specific force generation averaged 30.2 ± 1.4, 9.4 ± 1.8, 25.5 ± 2.3, and 27.9 ± 0.6 N/cm2 for sham, CLP, sham+SS31, and CLP+SS31 groups (P < 0.001).
    2 context sentences
    Summary · context
    Sepsis markedly reduced diaphragm force generation; SS31 prevented these decrements.
    Summary · context
    Four groups of mice were studied: 1) sham-operated controls, 2) sham-operated+SS31 (10 mg·kg-1·day-1), 3) cecal ligation puncture (CLP), and 4) CLP+SS31.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with sepsis, SS31 prevented the fall in nerve-stimulated diaphragm force generation.

    In plain wordsIn mice with sepsis, SS31 prevented the loss of nerve-driven diaphragm force.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseDiaphragm force with phrenic nerve stimulation
    Study

    mousen: not reported in source

    Sepsis by cecal ligation puncture (CLP)
    Comparator
    CLP
    Outcome group
    Exercise and physical function · Respiratory
    Studied dose
    10 mg/kg/dayAs given in this study (mouse).

    Source sentences

    Summary
    Similarly, with phrenic nerve stimulation, CLP depressed diaphragm force generation, effects prevented by SS31.
    1 context sentence
    Summary · context
    Four groups of mice were studied: 1) sham-operated controls, 2) sham-operated+SS31 (10 mg·kg-1·day-1), 3) cecal ligation puncture (CLP), and 4) CLP+SS31.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with sepsis, SS31 prevented the fall in diaphragm force during endurance trials.

    In plain wordsIn mice with sepsis, SS31 prevented the fall in diaphragm endurance.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseDiaphragm force during endurance trials
    Study

    mousen: not reported in source

    Sepsis by cecal ligation puncture (CLP)
    Comparator
    CLP
    Outcome group
    Exercise and physical function · Respiratory
    Studied dose
    10 mg/kg/dayAs given in this study (mouse).

    Source sentences

    Summary
    During endurance trials, force was significantly reduced with CLP, and SS31 prevented these reductions (P < 0.001).
    1 context sentence
    Summary · context
    Four groups of mice were studied: 1) sham-operated controls, 2) sham-operated+SS31 (10 mg·kg-1·day-1), 3) cecal ligation puncture (CLP), and 4) CLP+SS31.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice with sepsis, SS31 prevented the sepsis-induced rise in diaphragm calpain activity.

    In plain wordsIn mice with sepsis, SS31 prevented a rise in an enzyme that breaks down muscle protein.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseDiaphragm calpain activity
    Study

    mousen: not reported in source

    Sepsis by cecal ligation puncture (CLP)
    Comparator
    CLP
    Outcome group
    Muscle injury and repair · Respiratory
    Studied dose
    10 mg/kg/dayAs given in this study (mouse).

    Source sentences

    Summary
    Sepsis also increased diaphragm calpain activity, increased 20S proteasomal activity, decreased MHC levels, reduced mitochondrial function (state 3 rates and ATP generation), and reduced aconitase activity; SS31 prevented each of these sepsis-induced alterations (P ≤ 0.017 for all indices).
    1 context sentence
    Summary · context
    Four groups of mice were studied: 1) sham-operated controls, 2) sham-operated+SS31 (10 mg·kg-1·day-1), 3) cecal ligation puncture (CLP), and 4) CLP+SS31.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice with sepsis, SS31 prevented the sepsis-induced rise in diaphragm 20S proteasomal activity.

    In plain wordsIn mice with sepsis, SS31 prevented a rise in muscle protein breakdown activity.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseDiaphragm 20S proteasomal activity
    Study

    mousen: not reported in source

    Sepsis by cecal ligation puncture (CLP)
    Comparator
    CLP
    Outcome group
    Muscle injury and repair · Respiratory
    Studied dose
    10 mg/kg/dayAs given in this study (mouse).

    Source sentences

    Summary
    Sepsis also increased diaphragm calpain activity, increased 20S proteasomal activity, decreased MHC levels, reduced mitochondrial function (state 3 rates and ATP generation), and reduced aconitase activity; SS31 prevented each of these sepsis-induced alterations (P ≤ 0.017 for all indices).
    1 context sentence
    Summary · context
    Four groups of mice were studied: 1) sham-operated controls, 2) sham-operated+SS31 (10 mg·kg-1·day-1), 3) cecal ligation puncture (CLP), and 4) CLP+SS31.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In mice with sepsis, SS31 prevented the sepsis-induced fall in diaphragm myosin heavy chain levels.

    In plain wordsIn mice with sepsis, SS31 prevented loss of a key muscle protein in the diaphragm.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseDiaphragm myosin heavy chain levels
    Study

    mousen: not reported in source

    Sepsis by cecal ligation puncture (CLP)
    Comparator
    CLP
    Outcome group
    Muscle injury and repair · Respiratory
    Studied dose
    10 mg/kg/dayAs given in this study (mouse).

    Source sentences

    Summary
    Sepsis also increased diaphragm calpain activity, increased 20S proteasomal activity, decreased MHC levels, reduced mitochondrial function (state 3 rates and ATP generation), and reduced aconitase activity; SS31 prevented each of these sepsis-induced alterations (P ≤ 0.017 for all indices).
    1 context sentence
    Summary · context
    Four groups of mice were studied: 1) sham-operated controls, 2) sham-operated+SS31 (10 mg·kg-1·day-1), 3) cecal ligation puncture (CLP), and 4) CLP+SS31.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In mice with sepsis, SS31 prevented the sepsis-induced fall in diaphragm mitochondrial state 3 rates.

    In plain wordsIn mice with sepsis, SS31 prevented a fall in diaphragm mitochondrial respiration.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseDiaphragm mitochondrial state 3 rates
    Study

    mousen: not reported in source

    Sepsis by cecal ligation puncture (CLP)
    Comparator
    CLP
    Outcome group
    Mitochondrial function · Respiratory
    Studied dose
    10 mg/kg/dayAs given in this study (mouse).

    Source sentences

    Summary
    Sepsis also increased diaphragm calpain activity, increased 20S proteasomal activity, decreased MHC levels, reduced mitochondrial function (state 3 rates and ATP generation), and reduced aconitase activity; SS31 prevented each of these sepsis-induced alterations (P ≤ 0.017 for all indices).
    1 context sentence
    Summary · context
    Four groups of mice were studied: 1) sham-operated controls, 2) sham-operated+SS31 (10 mg·kg-1·day-1), 3) cecal ligation puncture (CLP), and 4) CLP+SS31.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In mice with sepsis, SS31 prevented the sepsis-induced fall in diaphragm mitochondrial ATP generation.

    In plain wordsIn mice with sepsis, SS31 prevented a fall in diaphragm energy (ATP) production.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseDiaphragm mitochondrial ATP generation
    Study

    mousen: not reported in source

    Sepsis by cecal ligation puncture (CLP)
    Comparator
    CLP
    Outcome group
    Mitochondrial function · Respiratory
    Studied dose
    10 mg/kg/dayAs given in this study (mouse).

    Source sentences

    Summary
    Sepsis also increased diaphragm calpain activity, increased 20S proteasomal activity, decreased MHC levels, reduced mitochondrial function (state 3 rates and ATP generation), and reduced aconitase activity; SS31 prevented each of these sepsis-induced alterations (P ≤ 0.017 for all indices).
    1 context sentence
    Summary · context
    Four groups of mice were studied: 1) sham-operated controls, 2) sham-operated+SS31 (10 mg·kg-1·day-1), 3) cecal ligation puncture (CLP), and 4) CLP+SS31.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In mice with sepsis, SS31 prevented the sepsis-induced fall in diaphragm aconitase activity, an index of mitochondrial superoxide generation.

    In plain wordsIn mice with sepsis, SS31 prevented a fall in aconitase activity, a marker of mitochondrial oxidative stress.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseDiaphragm aconitase activity
    Study

    mousen: not reported in source

    Sepsis by cecal ligation puncture (CLP)
    Comparator
    CLP
    Outcome group
    Mitochondrial function · Respiratory
    Studied dose
    10 mg/kg/dayAs given in this study (mouse).

    Source sentences

    Summary
    Sepsis also increased diaphragm calpain activity, increased 20S proteasomal activity, decreased MHC levels, reduced mitochondrial function (state 3 rates and ATP generation), and reduced aconitase activity; SS31 prevented each of these sepsis-induced alterations (P ≤ 0.017 for all indices).
    2 context sentences
    Summary · context
    We also measured calpain activity, 20S proteasomal activity, myosin heavy chain (MHC) levels, mitochondrial function, and aconitase activity, an index of mitochondrial superoxide generation.
    Summary · context
    Four groups of mice were studied: 1) sham-operated controls, 2) sham-operated+SS31 (10 mg·kg-1·day-1), 3) cecal ligation puncture (CLP), and 4) CLP+SS31.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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