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Study · Not a test of the peptide alone · 2019

2 results

The Overexpression of Tβ4 in the Hair Follicle Tissue of Alpas Cashmere Goats Increases Cashmere Yield and Promotes Hair Follicle Development.

Dai B, Liang H, Guo DD, Bi ZW, Yuan JL, Jin Y, Huan L, Guo XD, Cang M, Liu DJ

Animals : an open access journal from MDPI31 Dec 2019Cited by 18 (Europe PMC)

PMID31906185 (opens in a new tab)PMCIDPMC7022706 (opens in a new tab)DOI10.3390/ani10010075 (opens in a new tab)PepBankPUB-31906185
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Summary

Increased cashmere yield and improved quality are some goals of cashmere goat breeding. Thymosin beta-4 (Tβ4) plays a key role in the growth and development of hair follicles. For the past ten years, we have evaluated the role of Tβ4 by establishing a flock of 15 cashmere goats that specifically overexpress the Tβ4 gene in the hair follicles. These Tβ4 overexpression (Tβ4-OE) cashmere goats had more secondary hair follicles than the WT goats and produced more cashmere. Meanwhile, combined analysis of the skin transcriptome and proteome in cashmere goats suggested that Tβ4 may affect hair growth by interacting with keratin type II cytoskeletal 4 epidermal (KRT4) to mediate the extracellular signal-regulated protein kinase (ERK) signaling pathway, thereby promoting the development of secondary hair follicles, and consequently, increasing cashmere yield. Thus, the specific overexpression of Tβ4 in the hair follicles of cashmere goats effectively increased the cashmere yield.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 01AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    Cashmere goats overexpressing Tβ4 in hair follicles had more secondary hair follicles than wild-type goats.

    In plain wordsCashmere goats with raised Tβ4 gene activity in hair follicles had more secondary hair follicles than normal goats.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseNumber of secondary hair follicles
    Study

    cashmere goatn: not reported in source

    Tβ4 overexpression (Tβ4-OE) in hair follicles
    Comparator
    Wild-type (WT) goats
    Outcome group
    Skin and hair · Skin and wound

    Source sentences

    Summary
    These Tβ4 overexpression (Tβ4-OE) cashmere goats had more secondary hair follicles than the WT goats and produced more cashmere.
    1 context sentence
    Summary · context
    For the past ten years, we have evaluated the role of Tβ4 by establishing a flock of 15 cashmere goats that specifically overexpress the Tβ4 gene in the hair follicles.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  2. 02AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    Cashmere goats overexpressing Tβ4 in hair follicles produced more cashmere than wild-type goats.

    In plain wordsCashmere goats with raised Tβ4 gene activity in hair follicles produced more cashmere than normal goats.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseCashmere yield
    Study

    cashmere goatn: not reported in source

    Tβ4 overexpression (Tβ4-OE) in hair follicles
    Comparator
    Wild-type (WT) goats
    Outcome group
    Skin and hair · Skin and wound

    Source sentences

    Summary
    These Tβ4 overexpression (Tβ4-OE) cashmere goats had more secondary hair follicles than the WT goats and produced more cashmere.
    1 context sentence
    Summary · context
    For the past ten years, we have evaluated the role of Tβ4 by establishing a flock of 15 cashmere goats that specifically overexpress the Tβ4 gene in the hair follicles.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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