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Study · Not a test of the peptide alone · 2020

3 results

Overexpression of the histidine triad nucleotide-binding protein 2 protects cardiac function in the adult mice after acute myocardial infarction.

Fan M, Chen Z, Huang Y, Xia Y, Chen A, Lu D, Wu Y, Zhang N, Zhang P, Li S, Chen J, Zhang Y and 5 more

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Sun A, Zou Y, Hu K, Qian J, Ge J

Acta physiologica (Oxford, England)21 Jan 2020Cited by 16 (Europe PMC)

PMID31900976 (opens in a new tab)DOI10.1111/apha.13439 (opens in a new tab)PepBankPUB-31900976
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking NMN (nicotinamide mononucleotide).

  1. 01AnimalNot a test of NMN (nicotinamide mononucleotide) aloneAnimal study (in vivo)Mechanism

    In the HINT2 overexpression study, restoration of mitochondrial NAD levels depended on NMN.

    In plain wordsIn mice, HINT2 overexpression restored mitochondrial NAD levels through a process that depended on NMN.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseNMN-dependent mitochondrial NAD restoration
    Study

    mousen: not reported in source

    myocardial infarction-induced heart failure
    Outcome group
    Mitochondrial function · Cardiovascular

    Source sentences

    Summary
    HINT2 overexpression restored mitochondrial NAD levels; this was dependent on nicotinamide mononucleotide (NMN).
    1 context sentence
    Summary · context
    Neonatal mouse ventricle myocytes (NMVMs) and myocardial infarction-induced heart failure mice were used for in vitro or in vivo experiments.

    In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).

  2. 02LabNot a test of NMN (nicotinamide mononucleotide) aloneIn vitro (cell-free)Mechanism

    Biolayer interferometry suggested that HINT2 potentially binds and associates with NMN.

    In plain wordsIn lab tests, HINT2 potentially bound and associated with NMN.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Not applicableHINT2 association with NMN
    Study

    n: not reported in source

    biolayer interferometry
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    Using computer-simulated molecular docking analysis and biolayer interferometry, we observed that HINT2 potentially binds and associates with NMN.
    1 context sentence
    Summary · context
    Molecule binding kinetics assays were performed using biolayer interferometry.

    In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).

  3. 03Computer modelNot a test of NMN (nicotinamide mononucleotide) aloneIn silicoMechanism

    Molecular docking suggested that HINT2 potentially binds NMN.

    In plain wordsComputer analysis suggested that HINT2 could bind NMN.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Not applicablePredicted HINT2 binding to NMN
    Study

    n: not reported in source

    rigid body molecular docking
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    Using computer-simulated molecular docking analysis and biolayer interferometry, we observed that HINT2 potentially binds and associates with NMN.
    1 context sentence
    Summary · context
    Computer-simulated rigid body molecular docking was performed using AUTODOCK4.

    In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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