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Study · In vitro (cells) · 2020

3 results

Thymosin beta 4 attenuates PrP(106-126)-induced human brain endothelial cells dysfunction.

Song K, Han HJ, Kim S, Kwon J

European journal of pharmacology23 Dec 2019Cited by 9 (Europe PMC)

PMID31877278 (opens in a new tab)DOI10.1016/j.ejphar.2019.172891 (opens in a new tab)PepBankPUB-31877278
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In human cerebral endothelial cells, Tβ4 increased the expression of tight junction protein.

    In plain wordsIn cells, Tβ4 increased a protein that seals the gaps between brain blood vessel cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseTight junction protein expression
    Study

    humann: not reported in source

    hCMEC/D3 human cerebral endothelial cells
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We found that Tβ4 increased the expression of tight junction protein, but reduced the ratio of F-actin to G-actin.
    1 context sentence
    Summary · context
    Therefore, in this study, we investigated the effect of Tβ4 on prion-induced BBB dysfunction in hCMEC/D3 human cerebral endothelial cells.
  2. 02LabIn vitro (cells)Mechanism

    In human cerebral endothelial cells, Tβ4 reduced the ratio of F-actin to G-actin.

    In plain wordsIn cells, Tβ4 lowered the ratio of two forms of the protein actin.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseF-actin to G-actin ratio
    Study

    humann: not reported in source

    hCMEC/D3 human cerebral endothelial cells
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We found that Tβ4 increased the expression of tight junction protein, but reduced the ratio of F-actin to G-actin.
    1 context sentence
    Summary · context
    Therefore, in this study, we investigated the effect of Tβ4 on prion-induced BBB dysfunction in hCMEC/D3 human cerebral endothelial cells.
  3. 03LabIn vitro (cells)Efficacy outcome

    In human cerebral endothelial cells, Tβ4 significantly improved the vascular permeability dysfunction that PrP(106-126) induced.

    In plain wordsIn cells, Tβ4 improved the leaky barrier that a prion fragment caused.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Direction not reportedPrP(106-126)-induced vascular permeability dysfunction
    Study

    humann: not reported in source

    hCMEC/D3 human cerebral endothelial cells
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, we showed that Tβ4 significantly improved PrP (106-126)-induced vascular permeability dysfunction in hCMEC/D3 cells.
    1 context sentence
    Summary · context
    Therefore, in this study, we investigated the effect of Tβ4 on prion-induced BBB dysfunction in hCMEC/D3 human cerebral endothelial cells.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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