[Potential of peptidergic nootropic therapy in developmental dysphasia in children].

Zavadenko NN, Davydova LA, Suvorinova NY, Khondkaryan GS

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova1 Jan 2019

PMID31851172DOI10.17116/jnevro201911911147PepBankPUB-31851172

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

01HumanRandomized controlled trialEfficacy outcome
In children with developmental dysphasia, Cortexin treatment improved expressive language, attention to speech and impressive language scores.
In plain wordsIn children with developmental dysphasia, language scale scores improved after Cortexin treatment.
Peptide
Cortexin (cortical polypeptide complex)
Outcome
IncreaseLanguage scale scores
Study
n: not reported in source
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated · intramuscular · 10 daysAs given in this study (human).
Source sentences
Summary
After treatment with Cortexin, a significant improvement was achieved not only on the 'expressive language' scale but also on the 'attention to speech' and 'impressive language' scales.
3 context sentences(design, population, supporting numbers)
Summary · context
Fifty-four children with developmental dysphasia were randomized into two equal groups.
Summary · context
The cortexin group received the drug once daily intramuscularly during 10 days.
Summary · context
Before treatment and two months later, speech development was assessed by special scales and questionnaires for parents.
Report a problemFND-3185117201
02HumanRandomized controlled trialEfficacy outcome
In children with developmental dysphasia, active vocabulary increased 2.3 times after Cortexin treatment.
In plain wordsIn children with developmental dysphasia, active vocabulary increased 2.3 times after Cortexin treatment.
Peptide
Cortexin (cortical polypeptide complex)
Outcome
IncreaseActive vocabulary
Study
n: not reported in source
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated · intramuscular · 10 daysAs given in this study (human).
Measurements
Active vocabulary increase
2.3 times
after treatment
Source sentences
Summary
The volume of active vocabulary was increased by 2.3 times, the number of articulated phrases by 3.6 times.
3 context sentences(design, population, supporting numbers)
Summary · context
Fifty-four children with developmental dysphasia were randomized into two equal groups.
Summary · context
The cortexin group received the drug once daily intramuscularly during 10 days.
Summary · context
Before treatment and two months later, speech development was assessed by special scales and questionnaires for parents.
Report a problemFND-3185117202
03HumanRandomized controlled trialEfficacy outcome
In children with developmental dysphasia, the number of articulated phrases increased 3.6 times after Cortexin treatment.
In plain wordsIn children with developmental dysphasia, articulated phrases increased 3.6 times after Cortexin treatment.
Peptide
Cortexin (cortical polypeptide complex)
Outcome
IncreaseArticulated phrases
Study
n: not reported in source
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated · intramuscular · 10 daysAs given in this study (human).
Measurements
Articulated phrase increase
3.6 times
after treatment
Source sentences
Summary
The volume of active vocabulary was increased by 2.3 times, the number of articulated phrases by 3.6 times.
3 context sentences(design, population, supporting numbers)
Summary · context
Fifty-four children with developmental dysphasia were randomized into two equal groups.
Summary · context
The cortexin group received the drug once daily intramuscularly during 10 days.
Summary · context
Before treatment and two months later, speech development was assessed by special scales and questionnaires for parents.
Report a problemFND-3185117203
04HumanRandomized controlled trialEfficacy outcome
In children with developmental dysphasia, parents reported fewer somatic, motor, attention and emotional problems after Cortexin treatment.
In plain wordsIn children with developmental dysphasia, parents reported fewer behavioral and somatic problems after Cortexin treatment.
Peptide
Cortexin (cortical polypeptide complex)
Outcome
DecreaseParent-reported behavioral and somatic problems
Study
n: not reported in source
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated · intramuscular · 10 daysAs given in this study (human).
Source sentences
Summary
The evaluation of parents' questionnaires demonstrated the decrease of cerebrasthenic, psychosomatic problems, motor clumsiness, hyperactivity, attention deficit and problems with emotional control in children.
3 context sentences(design, population, supporting numbers)
Summary · context
Fifty-four children with developmental dysphasia were randomized into two equal groups.
Summary · context
The cortexin group received the drug once daily intramuscularly during 10 days.
Summary · context
Before treatment and two months later, speech development was assessed by special scales and questionnaires for parents.
Report a problemFND-3185117204
05HumanRandomized controlled trialEfficacy outcome
In children with developmental dysphasia, Cortexin therapy reduced difficulties in communication and social adaptation.
In plain wordsIn children with developmental dysphasia, communication and social adaptation difficulties decreased after Cortexin therapy.
Peptide
Cortexin (cortical polypeptide complex)
Outcome
DecreaseCommunication and social adaptation difficulties
Study
n: not reported in source
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated · intramuscular · 10 daysAs given in this study (human).
Source sentences
Summary
The therapy contributed to the reduction of difficulties in communication and social adaptation.
3 context sentences(design, population, supporting numbers)
Summary · context
Fifty-four children with developmental dysphasia were randomized into two equal groups.
Summary · context
The cortexin group received the drug once daily intramuscularly during 10 days.
Summary · context
Before treatment and two months later, speech development was assessed by special scales and questionnaires for parents.
Report a problemFND-3185117205

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:25 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

Keywords

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