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Study · Measured the body's own peptide · 2020

4 results

Murine maternal dietary restriction affects neural Humanin expression and cellular profile.

Baldauf C, Sondhi M, Shin BC, Ko YE, Ye X, Lee KW, Devaskar SU

Journal of neuroscience research15 Dec 2019Cited by 10 (Europe PMC)

PMID31840315 (opens in a new tab)PMCIDPMC7744116 (opens in a new tab)DOI10.1002/jnr.24568 (opens in a new tab)PepBankPUB-31840315
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Other

    In mice, the body's own mouse humanin expression was highest at embryonic day 19, diminished by postnatal day 15 and was nearly absent in adults.

    In plain wordsIn mice, the body's own humanin was highest before birth and nearly gone in adult mice.

    Peptide
    Humanin
    Outcome
    DecreaseMouse humanin expression across development
    Study

    micen: not reported in source

    Murine maternal calorie restriction (IUGR) model
    Outcome group
    Aging markers · Nervous system and cognition

    Source sentences

    Summary
    Ontogeny examination revealed highest mHN expression at E19, diminishing by postnatal day 15 (P15), and nearly absent in adult (3 months).
    1 context sentence
    Summary · context
    Our model employed maternal calorie restriction to 50% daily food intake from gestation day 10-19, producing IUGR offspring.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Other

    In mouse fetuses at embryonic day 19, males had higher mouse humanin expression than females.

    In plain wordsIn mouse fetuses, the body's own humanin was higher in males than in females.

    Peptide
    Humanin
    Outcome
    IncreaseMouse humanin expression by sex at E19
    Study

    micen: not reported in source

    Murine maternal calorie restriction (IUGR) model
    Comparator
    Female fetuses
    Outcome group
    Aging markers · Nervous system and cognition

    Source sentences

    Summary
    Subanalysis by sex at E19 yielded higher mHN expression among males during fetal life
    1 context sentence
    Summary · context
    Our model employed maternal calorie restriction to 50% daily food intake from gestation day 10-19, producing IUGR offspring.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Other

    In mice after birth, mouse humanin expression did not differ significantly between sexes.

    In plain wordsIn mice after birth, the body's own humanin did not differ between males and females.

    Peptide
    Humanin
    Outcome
    No significant changeMouse humanin expression by sex after birth
    Study

    micen: not reported in source

    Murine maternal calorie restriction (IUGR) model
    Comparator
    Female mice
    Outcome group
    Aging markers · Nervous system and cognition

    Source sentences

    Summary
    without significant difference between sexes postnatally.
    1 context sentence
    Summary · context
    Our model employed maternal calorie restriction to 50% daily food intake from gestation day 10-19, producing IUGR offspring.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  4. 04AnimalEndogenous levelAnimal study (in vivo)Other

    In mouse fetuses at embryonic day 19, female IUGR fetuses had a greater increase in cortical mouse humanin over their controls than male IUGR fetuses.

    In plain wordsIn mouse fetuses with restricted growth, the body's own humanin rose more in females than in males.

    Peptide
    Humanin
    Outcome
    IncreaseCortical mouse humanin in IUGR fetuses
    Study

    micen: not reported in source

    Murine maternal calorie restriction (IUGR) model
    Comparator
    Male IUGR fetuses over their controls
    Outcome group
    Aging markers · Nervous system and cognition

    Source sentences

    Summary
    Furthermore, female IUGR mice at E19 had a greater increase in cortical mHN versus the male fetus over their respective controls.
    1 context sentence
    Summary · context
    Our model employed maternal calorie restriction to 50% daily food intake from gestation day 10-19, producing IUGR offspring.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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