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Study · Animal study (in vivo) · rat · 2020

4 results

Phasic dopamine responses to a food-predictive cue are suppressed by the glucagon-like peptide-1 receptor agonist Exendin-4.

Konanur VR, Hsu TM, Kanoski SE, Hayes MR, Roitman MF

Physiology & behavior9 Dec 2019Cited by 55 (Europe PMC)

PMID31821815 (opens in a new tab)PMCIDPMC8112128 (opens in a new tab)DOI10.1016/j.physbeh.2019.112771 (opens in a new tab)PepBankPUB-31821815
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male and female rats, ventricular Exendin‑4 dose-dependently suppressed sucrose-directed behavior compared with zero dose.

    In plain wordsIn rats, Exendin‑4 in the brain dose-dependently reduced sucrose-directed behavior compared with zero dose.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseSucrose-directed behavior
    Study

    ratn: not reported in source

    Male and female TH:Cre+ rats trained with a sucrose-predictive audio cue
    Comparator
    0 μg Exendin-4
    Outcome group
    Appetite and food intake · Nervous system and cognition
    Studied dose
    0.05 and 0.1 μg · lateral ventricleAs given in this study (rat).

    Source sentences

    Summary
    Administration of Exendin-4 (Ex4; 0, 0.05, 0.1 μg) to the lateral ventricle both dose-dependently suppressed sucrose-directed behaviors and the magnitude of cue-evoked dopamine activity.
    1 context sentence
    Summary · context
    Here, in vivo fiber photometry was used to capture real-time signaling dynamics selectively from dopamine neurons in the ventral tegmental area of male and female transgenic (tyrosine hydroxylase-Cre; TH:Cre+) rats trained to associate an audio cue with the brief availability of a sucrose solution.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In male and female rats, ventricular Exendin‑4 dose-dependently suppressed cue-evoked dopamine activity compared with zero dose.

    In plain wordsIn rats, Exendin‑4 in the brain dose-dependently reduced cue-evoked dopamine activity compared with zero dose.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseCue-evoked dopamine activity
    Study

    ratn: not reported in source

    Male and female TH:Cre+ rats trained with a sucrose-predictive audio cue
    Comparator
    0 μg Exendin-4
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    0.05 and 0.1 μg · lateral ventricleAs given in this study (rat).

    Source sentences

    Summary
    Administration of Exendin-4 (Ex4; 0, 0.05, 0.1 μg) to the lateral ventricle both dose-dependently suppressed sucrose-directed behaviors and the magnitude of cue-evoked dopamine activity.
    1 context sentence
    Summary · context
    Here, in vivo fiber photometry was used to capture real-time signaling dynamics selectively from dopamine neurons in the ventral tegmental area of male and female transgenic (tyrosine hydroxylase-Cre; TH:Cre+) rats trained to associate an audio cue with the brief availability of a sucrose solution.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats, dopamine responses were lower in females than males, but sex did not significantly interact with Exendin‑4 treatment.

    In plain wordsIn rats, females had lower dopamine responses than males, but sex did not significantly change the Exendin‑4 effect.

    Peptide
    Exenatide (exendin-4)
    Outcome
    No significant changeSex interaction with Exendin-4 on dopamine response
    Study

    ratn: not reported in source

    Male and female TH:Cre+ rats trained with a sucrose-predictive audio cue
    Comparator
    Female versus male rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    0.05 and 0.1 μg · lateral ventricleAs given in this study (rat).

    Source sentences

    Summary
    While female rats exhibited overall reduced dopamine responses to the sucrose-paired cue relative to males, there was no significant interaction with Ex4.
    1 context sentence
    Summary · context
    Here, in vivo fiber photometry was used to capture real-time signaling dynamics selectively from dopamine neurons in the ventral tegmental area of male and female transgenic (tyrosine hydroxylase-Cre; TH:Cre+) rats trained to associate an audio cue with the brief availability of a sucrose solution.

Studies that did not test the peptide alone1

In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Exenatide (exendin-4).

  1. 04AnimalNot a test of Exenatide (exendin-4) aloneAnimal study (in vivo)Mechanism

    In rats tested with Exendin‑4, cue-evoked dopamine amplitude correlated significantly with subsequent sucrose-directed behavior.

    In plain wordsIn rats tested with Exendin‑4, cue-evoked dopamine activity was linked to subsequent sucrose-directed behavior.

    Peptide
    Exenatide (exendin-4)
    Outcome
    Direction not reportedDopamine and subsequent sucrose behavior correlation
    Study

    ratn: not reported in source

    Male and female TH:Cre+ rats trained with a sucrose-predictive audio cue
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    Moreover, the amplitude of cue evoked dopamine activity was significantly correlated with subsequent sucrose-directed behaviors.
    1 context sentence
    Summary · context
    Here, in vivo fiber photometry was used to capture real-time signaling dynamics selectively from dopamine neurons in the ventral tegmental area of male and female transgenic (tyrosine hydroxylase-Cre; TH:Cre+) rats trained to associate an audio cue with the brief availability of a sucrose solution.

    In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Exenatide (exendin-4).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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