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Study · Animal study (in vivo) · mouse · 2020

11 results

Nicotinamide mononucleotide ameliorates the depression-like behaviors and is associated with attenuating the disruption of mitochondrial bioenergetics in depressed mice.

Xie X, Yu C, Zhou J, Xiao Q, Shen Q, Xiong Z, Li Z, Fu Z

Journal of affective disorders2 Dec 2019Cited by 55 (Europe PMC)

PMID31818774 (opens in a new tab)DOI10.1016/j.jad.2019.11.147 (opens in a new tab)PepBankPUB-31818774
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In corticosterone-treated mice, NMN alleviated depression-like behavior.

    In plain wordsIn mice treated with corticosterone, NMN reduced depression-like behavior.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseDepression-like behavior
    Study

    mousen: not reported in source

    corticosterone-induced depression
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    300 mg/kg · oral gavage · 2 weeksAs given in this study (mouse).

    Source sentences

    Summary
    NMN administration alleviated depression-like behavior and the liver weight to body weight ratio in a mouse model of CORT-induced depression.
    1 context sentence
    Summary · context
    Mice were subcutaneously injected with corticosterone (CORT; 20 mg/kg) each day for 6 weeks, while another group was given an additional dose of NMN (300 mg/kg) by oral gavage in the last 2 weeks.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In corticosterone-treated mice, NMN alleviated the liver weight to body weight ratio.

    In plain wordsIn mice treated with corticosterone, NMN reduced the liver weight to body weight ratio.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseLiver weight to body weight ratio
    Study

    mousen: not reported in source

    corticosterone-induced depression
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    300 mg/kg · oral gavage · 2 weeksAs given in this study (mouse).

    Source sentences

    Summary
    NMN administration alleviated depression-like behavior and the liver weight to body weight ratio in a mouse model of CORT-induced depression.
    1 context sentence
    Summary · context
    Mice were subcutaneously injected with corticosterone (CORT; 20 mg/kg) each day for 6 weeks, while another group was given an additional dose of NMN (300 mg/kg) by oral gavage in the last 2 weeks.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In depressed mice, NMN reduced mRNA expression of genes involved in fatty acid synthesis.

    In plain wordsIn depressed mice, NMN reduced expression of genes involved in fatty acid synthesis.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseFatty acid synthesis gene expression
    Study

    mousen: not reported in source

    corticosterone-induced depression
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    300 mg/kg · oral gavage · 2 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Transcriptome and metabolome analyses revealed that in depressed mice, NMN reduced the mRNA expression of genes involved in fatty acid synthesis, stimulation of β-oxidation and glycolysis, and increased production of acetyl-coenzyme A for the tricarboxylic acid cycle.
    1 context sentence
    Summary · context
    Mice were subcutaneously injected with corticosterone (CORT; 20 mg/kg) each day for 6 weeks, while another group was given an additional dose of NMN (300 mg/kg) by oral gavage in the last 2 weeks.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In depressed mice, NMN reduced mRNA expression of genes involved in stimulation of beta-oxidation.

    In plain wordsIn depressed mice, NMN reduced expression of genes involved in stimulation of beta-oxidation.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseBeta-oxidation-related gene expression
    Study

    mousen: not reported in source

    corticosterone-induced depression
    Outcome group
    Mitochondrial function · Metabolic and weight
    Studied dose
    300 mg/kg · oral gavage · 2 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Transcriptome and metabolome analyses revealed that in depressed mice, NMN reduced the mRNA expression of genes involved in fatty acid synthesis, stimulation of β-oxidation and glycolysis, and increased production of acetyl-coenzyme A for the tricarboxylic acid cycle.
    1 context sentence
    Summary · context
    Mice were subcutaneously injected with corticosterone (CORT; 20 mg/kg) each day for 6 weeks, while another group was given an additional dose of NMN (300 mg/kg) by oral gavage in the last 2 weeks.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In depressed mice, NMN reduced mRNA expression of genes involved in glycolysis.

    In plain wordsIn depressed mice, NMN reduced expression of genes involved in glycolysis.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseGlycolysis-related gene expression
    Study

    mousen: not reported in source

    corticosterone-induced depression
    Outcome group
    Mitochondrial function · Metabolic and weight
    Studied dose
    300 mg/kg · oral gavage · 2 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Transcriptome and metabolome analyses revealed that in depressed mice, NMN reduced the mRNA expression of genes involved in fatty acid synthesis, stimulation of β-oxidation and glycolysis, and increased production of acetyl-coenzyme A for the tricarboxylic acid cycle.
    1 context sentence
    Summary · context
    Mice were subcutaneously injected with corticosterone (CORT; 20 mg/kg) each day for 6 weeks, while another group was given an additional dose of NMN (300 mg/kg) by oral gavage in the last 2 weeks.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In depressed mice, NMN increased acetyl-coenzyme A production for the tricarboxylic acid cycle.

    In plain wordsIn depressed mice, NMN increased acetyl-coenzyme A production for the tricarboxylic acid cycle.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseAcetyl-coenzyme A production
    Study

    mousen: not reported in source

    corticosterone-induced depression
    Outcome group
    Mitochondrial function · Metabolic and weight
    Studied dose
    300 mg/kg · oral gavage · 2 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Transcriptome and metabolome analyses revealed that in depressed mice, NMN reduced the mRNA expression of genes involved in fatty acid synthesis, stimulation of β-oxidation and glycolysis, and increased production of acetyl-coenzyme A for the tricarboxylic acid cycle.
    1 context sentence
    Summary · context
    Mice were subcutaneously injected with corticosterone (CORT; 20 mg/kg) each day for 6 weeks, while another group was given an additional dose of NMN (300 mg/kg) by oral gavage in the last 2 weeks.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In corticosterone-treated mice, NMN increased NAD levels in the hippocampus and liver.

    In plain wordsIn mice treated with corticosterone, NMN increased NAD levels in the hippocampus and liver.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseNAD levels
    Study

    mousen: not reported in source

    corticosterone-induced depression
    Outcome group
    Mitochondrial function · Whole body
    Studied dose
    300 mg/kg · oral gavage · 2 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Importantly, NMN supplementation increased NAD+ levels to enhance sirtuin (SIRT)3 activity, thereby improving mitochondrial energy metabolism in the hippocampus and liver of CORT-treated mice.
    1 context sentence
    Summary · context
    Mice were subcutaneously injected with corticosterone (CORT; 20 mg/kg) each day for 6 weeks, while another group was given an additional dose of NMN (300 mg/kg) by oral gavage in the last 2 weeks.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In corticosterone-treated mice, NMN enhanced SIRT3 activity in the hippocampus and liver.

    In plain wordsIn mice treated with corticosterone, NMN increased SIRT3 activity in the hippocampus and liver.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseSIRT3 activity
    Study

    mousen: not reported in source

    corticosterone-induced depression
    Outcome group
    Receptor activity and mechanism · Whole body
    Studied dose
    300 mg/kg · oral gavage · 2 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Importantly, NMN supplementation increased NAD+ levels to enhance sirtuin (SIRT)3 activity, thereby improving mitochondrial energy metabolism in the hippocampus and liver of CORT-treated mice.
    1 context sentence
    Summary · context
    Mice were subcutaneously injected with corticosterone (CORT; 20 mg/kg) each day for 6 weeks, while another group was given an additional dose of NMN (300 mg/kg) by oral gavage in the last 2 weeks.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In corticosterone-treated mice, NMN improved mitochondrial energy metabolism in the hippocampus and liver.

    In plain wordsIn mice treated with corticosterone, NMN improved mitochondrial energy metabolism in the hippocampus and liver.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseMitochondrial energy metabolism
    Study

    mousen: not reported in source

    corticosterone-induced depression
    Outcome group
    Mitochondrial function · Whole body
    Studied dose
    300 mg/kg · oral gavage · 2 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Importantly, NMN supplementation increased NAD+ levels to enhance sirtuin (SIRT)3 activity, thereby improving mitochondrial energy metabolism in the hippocampus and liver of CORT-treated mice.
    1 context sentence
    Summary · context
    Mice were subcutaneously injected with corticosterone (CORT; 20 mg/kg) each day for 6 weeks, while another group was given an additional dose of NMN (300 mg/kg) by oral gavage in the last 2 weeks.

Studies that did not test the peptide alone2

In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking NMN (nicotinamide mononucleotide).

  1. 10LabNot a test of NMN (nicotinamide mononucleotide) aloneIn vitro (cells)Mechanism

    In primary mouse astrocytes, Sirt3 knockdown reversed NMN's effect by inhibiting energy production.

    In plain wordsIn cells from mice, Sirt3 knockdown reversed NMN's effect by reducing energy production.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseEnergy production after Sirt3 knockdown
    Study

    mousen: not reported in source

    primary mouse astrocytes
    Outcome group
    Mitochondrial function · Nervous system and cognition

    Source sentences

    Summary
    Sirt3knockdown in primary mouse astrocytes reversed the effect of NMN by inhibiting energy production, although it did not affect NAD+ synthesis

    In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).

  2. 11LabNot a test of NMN (nicotinamide mononucleotide) aloneIn vitro (cells)Mechanism

    In primary mouse astrocytes, Sirt3 knockdown did not affect NAD synthesis despite reversing NMN's effect on energy production.

    In plain wordsIn cells from mice, Sirt3 knockdown did not affect NAD synthesis.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    No significant changeNAD synthesis after Sirt3 knockdown
    Study

    mousen: not reported in source

    primary mouse astrocytes
    Outcome group
    Mitochondrial function · Nervous system and cognition

    Source sentences

    Summary
    Sirt3knockdown in primary mouse astrocytes reversed the effect of NMN by inhibiting energy production, although it did not affect NAD+ synthesis

    In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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