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Study · Animal study (in vivo) · rat · 2020

9 results

SS31 attenuates oxidative stress and neuronal apoptosis in early brain injury following subarachnoid hemorrhage possibly by the mitochondrial pathway.

Shen R, Zhou J, Li G, Chen W, Zhong W, Chen Z

Neuroscience letters27 Nov 2019Cited by 23 (Europe PMC)

PMID31785308 (opens in a new tab)DOI10.1016/j.neulet.2019.134654 (opens in a new tab)PepBankPUB-31785308
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with subarachnoid hemorrhage, SS31 significantly reduced MDA levels in the temporal cortex compared with vehicle.

    In plain wordsIn rats with brain bleeding, SS31 lowered a marker of oxidative damage in the brain compared with vehicle.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMalondialdehyde (MDA) level in temporal cortex
    Study

    ratn: not reported in source

    SAH prechiasmatic cistern model
    Comparator
    SAH + vehicle
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    treatment with SS31 significantly reduced MDA levels
    2 context sentences
    Summary · context
    Sprague-Dawley rats were randomly divided into four groups: Sham, SAH, SAH + vehicle, and SAH + SS31 groups.
    Summary · context
    The SAH-induced prechiasmatic cistern rat model was established in this study.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with subarachnoid hemorrhage, SS31 restored GPx activity in the temporal cortex compared with vehicle.

    In plain wordsIn rats with brain bleeding, SS31 restored an antioxidant enzyme's activity in the brain compared with vehicle.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseGlutathione peroxidase (GPx) activity in temporal cortex
    Study

    ratn: not reported in source

    SAH prechiasmatic cistern model
    Comparator
    SAH + vehicle
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    restored the activities of GPx and SOD in the temporal cortex following SAH when compared with the vehicle-treated group.
    2 context sentences
    Summary · context
    Sprague-Dawley rats were randomly divided into four groups: Sham, SAH, SAH + vehicle, and SAH + SS31 groups.
    Summary · context
    The SAH-induced prechiasmatic cistern rat model was established in this study.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with subarachnoid hemorrhage, SS31 restored SOD activity in the temporal cortex compared with vehicle.

    In plain wordsIn rats with brain bleeding, SS31 restored another antioxidant enzyme's activity in the brain compared with vehicle.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseSuperoxide dismutase (SOD) activity in temporal cortex
    Study

    ratn: not reported in source

    SAH prechiasmatic cistern model
    Comparator
    SAH + vehicle
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    restored the activities of GPx and SOD in the temporal cortex following SAH when compared with the vehicle-treated group.
    2 context sentences
    Summary · context
    Sprague-Dawley rats were randomly divided into four groups: Sham, SAH, SAH + vehicle, and SAH + SS31 groups.
    Summary · context
    The SAH-induced prechiasmatic cistern rat model was established in this study.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with subarachnoid hemorrhage, SS31 increased the level of mitochondrial cytochrome C.

    In plain wordsIn rats with brain bleeding, SS31 raised the amount of cytochrome C kept inside mitochondria.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMitochondrial cytochrome C level
    Study

    ratn: not reported in source

    SAH prechiasmatic cistern model
    Comparator
    SAH + vehicle
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    the levels of mitochondrial Cyt C and Bax respectively increased and decreased by SS31 treatment.
    2 context sentences
    Summary · context
    Sprague-Dawley rats were randomly divided into four groups: Sham, SAH, SAH + vehicle, and SAH + SS31 groups.
    Summary · context
    The SAH-induced prechiasmatic cistern rat model was established in this study.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with subarachnoid hemorrhage, SS31 decreased the level of the pro-apoptotic protein Bax.

    In plain wordsIn rats with brain bleeding, SS31 lowered the level of a protein that promotes cell death.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseBax level
    Study

    ratn: not reported in source

    SAH prechiasmatic cistern model
    Comparator
    SAH + vehicle
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    the levels of mitochondrial Cyt C and Bax respectively increased and decreased by SS31 treatment.
    2 context sentences
    Summary · context
    Sprague-Dawley rats were randomly divided into four groups: Sham, SAH, SAH + vehicle, and SAH + SS31 groups.
    Summary · context
    The SAH-induced prechiasmatic cistern rat model was established in this study.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats with subarachnoid hemorrhage, SS31 ameliorated brain edema at 24 h.

    In plain wordsIn rats with brain bleeding, SS31 reduced brain swelling at 24 hours.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseBrain edema at 24 h after SAH
    Study

    ratn: not reported in source

    SAH prechiasmatic cistern model
    Comparator
    SAH + vehicle
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, SS31 treatment ameliorated brain edema and Evans blue dye extravasation, improved neurological deficits, and decreased neuronal apoptosis at 24 h after SAH.
    2 context sentences
    Summary · context
    Sprague-Dawley rats were randomly divided into four groups: Sham, SAH, SAH + vehicle, and SAH + SS31 groups.
    Summary · context
    The SAH-induced prechiasmatic cistern rat model was established in this study.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats with subarachnoid hemorrhage, SS31 ameliorated Evans blue dye extravasation (blood-brain barrier leakage) at 24 h.

    In plain wordsIn rats with brain bleeding, SS31 reduced leakage across the blood-brain barrier at 24 hours.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseEvans blue dye extravasation at 24 h after SAH
    Study

    ratn: not reported in source

    SAH prechiasmatic cistern model
    Comparator
    SAH + vehicle
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, SS31 treatment ameliorated brain edema and Evans blue dye extravasation, improved neurological deficits, and decreased neuronal apoptosis at 24 h after SAH.
    2 context sentences
    Summary · context
    Sprague-Dawley rats were randomly divided into four groups: Sham, SAH, SAH + vehicle, and SAH + SS31 groups.
    Summary · context
    The SAH-induced prechiasmatic cistern rat model was established in this study.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rats with subarachnoid hemorrhage, SS31 improved neurological deficits at 24 h.

    In plain wordsIn rats with brain bleeding, SS31 improved nerve-function deficits at 24 hours.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseNeurological deficits at 24 h after SAH
    Study

    ratn: not reported in source

    SAH prechiasmatic cistern model
    Comparator
    SAH + vehicle
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, SS31 treatment ameliorated brain edema and Evans blue dye extravasation, improved neurological deficits, and decreased neuronal apoptosis at 24 h after SAH.
    2 context sentences
    Summary · context
    Sprague-Dawley rats were randomly divided into four groups: Sham, SAH, SAH + vehicle, and SAH + SS31 groups.
    Summary · context
    The SAH-induced prechiasmatic cistern rat model was established in this study.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In rats with subarachnoid hemorrhage, SS31 decreased neuronal apoptosis at 24 h.

    In plain wordsIn rats with brain bleeding, SS31 reduced nerve cell death at 24 hours.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseNeuronal apoptosis at 24 h after SAH
    Study

    ratn: not reported in source

    SAH prechiasmatic cistern model
    Comparator
    SAH + vehicle
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, SS31 treatment ameliorated brain edema and Evans blue dye extravasation, improved neurological deficits, and decreased neuronal apoptosis at 24 h after SAH.
    2 context sentences
    Summary · context
    Sprague-Dawley rats were randomly divided into four groups: Sham, SAH, SAH + vehicle, and SAH + SS31 groups.
    Summary · context
    The SAH-induced prechiasmatic cistern rat model was established in this study.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

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