In a meta-analysis of randomized trials of liraglutide, liraglutide significantly reduced body weight compared with placebo.
In plain wordsIn a pooled analysis of trials, liraglutide reduced body weight more than placebo.
- Peptide
- Liraglutide
- Outcome
- DecreaseBody weight reduction
- Study
n = 4,978
- Comparator
- Placebo
- Outcome group
- Body weight · Metabolic and weight
- Studied dose
- Dose not stated · at least 1 yearAs given in this study (human).
Measurements
- Body weight difference vs placebo
- −5.25 Kg
- liraglutide, 95% CI -6.17 to -4.32
Source sentences
liraglutide (N = 4978; ∆ -5.25 Kg; 95% CI, -6.17 to -4.32), compared to placebo (all p < 0.00001)
1 context sentence(design, population, supporting numbers)
We systematically searched the database of PubMed, Embase, The Cochrane Library and The ClinicalTrials.gov up to 30 September 2019 and retrieved all the randomized controlled trials (RCTs) that were conducted with these five drugs for ≥1 year and explicitly reported their efficacy versus placebo.