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Study · Animal study (in vivo) · mouse · 2020

6 results

Mitochondrial oxidative stress induces leaky ryanodine receptor during mechanical ventilation.

Dridi H, Yehya M, Barsotti R, Reiken S, Angebault C, Jung B, Jaber S, Marks AR, Lacampagne A, Matecki S

Free radical biology & medicine19 Nov 2019Cited by 40 (Europe PMC)

PMID31756525 (opens in a new tab)DOI10.1016/j.freeradbiomed.2019.11.019 (opens in a new tab)PepBankPUB-31756525
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In mice ventilated for 6 h, SS31 treatment prevented mitochondrial ROS production.

    In plain wordsIn ventilated mice, SS31 prevented the rise in mitochondrial reactive oxygen species.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMitochondrial ROS production during 6 h ventilation
    Study

    mousen: not reported in source

    Mechanically ventilated mouse diaphragm (6 h and 12 h)
    Comparator
    Mechanical ventilation without SS31
    Outcome group
    Mitochondrial function · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Preventing mROS production by SS31 treatment does not affect the TGFβ1 and STAT3 activation, which suggests that mitochondrial oxidative stress is a downstream pathway to TGFβ1 and STAT3, early involved in VIDD.
    2 context sentences
    Summary · context
    6 h of mechanical ventilation (MV) resulted in increased mitochondrial ROS production, reduction of mitochondrial aconitase activity, increased oxidation, S-nitrosylation, S-glutathionylation and Ser-2844 phosphorylation of RyR1, depletion of stabilizing subunit calstabin1 from RyR1, increased SR Ca2+ leak.
    Summary · context
    In mice diaphragms mechanically ventilated for short (6 h) and long (12 h) period
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mice ventilated for 6 h, SS31 treatment did not affect TGFβ1 and STAT3 activation.

    In plain wordsIn ventilated mice, SS31 did not change TGFβ1 and STAT3 activation.

    Peptide
    Elamipretide (SS-31)
    Outcome
    No significant changeTGFβ1 and STAT3 activation
    Study

    mousen: not reported in source

    Mechanically ventilated mouse diaphragm (6 h and 12 h)
    Comparator
    Mechanical ventilation without SS31
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Preventing mROS production by SS31 treatment does not affect the TGFβ1 and STAT3 activation, which suggests that mitochondrial oxidative stress is a downstream pathway to TGFβ1 and STAT3, early involved in VIDD.
    1 context sentence
    Summary · context
    In mice diaphragms mechanically ventilated for short (6 h) and long (12 h) period
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice ventilated for 6 h, SS‑31 rescued the RyR1 remodeling and sarcoplasmic reticulum Ca2+ leak.

    In plain wordsIn ventilated mice, SS‑31 reversed changes to a muscle calcium channel and calcium leak.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseRyR1 remodeling and SR Ca2+ leak at 6 h
    Study

    mousen: not reported in source

    Mechanically ventilated mouse diaphragm (6 h and 12 h)
    Comparator
    Mechanical ventilation without SS31
    Outcome group
    Mitochondrial function · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This is further supported by the fact that SS-31 rescue all the other described cellular events and diaphragm contractile dysfunction induced by MV, while SS20, an analog of SS31 lacking antioxidant properties, failed to prevent these cellular events and the contractile dysfunction.
    2 context sentences
    Summary · context
    6 h of mechanical ventilation (MV) resulted in increased mitochondrial ROS production, reduction of mitochondrial aconitase activity, increased oxidation, S-nitrosylation, S-glutathionylation and Ser-2844 phosphorylation of RyR1, depletion of stabilizing subunit calstabin1 from RyR1, increased SR Ca2+ leak.
    Summary · context
    In mice diaphragms mechanically ventilated for short (6 h) and long (12 h) period
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice ventilated for 6 h, SS‑31 rescued the diaphragm contractile dysfunction.

    In plain wordsIn ventilated mice, SS‑31 rescued weakened diaphragm contraction.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseDiaphragm contractile dysfunction at 6 h
    Study

    mousen: not reported in source

    Mechanically ventilated mouse diaphragm (6 h and 12 h)
    Comparator
    Mechanical ventilation without SS31
    Outcome group
    Exercise and physical function · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This is further supported by the fact that SS-31 rescue all the other described cellular events and diaphragm contractile dysfunction induced by MV, while SS20, an analog of SS31 lacking antioxidant properties, failed to prevent these cellular events and the contractile dysfunction.
    1 context sentence
    Summary · context
    In mice diaphragms mechanically ventilated for short (6 h) and long (12 h) period
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice ventilated for 12 h, SS31 treatment prevented calpain1 activity.

    In plain wordsIn ventilated mice, SS31 prevented activity of an enzyme that breaks down muscle protein.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseCalpain1 activity after 12 h ventilation
    Study

    mousen: not reported in source

    Mechanically ventilated mouse diaphragm (6 h and 12 h)
    Comparator
    Mechanical ventilation without SS31
    Outcome group
    Muscle injury and repair · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, SS31 treatment prevented calpain1 activity and diaphragm atrophy observed after 12 h of MV.
    1 context sentence
    Summary · context
    In mice diaphragms mechanically ventilated for short (6 h) and long (12 h) period
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In mice ventilated for 12 h, SS31 treatment prevented diaphragm atrophy.

    In plain wordsIn ventilated mice, SS31 prevented shrinking of the diaphragm muscle.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseDiaphragm atrophy after 12 h ventilation
    Study

    mousen: not reported in source

    Mechanically ventilated mouse diaphragm (6 h and 12 h)
    Comparator
    Mechanical ventilation without SS31
    Outcome group
    Muscle injury and repair · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, SS31 treatment prevented calpain1 activity and diaphragm atrophy observed after 12 h of MV.
    1 context sentence
    Summary · context
    In mice diaphragms mechanically ventilated for short (6 h) and long (12 h) period

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

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