Electrospun thymosin Beta-4 loaded PLGA/PLA nanofiber/ microfiber hybrid yarns for tendon tissue engineering application.

Wu S, Zhou R, Zhou F, Streubel PN, Chen S, Duan B

Materials science & engineering. C, Materials for biological applications12 Oct 2019Cited by 63 (Europe PMC)

PMID31753373PMCIDPMC7061461DOI10.1016/j.msec.2019.110268PepBankPUB-31753373

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

01LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Efficacy outcome
In human adipose derived stem cells, Tβ4-loaded hybrid yarn showed an additive effect on promoting cell migration.
In plain wordsIn human fat stem cells, a fiber yarn loaded with Tβ4 added to the increase in cell movement.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseHADMSC migration
Study
humann: not reported in source
human adipose derived mesenchymal stem cells (HADMSC)
Outcome group
Tendon and ligament healing · Musculoskeletal
Source sentences
Summary
and showed an additive effect on promoting HADMSC migration, proliferation, and tenogenic differentiation.
1 context sentence(design, population, supporting numbers)
Summary · context
Herein, we designed a modified electrospinning device to coat poly(lactic-co-glycolic acid) PLGA nanofibers onto polylactic acid (PLA) MY to generate PLGA/PLA hybrid yarns (HY), which had a well-aligned nanofibrous structure, resembling the ultrastructure of native tendon tissues and showed enhanced…
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-3175337302
02LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Efficacy outcome
In human adipose derived stem cells, Tβ4-loaded hybrid yarn showed an additive effect on promoting cell proliferation.
In plain wordsIn human fat stem cells, a fiber yarn loaded with Tβ4 added to the increase in cell growth.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseHADMSC proliferation
Study
humann: not reported in source
human adipose derived mesenchymal stem cells (HADMSC)
Outcome group
Tendon and ligament healing · Musculoskeletal
Source sentences
Summary
and showed an additive effect on promoting HADMSC migration, proliferation, and tenogenic differentiation.
1 context sentence(design, population, supporting numbers)
Summary · context
Herein, we designed a modified electrospinning device to coat poly(lactic-co-glycolic acid) PLGA nanofibers onto polylactic acid (PLA) MY to generate PLGA/PLA hybrid yarns (HY), which had a well-aligned nanofibrous structure, resembling the ultrastructure of native tendon tissues and showed enhanced…
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-3175337303
03LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Efficacy outcome
In human adipose derived stem cells, Tβ4-loaded hybrid yarn showed an additive effect on promoting tenogenic differentiation.
In plain wordsIn human fat stem cells, a fiber yarn loaded with Tβ4 added to the increase in turning into tendon-type cells.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseHADMSC tenogenic differentiation
Study
humann: not reported in source
human adipose derived mesenchymal stem cells (HADMSC)
Outcome group
Tendon and ligament healing · Musculoskeletal
Source sentences
Summary
and showed an additive effect on promoting HADMSC migration, proliferation, and tenogenic differentiation.
1 context sentence(design, population, supporting numbers)
Summary · context
Herein, we designed a modified electrospinning device to coat poly(lactic-co-glycolic acid) PLGA nanofibers onto polylactic acid (PLA) MY to generate PLGA/PLA hybrid yarns (HY), which had a well-aligned nanofibrous structure, resembling the ultrastructure of native tendon tissues and showed enhanced…
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-3175337304
04LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cell-free)Other
Tβ4 loaded PLGA/PLA hybrid yarns released the drug in a sustained manner for 28 days.
In plain wordsIn lab tests, yarns loaded with Tβ4 released it slowly for 28 days.
Peptide
Thymosin beta-4 (human)
Outcome
Not applicableTβ4 release from hybrid yarn
Study
n: not reported in source
Tβ4-loaded PLGA/PLA hybrid yarn
Outcome group
Pharmacokinetics · Pharmacology
Measurements
release duration
28 days
Tβ4-loaded PLGA/PLA HY
Source sentences
Summary
thymosin beta-4 (Tβ4) loaded PLGA/PLA HY presented a sustained drug release manner for 28 days
1 context sentence(design, population, supporting numbers)
Summary · context
Herein, we designed a modified electrospinning device to coat poly(lactic-co-glycolic acid) PLGA nanofibers onto polylactic acid (PLA) MY to generate PLGA/PLA hybrid yarns (HY), which had a well-aligned nanofibrous structure, resembling the ultrastructure of native tendon tissues and showed enhanced…
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-3175337301

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.