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Study · Not a test of the peptide alone · 2019

4 results

Genetic variants in humanin nuclear isoform gene regions show no association with coronary artery disease.

Eltermaa M, Jakobson M, Utt M, Kõks S, Mägi R, Starkopf J

BMC research notes21 Nov 2019Cited by 9 (Europe PMC)

PMID31753007 (opens in a new tab)PMCIDPMC6873426 (opens in a new tab)DOI10.1186/s13104-019-4807-x (opens in a new tab)PepBankPUB-31753007
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Summary

ObjectiveCoronary artery disease contributes to noncommunicable disease deaths worldwide. In order to make preventive methods more accurate, we need to know more about the development and progress of this pathology, including the genetic aspects. Humanin is a small peptide known for its cytoprotective and anti-apoptotic properties. Our study looked for genomic associations between humanin-like nuclear isoform genes and coronary artery disease using CARDIoGRAMplusC4D Consortium data.ResultsLookup from meta-analysis datasets gave single nucleotide polymorphisms in all 13 humanin-like nuclear isoform genes with the lowest P value for rs6151662 from the MTRNR2L2 gene including the 50 kb flanking region in both directions (P-value = 0.0037). Within the gene region alone the top variant was rs78083998 from the MTRNR2L13 region (meta-analysis P-value = 0.042). None of the found associations were statistically significant after correction for multiple testing. Lookup for expression trait loci in these gene regions gave no statistically significant variants.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 01HumanNot a test of Humanin aloneObservational studyOther

    In CARDIoGRAMplusC4D meta-analysis data, none of the associations between humanin-like nuclear isoform gene variants and coronary artery disease was significant after correction for multiple testing.

    In plain wordsIn a large genetic data set, no humanin-like gene variant was linked to coronary artery disease after correction for multiple testing.

    Peptide
    Humanin
    Outcome
    No significant changeAssociation of humanin-like gene variants with coronary artery disease after multiple-testing correction
    Study

    n: not reported in source

    Outcome group
    Genetic association · Cardiovascular

    Source sentences

    Summary
    None of the found associations were statistically significant after correction for multiple testing.
    1 context sentence
    Summary · context
    Our study looked for genomic associations between humanin-like nuclear isoform genes and coronary artery disease using CARDIoGRAMplusC4D Consortium data.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  2. 02HumanNot a test of Humanin aloneObservational studyOther

    The lowest P value, for rs6151662 in MTRNR2L2 including 50 kb flanking regions, was 0.0037.

    In plain wordsThe strongest single link was for rs6151662 in the MTRNR2L2 gene region, but it did not hold after correction.

    Peptide
    Humanin
    Outcome
    Not applicableLowest-P variant in humanin-like gene regions with 50 kb flanking region
    Study

    n: not reported in source

    Outcome group
    Genetic association · Cardiovascular

    Source sentences

    Summary
    Lookup from meta-analysis datasets gave single nucleotide polymorphisms in all 13 humanin-like nuclear isoform genes with the lowest P value for rs6151662 from the MTRNR2L2 gene including the 50 kb flanking region in both directions (P-value = 0.0037).
    2 context sentences
    Summary · context
    None of the found associations were statistically significant after correction for multiple testing.
    Summary · context
    Our study looked for genomic associations between humanin-like nuclear isoform genes and coronary artery disease using CARDIoGRAMplusC4D Consortium data.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  3. 03HumanNot a test of Humanin aloneObservational studyOther

    Within the gene region alone, the top variant was rs78083998 in MTRNR2L13, with a meta-analysis P value of 0.042.

    In plain wordsWithin the gene regions, the strongest link was rs78083998 in MTRNR2L13, but it did not hold after correction.

    Peptide
    Humanin
    Outcome
    Not applicableTop variant within humanin-like gene regions
    Study

    n: not reported in source

    Outcome group
    Genetic association · Cardiovascular

    Source sentences

    Summary
    Within the gene region alone the top variant was rs78083998 from the MTRNR2L13 region (meta-analysis P-value = 0.042).
    2 context sentences
    Summary · context
    None of the found associations were statistically significant after correction for multiple testing.
    Summary · context
    Our study looked for genomic associations between humanin-like nuclear isoform genes and coronary artery disease using CARDIoGRAMplusC4D Consortium data.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  4. 04HumanNot a test of Humanin aloneObservational studyOther

    Lookup for expression trait loci in the humanin-like nuclear isoform gene regions gave no statistically significant variants.

    In plain wordsNo variant in these gene regions was significantly linked to changes in gene activity.

    Peptide
    Humanin
    Outcome
    No significant changeExpression trait loci in humanin-like gene regions
    Study

    n: not reported in source

    Outcome group
    Genetic association · Cardiovascular

    Source sentences

    Summary
    Lookup for expression trait loci in these gene regions gave no statistically significant variants.
    1 context sentence
    Summary · context
    Our study looked for genomic associations between humanin-like nuclear isoform genes and coronary artery disease using CARDIoGRAMplusC4D Consortium data.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

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