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Study · In vitro (cells) · 2020

1 result

Cardiomyocyte Sirt (Sirtuin) 7 Ameliorates Stress-Induced Cardiac Hypertrophy by Interacting With and Deacetylating GATA4.

Yamamura S, Izumiya Y, Araki S, Nakamura T, Kimura Y, Hanatani S, Yamada T, Ishida T, Yamamoto M, Onoue Y, Arima Y, Yamamoto E and 10 more

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Sunagawa Y, Yoshizawa T, Nakagata N, Bober E, Braun T, Sakamoto K, Kaikita K, Morimoto T, Yamagata K, Tsujita K

Hypertension (Dallas, Tex. : 1979)18 Nov 2019Cited by 103 (Europe PMC)

PMID31735083 (opens in a new tab)DOI10.1161/hypertensionaha.119.13357 (opens in a new tab)PepBankPUB-31735083
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In vitro, NMN ameliorated agonist-induced cardiac hypertrophy in a Sirt7-dependent manner.

    In plain wordsIn cells, NMN reduced agonist-induced cardiac hypertrophy through a process that depended on Sirt7.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseAgonist-induced cardiac hypertrophy
    Study

    n: not reported in source

    cardiomyocytes
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Interestingly, we demonstrated that treatment with nicotinamide mononucleotide, a known key NAD+ intermediate, ameliorated agonist-induced cardiac hypertrophies in a Sirt7-dependent manner in vitro.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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