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Study · In vitro (cells) · 2019

10 results

Suppression of Carnosine on Adhesion and Extravasation of Human Colorectal Cancer Cells.

Wu CC, Lai PY, Hsieh S, Cheng CC, Hsieh SL

Anticancer research1 Nov 2019Cited by 12 (Europe PMC)

PMID31704841 (opens in a new tab)DOI10.21873/anticanres.13821 (opens in a new tab)PepBankPUB-31704841
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    Carnosine reduced HCT-116 cell adhesion to EA.hy926 cells.

    In plain wordsIn cells, carnosine reduced colorectal cancer cell adhesion to vein cells.

    Peptide
    L-carnosine
    Outcome
    DecreaseCancer cell adhesion
    Study

    humann: not reported in source

    HCT-116 and EA.hy926 cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Carnosine reduced the ability of HCT-116 cells to adhere to EA.hy926 cells.
    1 context sentence
    Summary · context
    Cell adhesion and extravasation abilities, and related regulating molecular mechanisms were analyzed in human colorectal cancer cells (HCT-116) and human umbilical vein cells (EA.hy926).
  2. 02LabIn vitro (cells)Mechanism

    Carnosine reduced integrin-β1 expression in HCT-116 cells.

    In plain wordsIn cells, carnosine reduced integrin-β1 in colorectal cancer cells.

    Peptide
    L-carnosine
    Outcome
    DecreaseIntegrin-β1 expression
    Study

    humann: not reported in source

    HCT-116 and EA.hy926 cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The expression levels of integrin-β1 in HCT-116 cells, as well as of intercellular adhesion molecule-1 and E-selectin in EA.hy926 cells, were reduced after carnosine treatment.
    1 context sentence
    Summary · context
    Cell adhesion and extravasation abilities, and related regulating molecular mechanisms were analyzed in human colorectal cancer cells (HCT-116) and human umbilical vein cells (EA.hy926).
  3. 03LabIn vitro (cells)Mechanism

    Carnosine reduced intercellular adhesion molecule-1 expression in EA.hy926 cells.

    In plain wordsIn cells, carnosine reduced intercellular adhesion molecule-1 in vein cells.

    Peptide
    L-carnosine
    Outcome
    DecreaseIntercellular adhesion molecule-1 expression
    Study

    humann: not reported in source

    HCT-116 and EA.hy926 cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The expression levels of integrin-β1 in HCT-116 cells, as well as of intercellular adhesion molecule-1 and E-selectin in EA.hy926 cells, were reduced after carnosine treatment.
    1 context sentence
    Summary · context
    Cell adhesion and extravasation abilities, and related regulating molecular mechanisms were analyzed in human colorectal cancer cells (HCT-116) and human umbilical vein cells (EA.hy926).
  4. 04LabIn vitro (cells)Mechanism

    Carnosine reduced E-selectin expression in EA.hy926 cells.

    In plain wordsIn cells, carnosine reduced E-selectin in vein cells.

    Peptide
    L-carnosine
    Outcome
    DecreaseE-selectin expression
    Study

    humann: not reported in source

    HCT-116 and EA.hy926 cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The expression levels of integrin-β1 in HCT-116 cells, as well as of intercellular adhesion molecule-1 and E-selectin in EA.hy926 cells, were reduced after carnosine treatment.
    1 context sentence
    Summary · context
    Cell adhesion and extravasation abilities, and related regulating molecular mechanisms were analyzed in human colorectal cancer cells (HCT-116) and human umbilical vein cells (EA.hy926).
  5. 05LabIn vitro (cells)Mechanism

    Carnosine reduced VE-cadherin phosphorylation in EA.hy926 cells.

    In plain wordsIn cells, carnosine reduced VE-cadherin phosphorylation.

    Peptide
    L-carnosine
    Outcome
    DecreaseVE-cadherin phosphorylation
    Study

    humann: not reported in source

    HCT-116 and EA.hy926 cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    After EA.hy926 cells were treated with carnosine, phosphorylation of vascular endothelia-cadherin (VE-cadherin), protein levels of Ras homologous (RHO) and RHO-associated coiled-coil containing protein kinase, and levels of reactive oxygen species were reduced.
    1 context sentence
    Summary · context
    Cell adhesion and extravasation abilities, and related regulating molecular mechanisms were analyzed in human colorectal cancer cells (HCT-116) and human umbilical vein cells (EA.hy926).
  6. 06LabIn vitro (cells)Mechanism

    Carnosine reduced RHO protein levels in EA.hy926 cells.

    In plain wordsIn cells, carnosine reduced RHO protein levels.

    Peptide
    L-carnosine
    Outcome
    DecreaseRHO protein
    Study

    humann: not reported in source

    HCT-116 and EA.hy926 cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    After EA.hy926 cells were treated with carnosine, phosphorylation of vascular endothelia-cadherin (VE-cadherin), protein levels of Ras homologous (RHO) and RHO-associated coiled-coil containing protein kinase, and levels of reactive oxygen species were reduced.
    1 context sentence
    Summary · context
    Cell adhesion and extravasation abilities, and related regulating molecular mechanisms were analyzed in human colorectal cancer cells (HCT-116) and human umbilical vein cells (EA.hy926).
  7. 07LabIn vitro (cells)Mechanism

    Carnosine reduced RHO-associated coiled-coil containing protein kinase levels in EA.hy926 cells.

    In plain wordsIn cells, carnosine reduced RHO-associated kinase protein levels.

    Peptide
    L-carnosine
    Outcome
    DecreaseRHO-associated kinase protein
    Study

    humann: not reported in source

    HCT-116 and EA.hy926 cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    After EA.hy926 cells were treated with carnosine, phosphorylation of vascular endothelia-cadherin (VE-cadherin), protein levels of Ras homologous (RHO) and RHO-associated coiled-coil containing protein kinase, and levels of reactive oxygen species were reduced.
    1 context sentence
    Summary · context
    Cell adhesion and extravasation abilities, and related regulating molecular mechanisms were analyzed in human colorectal cancer cells (HCT-116) and human umbilical vein cells (EA.hy926).
  8. 08LabIn vitro (cells)Mechanism

    Carnosine reduced reactive oxygen species in EA.hy926 cells.

    In plain wordsIn cells, carnosine reduced reactive oxygen species.

    Peptide
    L-carnosine
    Outcome
    DecreaseReactive oxygen species
    Study

    humann: not reported in source

    HCT-116 and EA.hy926 cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    After EA.hy926 cells were treated with carnosine, phosphorylation of vascular endothelia-cadherin (VE-cadherin), protein levels of Ras homologous (RHO) and RHO-associated coiled-coil containing protein kinase, and levels of reactive oxygen species were reduced.
    1 context sentence
    Summary · context
    Cell adhesion and extravasation abilities, and related regulating molecular mechanisms were analyzed in human colorectal cancer cells (HCT-116) and human umbilical vein cells (EA.hy926).
  9. 09LabIn vitro (cells)Mechanism

    Carnosine reduced IκB phosphorylation in EA.hy926 cells.

    In plain wordsIn cells, carnosine reduced IκB phosphorylation.

    Peptide
    L-carnosine
    Outcome
    DecreaseIκB phosphorylation
    Study

    humann: not reported in source

    HCT-116 and EA.hy926 cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    After treating EA.hy926 cells with carnosine, phosphorylation of inhibitor of kappa B (IκB) and DNA binding activity of nuclear factor-κB (NF-κB) were reduced.
    1 context sentence
    Summary · context
    Cell adhesion and extravasation abilities, and related regulating molecular mechanisms were analyzed in human colorectal cancer cells (HCT-116) and human umbilical vein cells (EA.hy926).
  10. 10LabIn vitro (cells)Mechanism

    Carnosine reduced NF-κB DNA binding activity in EA.hy926 cells.

    In plain wordsIn cells, carnosine reduced NF-κB DNA binding activity.

    Peptide
    L-carnosine
    Outcome
    DecreaseNF-κB DNA binding
    Study

    humann: not reported in source

    HCT-116 and EA.hy926 cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    After treating EA.hy926 cells with carnosine, phosphorylation of inhibitor of kappa B (IκB) and DNA binding activity of nuclear factor-κB (NF-κB) were reduced.
    1 context sentence
    Summary · context
    Cell adhesion and extravasation abilities, and related regulating molecular mechanisms were analyzed in human colorectal cancer cells (HCT-116) and human umbilical vein cells (EA.hy926).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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