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Study · Non-randomized trial · n = 10 · 2020

14 results

Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men.

Irie J, Inagaki E, Fujita M, Nakaya H, Mitsuishi M, Yamaguchi S, Yamashita K, Shigaki S, Ono T, Yukioka H, Okano H, Nabeshima YI and 4 more

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Imai SI, Yasui M, Tsubota K, Itoh H

Endocrine journal2 Nov 2019Cited by 153 (Europe PMC)

PMID31685720 (opens in a new tab)DOI10.1507/endocrj.ej19-0313 (opens in a new tab)PepBankPUB-31685720
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study14

14 results from studies that gave the peptide. 14 results from people.

  1. 01HumanNon-randomized trialSafety outcome

    In healthy men, single oral NMN administrations caused no significant clinical symptoms.

    In plain wordsIn healthy men, single oral NMN doses caused no significant clinical symptoms.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    No significant changeClinical symptoms
    Study

    n = 10

    Comparator
    Before intervention
    Outcome group
    Adverse events · Whole body
    Studied dose
    100, 250, and 500 mg · oralAs given in this study (human).

    Source sentences

    Summary
    The single oral administrations of NMN did not cause any significant clinical symptoms or changes in heart rate, blood pressure, oxygen saturation, and body temperature.
    2 context sentences
    Summary · context
    We, therefore, conducted a clinical trial to investigate the safety of single NMN administration in 10 healthy men.
    Summary · context
    A single-arm non-randomized intervention was conducted by single oral administration of 100, 250, and 500 mg NMN.
  2. 02HumanNon-randomized trialSafety outcome

    In healthy men, heart rate did not change significantly after single oral NMN doses.

    In plain wordsIn healthy men, heart rate did not change significantly after single oral NMN doses.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    No significant changeHeart rate
    Study

    n = 10

    Comparator
    Before intervention
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    100, 250, and 500 mg · oralAs given in this study (human).

    Source sentences

    Summary
    The single oral administrations of NMN did not cause any significant clinical symptoms or changes in heart rate, blood pressure, oxygen saturation, and body temperature.
    2 context sentences
    Summary · context
    We, therefore, conducted a clinical trial to investigate the safety of single NMN administration in 10 healthy men.
    Summary · context
    A single-arm non-randomized intervention was conducted by single oral administration of 100, 250, and 500 mg NMN.
  3. 03HumanNon-randomized trialSafety outcome

    In healthy men, blood pressure did not change significantly after single oral NMN doses.

    In plain wordsIn healthy men, blood pressure did not change significantly after single oral NMN doses.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    No significant changeBlood pressure
    Study

    n = 10

    Comparator
    Before intervention
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    100, 250, and 500 mg · oralAs given in this study (human).

    Source sentences

    Summary
    The single oral administrations of NMN did not cause any significant clinical symptoms or changes in heart rate, blood pressure, oxygen saturation, and body temperature.
    2 context sentences
    Summary · context
    We, therefore, conducted a clinical trial to investigate the safety of single NMN administration in 10 healthy men.
    Summary · context
    A single-arm non-randomized intervention was conducted by single oral administration of 100, 250, and 500 mg NMN.
  4. 04HumanNon-randomized trialSafety outcome

    In healthy men, oxygen saturation did not change significantly after single oral NMN doses.

    In plain wordsIn healthy men, oxygen saturation did not change significantly after single oral NMN doses.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    No significant changeOxygen saturation
    Study

    n = 10

    Comparator
    Before intervention
    Outcome group
    Adverse events · Respiratory
    Studied dose
    100, 250, and 500 mg · oralAs given in this study (human).

    Source sentences

    Summary
    The single oral administrations of NMN did not cause any significant clinical symptoms or changes in heart rate, blood pressure, oxygen saturation, and body temperature.
    2 context sentences
    Summary · context
    We, therefore, conducted a clinical trial to investigate the safety of single NMN administration in 10 healthy men.
    Summary · context
    A single-arm non-randomized intervention was conducted by single oral administration of 100, 250, and 500 mg NMN.
  5. 05HumanNon-randomized trialSafety outcome

    In healthy men, body temperature did not change significantly after single oral NMN doses.

    In plain wordsIn healthy men, body temperature did not change significantly after single oral NMN doses.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    No significant changeBody temperature
    Study

    n = 10

    Comparator
    Before intervention
    Outcome group
    Adverse events · Whole body
    Studied dose
    100, 250, and 500 mg · oralAs given in this study (human).

    Source sentences

    Summary
    The single oral administrations of NMN did not cause any significant clinical symptoms or changes in heart rate, blood pressure, oxygen saturation, and body temperature.
    2 context sentences
    Summary · context
    We, therefore, conducted a clinical trial to investigate the safety of single NMN administration in 10 healthy men.
    Summary · context
    A single-arm non-randomized intervention was conducted by single oral administration of 100, 250, and 500 mg NMN.
  6. 06HumanNon-randomized trialSafety outcome

    In healthy men, serum bilirubin increased within normal ranges after NMN, independently of dose.

    In plain wordsIn healthy men, serum bilirubin increased within normal ranges after NMN, independently of dose.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseSerum bilirubin
    Study

    n = 10

    Comparator
    Before intervention
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    100, 250, and 500 mg · oralAs given in this study (human).

    Source sentences

    Summary
    Laboratory analysis results did not show significant changes, except for increases in serum bilirubin levels and decreases in serum creatinine, chloride, and blood glucose levels within the normal ranges, independent of the dose of NMN.
    2 context sentences
    Summary · context
    We, therefore, conducted a clinical trial to investigate the safety of single NMN administration in 10 healthy men.
    Summary · context
    A single-arm non-randomized intervention was conducted by single oral administration of 100, 250, and 500 mg NMN.
  7. 07HumanNon-randomized trialSafety outcome

    In healthy men, serum creatinine decreased within normal ranges after NMN, independently of dose.

    In plain wordsIn healthy men, serum creatinine decreased within normal ranges after NMN, independently of dose.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseSerum creatinine
    Study

    n = 10

    Comparator
    Before intervention
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    100, 250, and 500 mg · oralAs given in this study (human).

    Source sentences

    Summary
    Laboratory analysis results did not show significant changes, except for increases in serum bilirubin levels and decreases in serum creatinine, chloride, and blood glucose levels within the normal ranges, independent of the dose of NMN.
    2 context sentences
    Summary · context
    We, therefore, conducted a clinical trial to investigate the safety of single NMN administration in 10 healthy men.
    Summary · context
    A single-arm non-randomized intervention was conducted by single oral administration of 100, 250, and 500 mg NMN.
  8. 08HumanNon-randomized trialSafety outcome

    In healthy men, serum chloride decreased within normal ranges after NMN, independently of dose.

    In plain wordsIn healthy men, serum chloride decreased within normal ranges after NMN, independently of dose.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseSerum chloride
    Study

    n = 10

    Comparator
    Before intervention
    Outcome group
    Adverse events · Whole body
    Studied dose
    100, 250, and 500 mg · oralAs given in this study (human).

    Source sentences

    Summary
    Laboratory analysis results did not show significant changes, except for increases in serum bilirubin levels and decreases in serum creatinine, chloride, and blood glucose levels within the normal ranges, independent of the dose of NMN.
    2 context sentences
    Summary · context
    We, therefore, conducted a clinical trial to investigate the safety of single NMN administration in 10 healthy men.
    Summary · context
    A single-arm non-randomized intervention was conducted by single oral administration of 100, 250, and 500 mg NMN.
  9. 09HumanNon-randomized trialSafety outcome

    In healthy men, blood glucose decreased within normal ranges after NMN, independently of dose.

    In plain wordsIn healthy men, blood glucose decreased within normal ranges after NMN, independently of dose.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseBlood glucose
    Study

    n = 10

    Comparator
    Before intervention
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    100, 250, and 500 mg · oralAs given in this study (human).

    Source sentences

    Summary
    Laboratory analysis results did not show significant changes, except for increases in serum bilirubin levels and decreases in serum creatinine, chloride, and blood glucose levels within the normal ranges, independent of the dose of NMN.
    2 context sentences
    Summary · context
    We, therefore, conducted a clinical trial to investigate the safety of single NMN administration in 10 healthy men.
    Summary · context
    A single-arm non-randomized intervention was conducted by single oral administration of 100, 250, and 500 mg NMN.
  10. 10HumanNon-randomized trialSafety outcome

    In healthy men, ophthalmic examination results showed no differences before and after NMN.

    In plain wordsIn healthy men, eye examination results did not differ before and after NMN.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    No significant changeOphthalmic examination
    Study

    n = 10

    Comparator
    Before intervention
    Outcome group
    Adverse events · Eye
    Studied dose
    100, 250, and 500 mg · oralAs given in this study (human).

    Source sentences

    Summary
    Results of ophthalmic examination and sleep quality score showed no differences before and after the intervention.
    2 context sentences
    Summary · context
    We, therefore, conducted a clinical trial to investigate the safety of single NMN administration in 10 healthy men.
    Summary · context
    A single-arm non-randomized intervention was conducted by single oral administration of 100, 250, and 500 mg NMN.
  11. 11HumanNon-randomized trialSafety outcome

    In healthy men, sleep quality scores showed no differences before and after NMN.

    In plain wordsIn healthy men, sleep quality scores did not differ before and after NMN.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    No significant changeSleep quality score
    Study

    n = 10

    Comparator
    Before intervention
    Outcome group
    Sleep · Sleep
    Studied dose
    100, 250, and 500 mg · oralAs given in this study (human).

    Source sentences

    Summary
    Results of ophthalmic examination and sleep quality score showed no differences before and after the intervention.
    2 context sentences
    Summary · context
    We, therefore, conducted a clinical trial to investigate the safety of single NMN administration in 10 healthy men.
    Summary · context
    A single-arm non-randomized intervention was conducted by single oral administration of 100, 250, and 500 mg NMN.
  12. 12HumanNon-randomized trialPharmacokinetics

    In healthy men, NMN dose-dependently increased plasma N-methyl-2-pyridone-5-carboxamide concentrations.

    In plain wordsIn healthy men, NMN increased plasma N-methyl-2-pyridone-5-carboxamide concentrations as the dose increased.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreasePlasma N-methyl-2-pyridone-5-carboxamide
    Study

    n = 10

    Comparator
    Before intervention
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    100, 250, and 500 mg · oralAs given in this study (human).

    Source sentences

    Summary
    Plasma concentrations of N-methyl-2-pyridone-5-carboxamide and N-methyl-4-pyridone-5-carboxamide were significantly increased dose-dependently by NMN administration.
    2 context sentences
    Summary · context
    We, therefore, conducted a clinical trial to investigate the safety of single NMN administration in 10 healthy men.
    Summary · context
    A single-arm non-randomized intervention was conducted by single oral administration of 100, 250, and 500 mg NMN.
  13. 13HumanNon-randomized trialPharmacokinetics

    In healthy men, NMN dose-dependently increased plasma N-methyl-4-pyridone-5-carboxamide concentrations.

    In plain wordsIn healthy men, NMN increased plasma N-methyl-4-pyridone-5-carboxamide concentrations as the dose increased.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreasePlasma N-methyl-4-pyridone-5-carboxamide
    Study

    n = 10

    Comparator
    Before intervention
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    100, 250, and 500 mg · oralAs given in this study (human).

    Source sentences

    Summary
    Plasma concentrations of N-methyl-2-pyridone-5-carboxamide and N-methyl-4-pyridone-5-carboxamide were significantly increased dose-dependently by NMN administration.
    2 context sentences
    Summary · context
    We, therefore, conducted a clinical trial to investigate the safety of single NMN administration in 10 healthy men.
    Summary · context
    A single-arm non-randomized intervention was conducted by single oral administration of 100, 250, and 500 mg NMN.
  14. 14HumanNon-randomized trialSafety outcome

    In healthy men, laboratory results showed no significant changes after NMN except bilirubin, creatinine, chloride, and blood glucose changes within normal ranges.

    In plain wordsIn healthy men, other laboratory results showed no significant changes after NMN, apart from bilirubin, creatinine, chloride, and blood glucose.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    No significant changeOther laboratory analysis results
    Study

    n = 10

    Comparator
    Before intervention
    Outcome group
    Adverse events · Whole body
    Studied dose
    100, 250, and 500 mg · oralAs given in this study (human).

    Source sentences

    Summary
    Laboratory analysis results did not show significant changes, except for increases in serum bilirubin levels and decreases in serum creatinine, chloride, and blood glucose levels within the normal ranges, independent of the dose of NMN.
    2 context sentences
    Summary · context
    We, therefore, conducted a clinical trial to investigate the safety of single NMN administration in 10 healthy men.
    Summary · context
    A single-arm non-randomized intervention was conducted by single oral administration of 100, 250, and 500 mg NMN.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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