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Study · Animal study (in vivo) · mouse · 2019

22 results

Carnosine exerts antitumor activity against bladder cancers in vitro and in vivo via suppression of angiogenesis.

Hwang B, Shin SS, Song JH, Choi YH, Kim WJ, Moon SK

The Journal of nutritional biochemistry1 Sept 2019Cited by 16 (Europe PMC)

PMID31683101 (opens in a new tab)DOI10.1016/j.jnutbio.2019.108230 (opens in a new tab)PepBankPUB-31683101
Publisher pagePubMedAsk about this study
Jump to 22 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study22

22 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In EJ-xenografted mice, carnosine exhibited antitumor activity equivalent to cisplatin.

    In plain wordsIn mice, carnosine showed antitumor activity equivalent to cisplatin.

    Peptide
    L-carnosine
    Outcome
    No significant changeXenograft antitumor activity
    Study

    mousen: not reported in source

    EJ-xenografted BALB/c nude mice
    Comparator
    cisplatin
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In xenograft tumors, carnosine exhibited antitumor activity equivalent to cisplatin, but no weight loss occurred in carnosine-treated mice.
    1 context sentence
    Summary · context
    In this study, we evaluated the in vitro and in vivo antitumor effects of carnosine in EJ bladder cancer cells and EJ-xenografted BALB/c nude mice, respectively.
  2. 02AnimalAnimal study (in vivo)Safety outcome

    No weight loss occurred in carnosine-treated EJ-xenografted mice.

    In plain wordsIn mice with bladder cancer xenografts, no weight loss occurred during carnosine treatment.

    Peptide
    L-carnosine
    Outcome
    No significant changeWeight loss
    Study

    mousen: not reported in source

    EJ-xenografted BALB/c nude mice
    Outcome group
    Body weight · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In xenograft tumors, carnosine exhibited antitumor activity equivalent to cisplatin, but no weight loss occurred in carnosine-treated mice.
    1 context sentence
    Summary · context
    In this study, we evaluated the in vitro and in vivo antitumor effects of carnosine in EJ bladder cancer cells and EJ-xenografted BALB/c nude mice, respectively.
  3. 03AnimalAnimal study (in vivo)Activity measurement

    Carnosine showed antiangiogenic activity in the in vivo Matrigel plug assay.

    In plain wordsIn animals, carnosine inhibited angiogenesis in a Matrigel plug assay.

    Peptide
    L-carnosine
    Outcome
    DecreaseMatrigel plug angiogenesis
    Study

    n: not reported in source

    Matrigel plug assay
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, using aortic ring and Matrigel plug assays, we confirmed the antiangiogenic activity of carnosine.
    1 context sentence
    Summary · context
    In addition, in vitro capillary tube formation of HUVECs, ex vivo aortic ring and in vivo Matrigel plug assays were employed to examine the antiangiogenic potential of carnosine.
  4. 04LabEx vivo tissueActivity measurement

    Carnosine showed antiangiogenic activity in the aortic ring assay.

    In plain wordsIn lab tests, carnosine inhibited angiogenesis in an aortic ring assay.

    Peptide
    L-carnosine
    Outcome
    DecreaseAortic ring angiogenesis
    Study

    n: not reported in source

    aortic ring assay
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, using aortic ring and Matrigel plug assays, we confirmed the antiangiogenic activity of carnosine.
    1 context sentence
    Summary · context
    In addition, in vitro capillary tube formation of HUVECs, ex vivo aortic ring and in vivo Matrigel plug assays were employed to examine the antiangiogenic potential of carnosine.
  5. 05LabIn vitro (cells)Efficacy outcome

    Carnosine significantly inhibited EJ bladder cancer cell proliferation.

    In plain wordsIn cells, carnosine significantly reduced bladder cancer cell growth.

    Peptide
    L-carnosine
    Outcome
    DecreaseEJ cell proliferation
    Study

    n: not reported in source

    EJ bladder cancer cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Carnosine significantly inhibited EJ cell proliferation.
    1 context sentence
    Summary · context
    In this study, we evaluated the in vitro and in vivo antitumor effects of carnosine in EJ bladder cancer cells and EJ-xenografted BALB/c nude mice, respectively.
  6. 06LabIn vitro (cells)Mechanism

    In EJ cells, carnosine modulated G1 cell cycle regulators, including cyclin D1, CDK4 and p21WAF1.

    In plain wordsIn cells, carnosine changed regulators of the G1 cell cycle phase.

    Peptide
    L-carnosine
    Outcome
    Direction not reportedG1 cell cycle regulators
    Study

    n: not reported in source

    EJ bladder cancer cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Flow cytometric and immunoblot analyses indicated that carnosine modulated regulators of the G1 cell cycle phase, including cyclin D1, CDK4 and p21WAF1.
    1 context sentence
    Summary · context
    In this study, we evaluated the in vitro and in vivo antitumor effects of carnosine in EJ bladder cancer cells and EJ-xenografted BALB/c nude mice, respectively.
  7. 07LabIn vitro (cells)Mechanism

    In EJ cells, ERK responded to carnosine.

    In plain wordsIn cells, ERK responded to carnosine.

    Peptide
    L-carnosine
    Outcome
    Direction not reportedERK response
    Study

    n: not reported in source

    EJ bladder cancer cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The mitogen-activated protein kinases, ERK and p38, but not JNK or AKT, responded to carnosine.
    1 context sentence
    Summary · context
    In this study, we evaluated the in vitro and in vivo antitumor effects of carnosine in EJ bladder cancer cells and EJ-xenografted BALB/c nude mice, respectively.
  8. 08LabIn vitro (cells)Mechanism

    In EJ cells, p38 responded to carnosine.

    In plain wordsIn cells, p38 responded to carnosine.

    Peptide
    L-carnosine
    Outcome
    Direction not reportedp38 response
    Study

    n: not reported in source

    EJ bladder cancer cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The mitogen-activated protein kinases, ERK and p38, but not JNK or AKT, responded to carnosine.
    1 context sentence
    Summary · context
    In this study, we evaluated the in vitro and in vivo antitumor effects of carnosine in EJ bladder cancer cells and EJ-xenografted BALB/c nude mice, respectively.
  9. 09LabIn vitro (cells)Mechanism

    In EJ cells, JNK did not respond to carnosine.

    In plain wordsIn cells, JNK did not respond to carnosine.

    Peptide
    L-carnosine
    Outcome
    No significant changeJNK response
    Study

    n: not reported in source

    EJ bladder cancer cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The mitogen-activated protein kinases, ERK and p38, but not JNK or AKT, responded to carnosine.
    1 context sentence
    Summary · context
    In this study, we evaluated the in vitro and in vivo antitumor effects of carnosine in EJ bladder cancer cells and EJ-xenografted BALB/c nude mice, respectively.
  10. 10LabIn vitro (cells)Mechanism

    In EJ cells, AKT did not respond to carnosine.

    In plain wordsIn cells, AKT did not respond to carnosine.

    Peptide
    L-carnosine
    Outcome
    No significant changeAKT response
    Study

    n: not reported in source

    EJ bladder cancer cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The mitogen-activated protein kinases, ERK and p38, but not JNK or AKT, responded to carnosine.
    1 context sentence
    Summary · context
    In this study, we evaluated the in vitro and in vivo antitumor effects of carnosine in EJ bladder cancer cells and EJ-xenografted BALB/c nude mice, respectively.
  11. 11LabIn vitro (cells)Efficacy outcome

    Carnosine inhibited EJ cell migration.

    In plain wordsIn cells, carnosine reduced bladder cancer cell migration.

    Peptide
    L-carnosine
    Outcome
    DecreaseEJ cell migration
    Study

    n: not reported in source

    EJ bladder cancer cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Carnosine inhibited the migratory and invasive potential of EJ cells by inhibiting MMP-9 activity, which was associated with suppression of binding activity of NF-κB, SP-1 and AP-1.
    1 context sentence
    Summary · context
    In this study, we evaluated the in vitro and in vivo antitumor effects of carnosine in EJ bladder cancer cells and EJ-xenografted BALB/c nude mice, respectively.
  12. 12LabIn vitro (cells)Efficacy outcome

    Carnosine inhibited EJ cell invasion.

    In plain wordsIn cells, carnosine reduced bladder cancer cell invasion.

    Peptide
    L-carnosine
    Outcome
    DecreaseEJ cell invasion
    Study

    n: not reported in source

    EJ bladder cancer cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Carnosine inhibited the migratory and invasive potential of EJ cells by inhibiting MMP-9 activity, which was associated with suppression of binding activity of NF-κB, SP-1 and AP-1.
    1 context sentence
    Summary · context
    In this study, we evaluated the in vitro and in vivo antitumor effects of carnosine in EJ bladder cancer cells and EJ-xenografted BALB/c nude mice, respectively.
  13. 13LabIn vitro (cells)Mechanism

    Carnosine inhibited MMP-9 activity in EJ cells.

    In plain wordsIn cells, carnosine reduced MMP-9 activity.

    Peptide
    L-carnosine
    Outcome
    DecreaseMMP-9 activity
    Study

    n: not reported in source

    EJ bladder cancer cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Carnosine inhibited the migratory and invasive potential of EJ cells by inhibiting MMP-9 activity, which was associated with suppression of binding activity of NF-κB, SP-1 and AP-1.
    1 context sentence
    Summary · context
    In this study, we evaluated the in vitro and in vivo antitumor effects of carnosine in EJ bladder cancer cells and EJ-xenografted BALB/c nude mice, respectively.
  14. 14LabIn vitro (cells)Mechanism

    In EJ cells, carnosine-associated MMP-9 inhibition accompanied suppression of NF-κB binding activity.

    In plain wordsIn cells, carnosine-associated MMP-9 inhibition accompanied lower NF-κB binding activity.

    Peptide
    L-carnosine
    Outcome
    DecreaseNF-κB binding activity
    Study

    n: not reported in source

    EJ bladder cancer cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Carnosine inhibited the migratory and invasive potential of EJ cells by inhibiting MMP-9 activity, which was associated with suppression of binding activity of NF-κB, SP-1 and AP-1.
    1 context sentence
    Summary · context
    In this study, we evaluated the in vitro and in vivo antitumor effects of carnosine in EJ bladder cancer cells and EJ-xenografted BALB/c nude mice, respectively.
  15. 15LabIn vitro (cells)Mechanism

    In EJ cells, carnosine-associated MMP-9 inhibition accompanied suppression of SP-1 binding activity.

    In plain wordsIn cells, carnosine-associated MMP-9 inhibition accompanied lower SP-1 binding activity.

    Peptide
    L-carnosine
    Outcome
    DecreaseSP-1 binding activity
    Study

    n: not reported in source

    EJ bladder cancer cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Carnosine inhibited the migratory and invasive potential of EJ cells by inhibiting MMP-9 activity, which was associated with suppression of binding activity of NF-κB, SP-1 and AP-1.
    1 context sentence
    Summary · context
    In this study, we evaluated the in vitro and in vivo antitumor effects of carnosine in EJ bladder cancer cells and EJ-xenografted BALB/c nude mice, respectively.
  16. 16LabIn vitro (cells)Mechanism

    In EJ cells, carnosine-associated MMP-9 inhibition accompanied suppression of AP-1 binding activity.

    In plain wordsIn cells, carnosine-associated MMP-9 inhibition accompanied lower AP-1 binding activity.

    Peptide
    L-carnosine
    Outcome
    DecreaseAP-1 binding activity
    Study

    n: not reported in source

    EJ bladder cancer cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Carnosine inhibited the migratory and invasive potential of EJ cells by inhibiting MMP-9 activity, which was associated with suppression of binding activity of NF-κB, SP-1 and AP-1.
    1 context sentence
    Summary · context
    In this study, we evaluated the in vitro and in vivo antitumor effects of carnosine in EJ bladder cancer cells and EJ-xenografted BALB/c nude mice, respectively.
  17. 17LabIn vitro (cells)Efficacy outcome

    In HUVECs, carnosine inhibited VEGF-mediated proliferation.

    In plain wordsIn cells, carnosine reduced VEGF-mediated proliferation.

    Peptide
    L-carnosine
    Outcome
    DecreaseVEGF-mediated proliferation
    Study

    humann: not reported in source

    HUVECs
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In HUVECs, carnosine inhibited VEGF-mediated proliferation, colony tube formation, migration and invasion.
    1 context sentence
    Summary · context
    In this study, we evaluated the in vitro and in vivo antitumor effects of carnosine in EJ bladder cancer cells and EJ-xenografted BALB/c nude mice, respectively.
  18. 18LabIn vitro (cells)Efficacy outcome

    In HUVECs, carnosine inhibited colony tube formation.

    In plain wordsIn cells, carnosine reduced colony tube formation.

    Peptide
    L-carnosine
    Outcome
    DecreaseColony tube formation
    Study

    humann: not reported in source

    HUVECs
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In HUVECs, carnosine inhibited VEGF-mediated proliferation, colony tube formation, migration and invasion.
    1 context sentence
    Summary · context
    In this study, we evaluated the in vitro and in vivo antitumor effects of carnosine in EJ bladder cancer cells and EJ-xenografted BALB/c nude mice, respectively.
  19. 19LabIn vitro (cells)Efficacy outcome

    In HUVECs, carnosine inhibited migration.

    In plain wordsIn cells, carnosine reduced HUVEC migration.

    Peptide
    L-carnosine
    Outcome
    DecreaseHUVEC migration
    Study

    humann: not reported in source

    HUVECs
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In HUVECs, carnosine inhibited VEGF-mediated proliferation, colony tube formation, migration and invasion.
    1 context sentence
    Summary · context
    In this study, we evaluated the in vitro and in vivo antitumor effects of carnosine in EJ bladder cancer cells and EJ-xenografted BALB/c nude mice, respectively.
  20. 20LabIn vitro (cells)Efficacy outcome

    In HUVECs, carnosine inhibited invasion.

    In plain wordsIn cells, carnosine reduced HUVEC invasion.

    Peptide
    L-carnosine
    Outcome
    DecreaseHUVEC invasion
    Study

    humann: not reported in source

    HUVECs
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In HUVECs, carnosine inhibited VEGF-mediated proliferation, colony tube formation, migration and invasion.
    1 context sentence
    Summary · context
    In this study, we evaluated the in vitro and in vivo antitumor effects of carnosine in EJ bladder cancer cells and EJ-xenografted BALB/c nude mice, respectively.
  21. 21LabIn vitro (cells)Mechanism

    Carnosine antiangiogenic activity involved suppression of VEGFR-2-mediated ERK/AKT/eNOS signaling.

    In plain wordsIn lab tests, carnosine antiangiogenic activity involved lower VEGFR-2-mediated ERK/AKT/eNOS signaling.

    Peptide
    L-carnosine
    Outcome
    DecreaseVEGFR-2-mediated ERK/AKT/eNOS signaling
    Study

    humann: not reported in source

    HUVECs
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The antiangiogenic activity of carnosine was partially due to the suppression of VEGFR-2-mediated ERK/AKT/eNOS signaling and MMP-2.
  22. 22LabIn vitro (cells)Mechanism

    Carnosine antiangiogenic activity involved suppression of MMP-2.

    In plain wordsIn lab tests, carnosine antiangiogenic activity involved lower MMP-2.

    Peptide
    L-carnosine
    Outcome
    DecreaseMMP-2 suppression
    Study

    humann: not reported in source

    HUVECs
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The antiangiogenic activity of carnosine was partially due to the suppression of VEGFR-2-mediated ERK/AKT/eNOS signaling and MMP-2.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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