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Study · Non-randomized trial · n = 83 · 2019

4 results

The Effects of Gonadotropin-Releasing Hormone Analog and a Combination of Gonadotropin-Releasing Hormone Analog and Recombinant Human Growth Hormone on Adult Height in Girls with Early Puberty.

Hajzadeh G, Ghaemi N, Hadjzadeh MA, Noroozi S, Morovatdar N

Advanced biomedical research23 Sept 2019Cited by 6 (Europe PMC)

PMID31673530 (opens in a new tab)PMCIDPMC6777143 (opens in a new tab)DOI10.4103/abr.abr_121_19 (opens in a new tab)PepBankPUB-31673530
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study4

1 result from studies that gave the peptide. 1 result from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In girls with early puberty, predicted adult height after triptorelin did not differ from untreated girls.

    In plain wordsIn girls with early puberty, predicted adult height after triptorelin did not differ from untreated girls.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changePredicted adult height versus untreated girls
    Study

    n = 83

    Comparator
    Untreated girls
    Outcome group
    Linear growth · Endocrine and hormones
    Studied dose
    100 μg/kg every 28 days · intramuscular · 2.82 ± 0.57 yearsAs given in this study (human).

    Source sentences

    Summary
    PAH at the end of the study in the GnRHa group was not different with untreated girls.
    2 context sentences
    Summary · context
    Fifty EP girls (sexual maturity rating: 2-3) with chronological age (CA) 9.22 ± 0.56 and bone age (BA) 9.74 ± 0.59 years were treated with GnRHa (Triptorelin) at a dose of 100 μg/kg body weight (BW) as intramuscular every 28 days for 2.82 ± 0.57 years;
    Summary · context
    In the control group, 33 EP girls followed for the same period without treatment.

Studies that did not test the peptide alone3

In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  1. 02HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialEfficacy outcome

    In girls with early puberty, triptorelin plus growth hormone increased predicted adult height compared with triptorelin alone.

    In plain wordsIn girls with early puberty, triptorelin plus growth hormone increased predicted adult height compared with triptorelin alone.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreasePredicted adult height with combination versus triptorelin
    Study

    n = 95

    Comparator
    Triptorelin alone
    Outcome group
    Linear growth · Endocrine and hormones

    Source sentences

    Summary
    PAH at the end of the treatment in GnRHa plus rhGH group was significantly higher than both untreated and GnRHa group.
    2 context sentences
    Summary · context
    45 EP girls with CA 9.84 ± 0.57 and BA 10.14 ± 1.02 years were also treated with the same GnRHa plus rhGH (Norditropin) at a dose of 0.1 unit/kg BW daily for 6 days in a week for 2.55 ± 0.6 years.
    Summary · context
    In the control group, 33 EP girls followed for the same period without treatment.

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  2. 03HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialEfficacy outcome

    In girls with early puberty, triptorelin plus growth hormone increased predicted adult height compared with untreated girls.

    In plain wordsIn girls with early puberty, triptorelin plus growth hormone increased predicted adult height compared with untreated girls.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreasePredicted adult height with combination versus untreated girls
    Study

    n = 78

    Comparator
    Untreated girls
    Outcome group
    Linear growth · Endocrine and hormones

    Source sentences

    Summary
    PAH at the end of the treatment in GnRHa plus rhGH group was significantly higher than both untreated and GnRHa group.
    2 context sentences
    Summary · context
    45 EP girls with CA 9.84 ± 0.57 and BA 10.14 ± 1.02 years were also treated with the same GnRHa plus rhGH (Norditropin) at a dose of 0.1 unit/kg BW daily for 6 days in a week for 2.55 ± 0.6 years.
    Summary · context
    In the control group, 33 EP girls followed for the same period without treatment.

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  3. 04HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialEfficacy outcome

    In girls with early puberty, predicted adult height after triptorelin plus growth hormone exceeded target height.

    In plain wordsIn girls with early puberty, predicted adult height after triptorelin plus growth hormone exceeded target height.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreasePredicted adult height with combination versus target height
    Study

    n = 45

    Comparator
    Target height
    Outcome group
    Linear growth · Endocrine and hormones

    Source sentences

    Summary
    PAH at the end of therapy in GnRHa plus rhGH group was significantly more than their target height.
    2 context sentences
    Summary · context
    45 EP girls with CA 9.84 ± 0.57 and BA 10.14 ± 1.02 years were also treated with the same GnRHa plus rhGH (Norditropin) at a dose of 0.1 unit/kg BW daily for 6 days in a week for 2.55 ± 0.6 years.
    Summary · context
    Predicted adult height (PAH) at the start and the end of the study and target height were assessed.

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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