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Study · Animal study (in vivo) · rat · 2020

2 results

The Nephroprotective Role of Carnosine Against Ifosfamide-Induced Renal Injury and Electrolytes Imbalance is Mediated Via the Regulation of Mitochondrial Function and Alleviation of Oxidative Stress.

Ommati MM, Farshad O, Ghanbarinejad V, Mohammadi HR, Khadijeh M, Negar A, Zahra M, Ilkhaninasab F, Moezi L, Heidari R

Drug research31 Oct 2019Cited by 13 (Europe PMC)

PMID31671464 (opens in a new tab)DOI10.1055/a-1017-5085 (opens in a new tab)PepBankPUB-31671464
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, carnosine mitigated ifosfamide-induced oxidative stress in renal tissue.

    In plain wordsIn rats, carnosine reduced kidney oxidative stress compared with ifosfamide alone.

    Peptide
    L-carnosine
    Outcome
    DecreaseRenal oxidative stress
    Study

    ratn: not reported in source

    Ifosfamide-induced renal injury
    Comparator
    Ifosfamide alone
    Outcome group
    Inflammation markers · Kidney and urinary
    Studied dose
    250 and 500 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Carnosine (250 and 500 mg/kg, i.p) mitigated IFO-induced oxidative stress and mitochondrial impairment in renal tissue.
    1 context sentence
    Summary · context
    Rats were treated with IFO (50 mg/kg, i.p) alone or in combination with carnosine.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, carnosine mitigated ifosfamide-induced mitochondrial impairment in renal tissue.

    In plain wordsIn rats, carnosine reduced kidney mitochondrial impairment compared with ifosfamide alone.

    Peptide
    L-carnosine
    Outcome
    DecreaseRenal mitochondrial impairment
    Study

    ratn: not reported in source

    Ifosfamide-induced renal injury
    Comparator
    Ifosfamide alone
    Outcome group
    Mitochondrial function · Kidney and urinary
    Studied dose
    250 and 500 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Carnosine (250 and 500 mg/kg, i.p) mitigated IFO-induced oxidative stress and mitochondrial impairment in renal tissue.
    1 context sentence
    Summary · context
    Rats were treated with IFO (50 mg/kg, i.p) alone or in combination with carnosine.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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