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Study · Not a test of the peptide alone · 2020

6 results

The humanin peptide mediates ELP nanoassembly and protects human retinal pigment epithelial cells from oxidative stress.

Li Z, Sreekumar PG, Peddi S, Hinton DR, Kannan R, MacKay JA

Nanomedicine : nanotechnology, biology, and medicine23 Oct 2019Cited by 14 (Europe PMC)

PMID31655204 (opens in a new tab)PMCIDPMC7263384 (opens in a new tab)DOI10.1016/j.nano.2019.102111 (opens in a new tab)PepBankPUB-31655204
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone6

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 01LabNot a test of Humanin aloneIn vitro (cells)Activity measurement

    Both humanin-ELP fusions bound human RPE cells.

    In plain wordsIn lab tests, both humanin fusions attached to human retinal cells.

    Peptide
    Humanin
    Outcome
    Not applicableBinding to human RPE cells
    Study

    humann: not reported in source

    Human retinal pigment epithelium cells
    Outcome group
    Receptor activity and mechanism · Eye

    Source sentences

    Summary
    Both fusions bind human RPE cells and protect against oxidative stress-induction of apoptosis (TUNEL, caspase-3 activation).

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  2. 02LabNot a test of Humanin aloneIn vitro (cells)Efficacy outcome

    In human RPE cells, both humanin-ELP fusions protected against oxidative-stress-induced apoptosis, measured by TUNEL and caspase-3 activation.

    In plain wordsIn cells, both humanin fusions protected human retinal cells from cell death caused by oxidative stress.

    Peptide
    Humanin
    Outcome
    DecreaseProtection against oxidative-stress-induced apoptosis
    Study

    humann: not reported in source

    Human retinal pigment epithelium cells
    Outcome group
    Neuroprotection · Eye

    Source sentences

    Summary
    Both fusions bind human RPE cells and protect against oxidative stress-induction of apoptosis (TUNEL, caspase-3 activation).

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  3. 03LabNot a test of Humanin aloneIn vitro (cells)Mechanism

    In human RPE cells, the activity of the humanin-ELP fusions was mediated through STAT3.

    In plain wordsIn cells, the humanin fusions worked through a signal protein called STAT3.

    Peptide
    Humanin
    Outcome
    Not applicableRole of STAT3 in fusion activity
    Study

    humann: not reported in source

    Human retinal pigment epithelium cells
    Outcome group
    Receptor activity and mechanism · Eye

    Source sentences

    Summary
    Their activity is mediated through STAT3; furthermore, STAT3 inhibition eliminates their protection.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  4. 04LabNot a test of Humanin aloneIn vitro (cells)Mechanism

    In human RPE cells, STAT3 inhibition eliminated the protection given by the humanin-ELP fusions.

    In plain wordsIn cells, blocking STAT3 removed the protection that the humanin fusions gave.

    Peptide
    Humanin
    Outcome
    DecreaseFusion protection after STAT3 inhibition
    Study

    humann: not reported in source

    Human retinal pigment epithelium cells
    Outcome group
    Neuroprotection · Eye

    Source sentences

    Summary
    Their activity is mediated through STAT3; furthermore, STAT3 inhibition eliminates their protection.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  5. 05LabNot a test of Humanin aloneIn vitro (cell-free)Other

    In cell-free assays, the soluble humanin-ELP fusion assembled stable colloids with a hydrodynamic radius of 39.1 nm at 37°C.

    In plain wordsIn lab tests, the soluble humanin fusion formed stable particles about 39.1 nm in radius at body temperature.

    Peptide
    Humanin
    Outcome
    Not applicableColloid size of soluble humanin-ELP fusion at 37°C
    Study

    n: not reported in source

    Cell-free fusion protein assay
    Outcome group
    Pharmacokinetics · Pharmacology

    Measurements

    Hydrodynamic radius
    39.1 nm
    soluble fusion, 37°C

    Source sentences

    Summary
    Interestingly, the soluble fusion assembles stable colloids with a hydrodynamic radius of 39.1 nm at 37°C.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  6. 06LabNot a test of Humanin aloneIn vitro (cell-free)Other

    In cell-free assays, the thermo-responsive humanin-ELP fusion formed large coacervates of more than 1,000 nm at 37°C.

    In plain wordsIn lab tests, the temperature-responsive humanin fusion formed large clumps above 1,000 nm at body temperature.

    Peptide
    Humanin
    Outcome
    Not applicableCoacervate size of thermo-responsive humanin-ELP fusion at 37°C
    Study

    n: not reported in source

    Cell-free fusion protein assay
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    As intended, the thermo-responsive fusion forms large coacervates (>1,000 nm) at 37°C.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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