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Study · Animal study (in vivo) · pig · 2019

6 results

Exogenous supplemental NAD+ protect myocardium against myocardial ischemic/reperfusion injury in swine model.

Zhai X, Han W, Wang M, Guan S, Qu X

American journal of translational research15 Sept 2019Cited by 22 (Europe PMC)

PMID31632574 (opens in a new tab)PMCIDPMC6789262 (opens in a new tab)PepBankPUB-31632574
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with myocardial ischemia/reperfusion, NAD+ reduced myocardial necrosis versus saline.

    In plain wordsIn pigs with myocardial ischemia/reperfusion, NAD+ reduced heart tissue death compared with saline.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    DecreaseMyocardial necrosis
    Study

    pign = 14

    Bama miniature pigs with myocardial ischemia/reperfusion
    Comparator
    Saline
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    20 mg/kgAs given in this study (pig).

    Source sentences

    Summary
    NAD+ administration markedly reduced myocardial necrosis, enhanced glucose metabolism, and promoted cardiac function recovery.
    1 context sentence
    Summary · context
    Fourteen Bama miniature pigs were subjected to 90 min transluminal balloon occlusion, and then randomly administrated with 20 mg/kg NAD+ or saline before reperfusion.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with myocardial ischemia/reperfusion, NAD+ enhanced glucose metabolism versus saline.

    In plain wordsIn pigs with myocardial ischemia/reperfusion, NAD+ enhanced glucose metabolism compared with saline.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    IncreaseGlucose metabolism
    Study

    pign = 14

    Bama miniature pigs with myocardial ischemia/reperfusion
    Comparator
    Saline
    Outcome group
    Glycemic control · Cardiovascular
    Studied dose
    20 mg/kgAs given in this study (pig).

    Source sentences

    Summary
    NAD+ administration markedly reduced myocardial necrosis, enhanced glucose metabolism, and promoted cardiac function recovery.
    1 context sentence
    Summary · context
    Fourteen Bama miniature pigs were subjected to 90 min transluminal balloon occlusion, and then randomly administrated with 20 mg/kg NAD+ or saline before reperfusion.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with myocardial ischemia/reperfusion, NAD+ promoted cardiac function recovery versus saline.

    In plain wordsIn pigs with myocardial ischemia/reperfusion, NAD+ improved heart function recovery compared with saline.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    IncreaseCardiac function recovery
    Study

    pign = 14

    Bama miniature pigs with myocardial ischemia/reperfusion
    Comparator
    Saline
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    20 mg/kgAs given in this study (pig).

    Source sentences

    Summary
    NAD+ administration markedly reduced myocardial necrosis, enhanced glucose metabolism, and promoted cardiac function recovery.
    1 context sentence
    Summary · context
    Fourteen Bama miniature pigs were subjected to 90 min transluminal balloon occlusion, and then randomly administrated with 20 mg/kg NAD+ or saline before reperfusion.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with myocardial ischemia/reperfusion, NAD+ reduced inflammation versus saline.

    In plain wordsIn pigs with myocardial ischemia/reperfusion, NAD+ reduced inflammation compared with saline.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    DecreaseInflammation
    Study

    pign = 14

    Bama miniature pigs with myocardial ischemia/reperfusion
    Comparator
    Saline
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    20 mg/kgAs given in this study (pig).

    Source sentences

    Summary
    The extent of inflammation was also reduced in the NAD+ treated animals, and corresponded to less cardiac fibrosis and better ventricular compliance.
    1 context sentence
    Summary · context
    Fourteen Bama miniature pigs were subjected to 90 min transluminal balloon occlusion, and then randomly administrated with 20 mg/kg NAD+ or saline before reperfusion.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with myocardial ischemia/reperfusion, NAD+ treatment corresponded to less cardiac fibrosis versus saline.

    In plain wordsIn pigs with myocardial ischemia/reperfusion, NAD+ treatment corresponded to less heart fibrosis compared with saline.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    DecreaseCardiac fibrosis
    Study

    pign = 14

    Bama miniature pigs with myocardial ischemia/reperfusion
    Comparator
    Saline
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    20 mg/kgAs given in this study (pig).

    Source sentences

    Summary
    The extent of inflammation was also reduced in the NAD+ treated animals, and corresponded to less cardiac fibrosis and better ventricular compliance.
    1 context sentence
    Summary · context
    Fourteen Bama miniature pigs were subjected to 90 min transluminal balloon occlusion, and then randomly administrated with 20 mg/kg NAD+ or saline before reperfusion.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with myocardial ischemia/reperfusion, NAD+ treatment corresponded to better ventricular compliance versus saline.

    In plain wordsIn pigs with myocardial ischemia/reperfusion, NAD+ treatment corresponded to better ventricular compliance compared with saline.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    IncreaseVentricular compliance
    Study

    pign = 14

    Bama miniature pigs with myocardial ischemia/reperfusion
    Comparator
    Saline
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    20 mg/kgAs given in this study (pig).

    Source sentences

    Summary
    The extent of inflammation was also reduced in the NAD+ treated animals, and corresponded to less cardiac fibrosis and better ventricular compliance.
    1 context sentence
    Summary · context
    Fourteen Bama miniature pigs were subjected to 90 min transluminal balloon occlusion, and then randomly administrated with 20 mg/kg NAD+ or saline before reperfusion.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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