Kp-10 promotes bovine mammary epithelial cell proliferation by activating GPR54 and its downstream signaling pathways.

Li Y, Cao Y, Wang J, Fu S, Cheng J, Ma L, Zhang Q, Guo W, Kan X, Liu J

Journal of cellular physiology17 Oct 2019Cited by 19 (Europe PMC)

PMID31621904DOI10.1002/jcp.29325PepBankPUB-31621904

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

7 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Efficacy outcome
In bovine mammary epithelial cells, 100 nM Kp-10 promoted cell proliferation.
In plain wordsIn cow mammary cells in the lab, kisspeptin‑10 made the cells multiply more.
Peptide
Kisspeptin-10
Outcome
IncreasebMEC proliferation
Study
cattlen: not reported in source
bovine mammary epithelial cells (bMECs)
Outcome group
Cell proliferation and differentiation · Reproductive and sexual health
Studied dose
100 nMAs given in this study (cattle).
Source sentences
Summary
100 nM Kp-10 promoted the proliferation of the bMECs.
1 context sentence(design, population, supporting numbers)
Summary · context
This study is devoted to studying the effects of kisspeptin-10 (Kp-10), a peptide hormone composed of 10 amino acids, on bovine mammary epithelial cell (bMEC) proliferation and exploring the underlying mechanism of its action. bMECs were treated with various concentrations of Kp-10 (1, 10, 100, and…
Report a problemFND-3162190401
02LabIn vitro (cells)Mechanism
In bovine mammary epithelial cells, Kp-10 promoted the cell cycle transition from G1 to the S and G2 phases.
In plain wordsIn cow mammary cells in the lab, kisspeptin‑10 pushed cells forward through the cell division cycle.
Peptide
Kisspeptin-10
Outcome
IncreaseCell cycle transition from G1 to S and G2 phases
Study
cattlen: not reported in source
bovine mammary epithelial cells (bMECs)
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Kp-10 promoted the cell cycle transition from G1 to the S and G2 phases
1 context sentence(design, population, supporting numbers)
Summary · context
This study is devoted to studying the effects of kisspeptin-10 (Kp-10), a peptide hormone composed of 10 amino acids, on bovine mammary epithelial cell (bMEC) proliferation and exploring the underlying mechanism of its action. bMECs were treated with various concentrations of Kp-10 (1, 10, 100, and…
Report a problemFND-3162190402
03LabIn vitro (cells)Mechanism
In bovine mammary epithelial cells, Kp-10 increased the protein level of Cyclin D1.
In plain wordsIn cow mammary cells in the lab, kisspeptin‑10 raised levels of Cyclin D1, a protein that drives cell division.
Peptide
Kisspeptin-10
Outcome
IncreaseCyclin D1 protein level
Study
cattlen: not reported in source
bovine mammary epithelial cells (bMECs)
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
increased the protein levels of Cyclin D1 and Cyclin D3, and reduced the expression levels of the p21 gene.
1 context sentence(design, population, supporting numbers)
Summary · context
This study is devoted to studying the effects of kisspeptin-10 (Kp-10), a peptide hormone composed of 10 amino acids, on bovine mammary epithelial cell (bMEC) proliferation and exploring the underlying mechanism of its action. bMECs were treated with various concentrations of Kp-10 (1, 10, 100, and…
Report a problemFND-3162190403
04LabIn vitro (cells)Mechanism
In bovine mammary epithelial cells, Kp-10 increased the protein level of Cyclin D3.
In plain wordsIn cow mammary cells in the lab, kisspeptin‑10 raised levels of Cyclin D3, a protein that drives cell division.
Peptide
Kisspeptin-10
Outcome
IncreaseCyclin D3 protein level
Study
cattlen: not reported in source
bovine mammary epithelial cells (bMECs)
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
increased the protein levels of Cyclin D1 and Cyclin D3, and reduced the expression levels of the p21 gene.
1 context sentence(design, population, supporting numbers)
Summary · context
This study is devoted to studying the effects of kisspeptin-10 (Kp-10), a peptide hormone composed of 10 amino acids, on bovine mammary epithelial cell (bMEC) proliferation and exploring the underlying mechanism of its action. bMECs were treated with various concentrations of Kp-10 (1, 10, 100, and…
Report a problemFND-3162190404
05LabIn vitro (cells)Mechanism
In bovine mammary epithelial cells, Kp-10 reduced the expression of the p21 gene.
In plain wordsIn cow mammary cells in the lab, kisspeptin‑10 lowered activity of the p21 gene, a brake on cell division.
Peptide
Kisspeptin-10
Outcome
Decreasep21 gene expression
Study
cattlen: not reported in source
bovine mammary epithelial cells (bMECs)
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
reduced the expression levels of the p21 gene.
1 context sentence(design, population, supporting numbers)
Summary · context
This study is devoted to studying the effects of kisspeptin-10 (Kp-10), a peptide hormone composed of 10 amino acids, on bovine mammary epithelial cell (bMEC) proliferation and exploring the underlying mechanism of its action. bMECs were treated with various concentrations of Kp-10 (1, 10, 100, and…
Report a problemFND-3162190405
06LabIn vitro (cells)Mechanism
In bovine mammary epithelial cells, Kp-10 decreased the complexes formed by Rb and E2F1.
In plain wordsIn cow mammary cells in the lab, kisspeptin‑10 reduced complexes of Rb and E2F1, proteins that control cell division.
Peptide
Kisspeptin-10
Outcome
DecreaseRb and E2F1 complexes
Study
cattlen: not reported in source
bovine mammary epithelial cells (bMECs)
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Kp-10 decreased the complexes formed by Rb and E2F1 and increased the expression levels of the E2F1 target genes.
1 context sentence(design, population, supporting numbers)
Summary · context
This study is devoted to studying the effects of kisspeptin-10 (Kp-10), a peptide hormone composed of 10 amino acids, on bovine mammary epithelial cell (bMEC) proliferation and exploring the underlying mechanism of its action. bMECs were treated with various concentrations of Kp-10 (1, 10, 100, and…
Report a problemFND-3162190407
07LabIn vitro (cells)Mechanism
In bovine mammary epithelial cells, Kp-10 increased the expression of E2F1 target genes.
In plain wordsIn cow mammary cells in the lab, kisspeptin‑10 raised activity of genes switched on by E2F1.
Peptide
Kisspeptin-10
Outcome
IncreaseE2F1 target gene expression
Study
cattlen: not reported in source
bovine mammary epithelial cells (bMECs)
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
increased the expression levels of the E2F1 target genes.
1 context sentence(design, population, supporting numbers)
Summary · context
This study is devoted to studying the effects of kisspeptin-10 (Kp-10), a peptide hormone composed of 10 amino acids, on bovine mammary epithelial cell (bMEC) proliferation and exploring the underlying mechanism of its action. bMECs were treated with various concentrations of Kp-10 (1, 10, 100, and…
Report a problemFND-3162190408

Studies that did not test the peptide alone1

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

08LabNot a test of Kisspeptin-10 aloneIn vitro (cells)Mechanism
In bovine mammary epithelial cells, inhibition of GPR54, AKT, mTOR and ERK1/2 reduced the proliferation induced by Kp-10.
In plain wordsIn cow mammary cells in the lab, blocking the kisspeptin receptor or its signalling proteins reduced the cell growth caused by kisspeptin‑10.
Peptide
Kisspeptin-10
Outcome
DecreaseInhibition of GPR54, AKT, mTOR and ERK1/2 on Kp-10-induced proliferation
Study
cattlen: not reported in source
bovine mammary epithelial cells (bMECs)
Comparator
Kp-10 alone
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Source sentences
Summary
This study also showed that inhibition of G protein-coupled receptor 54 (GPR54), AKT, mTOR, and ERK1/2 reduced the proliferation of the bMECs that had been induced by Kp-10.
1 context sentence(design, population, supporting numbers)
Summary · context
This study is devoted to studying the effects of kisspeptin-10 (Kp-10), a peptide hormone composed of 10 amino acids, on bovine mammary epithelial cell (bMEC) proliferation and exploring the underlying mechanism of its action. bMECs were treated with various concentrations of Kp-10 (1, 10, 100, and…
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-3162190406

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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