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Study · Animal study (in vivo) · rat · 2019

8 results

The effects of l-Carnosine on development of metabolic syndrome in rats.

Al-Sawalha NA, Alshogran OY, Awawdeh MS, Almomani BA

Life sciences11 Oct 2019Cited by 24 (Europe PMC)

PMID31610198 (opens in a new tab)DOI10.1016/j.lfs.2019.116905 (opens in a new tab)PepBankPUB-31610198
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with metabolic syndrome, l‑carnosine significantly reduced abdominal obesity compared with the same diet without l‑carnosine.

    In plain wordsIn rats with metabolic syndrome, l‑carnosine reduced abdominal obesity compared with the same diet without l‑carnosine.

    Peptide
    L-carnosine
    Outcome
    DecreaseAbdominal obesity
    Study

    ratn: not reported in source

    Male Wistar rats with high-fat high-carbohydrate diet-induced metabolic syndrome
    Comparator
    High-fat high-carbohydrate diet without l-carnosine
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · 16 weeksAs given in this study (rat).

    Source sentences

    Summary
    l-Carnosine supplementation to MetS rats significantly reduced abdominal obesity, blood pressure and glucose, and normalized total cholesterol and low density lipoprotein cholesterol levels (P < 0.05).
    1 context sentence
    Summary · context
    Male Wistar rats were randomly assigned to receive either; conventional diet (control), high-fat high-carbohydrate diet (HFHCD), l-carnosine and conventional diet (L-Car), or l-carnosine and high-fat high-carbohydrate diet (HFHCD and L-Car) for 16 weeks.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with metabolic syndrome, l‑carnosine significantly reduced systolic blood pressure compared with the same diet without l‑carnosine.

    In plain wordsIn rats with metabolic syndrome, l‑carnosine reduced blood pressure compared with the same diet without l‑carnosine.

    Peptide
    L-carnosine
    Outcome
    DecreaseSystolic blood pressure
    Study

    ratn: not reported in source

    Male Wistar rats with high-fat high-carbohydrate diet-induced metabolic syndrome
    Comparator
    High-fat high-carbohydrate diet without l-carnosine
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    Dose not stated · 16 weeksAs given in this study (rat).

    Source sentences

    Summary
    l-Carnosine supplementation to MetS rats significantly reduced abdominal obesity, blood pressure and glucose, and normalized total cholesterol and low density lipoprotein cholesterol levels (P < 0.05).
    1 context sentence
    Summary · context
    Male Wistar rats were randomly assigned to receive either; conventional diet (control), high-fat high-carbohydrate diet (HFHCD), l-carnosine and conventional diet (L-Car), or l-carnosine and high-fat high-carbohydrate diet (HFHCD and L-Car) for 16 weeks.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with metabolic syndrome, l‑carnosine significantly reduced glucose compared with the same diet without l‑carnosine.

    In plain wordsIn rats with metabolic syndrome, l‑carnosine reduced glucose compared with the same diet without l‑carnosine.

    Peptide
    L-carnosine
    Outcome
    DecreaseGlucose
    Study

    ratn: not reported in source

    Male Wistar rats with high-fat high-carbohydrate diet-induced metabolic syndrome
    Comparator
    High-fat high-carbohydrate diet without l-carnosine
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · 16 weeksAs given in this study (rat).

    Source sentences

    Summary
    l-Carnosine supplementation to MetS rats significantly reduced abdominal obesity, blood pressure and glucose, and normalized total cholesterol and low density lipoprotein cholesterol levels (P < 0.05).
    1 context sentence
    Summary · context
    Male Wistar rats were randomly assigned to receive either; conventional diet (control), high-fat high-carbohydrate diet (HFHCD), l-carnosine and conventional diet (L-Car), or l-carnosine and high-fat high-carbohydrate diet (HFHCD and L-Car) for 16 weeks.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with metabolic syndrome, l‑carnosine normalized total cholesterol compared with the same diet without l‑carnosine.

    In plain wordsIn rats with metabolic syndrome, l‑carnosine normalized total cholesterol compared with the same diet without l‑carnosine.

    Peptide
    L-carnosine
    Outcome
    Direction not reportedTotal cholesterol
    Study

    ratn: not reported in source

    Male Wistar rats with high-fat high-carbohydrate diet-induced metabolic syndrome
    Comparator
    High-fat high-carbohydrate diet without l-carnosine
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    Dose not stated · 16 weeksAs given in this study (rat).

    Source sentences

    Summary
    l-Carnosine supplementation to MetS rats significantly reduced abdominal obesity, blood pressure and glucose, and normalized total cholesterol and low density lipoprotein cholesterol levels (P < 0.05).
    1 context sentence
    Summary · context
    Male Wistar rats were randomly assigned to receive either; conventional diet (control), high-fat high-carbohydrate diet (HFHCD), l-carnosine and conventional diet (L-Car), or l-carnosine and high-fat high-carbohydrate diet (HFHCD and L-Car) for 16 weeks.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with metabolic syndrome, l‑carnosine normalized low density lipoprotein cholesterol compared with the same diet without l‑carnosine.

    In plain wordsIn rats with metabolic syndrome, l‑carnosine normalized low density lipoprotein cholesterol compared with the same diet without l‑carnosine.

    Peptide
    L-carnosine
    Outcome
    Direction not reportedLow density lipoprotein cholesterol
    Study

    ratn: not reported in source

    Male Wistar rats with high-fat high-carbohydrate diet-induced metabolic syndrome
    Comparator
    High-fat high-carbohydrate diet without l-carnosine
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    Dose not stated · 16 weeksAs given in this study (rat).

    Source sentences

    Summary
    l-Carnosine supplementation to MetS rats significantly reduced abdominal obesity, blood pressure and glucose, and normalized total cholesterol and low density lipoprotein cholesterol levels (P < 0.05).
    1 context sentence
    Summary · context
    Male Wistar rats were randomly assigned to receive either; conventional diet (control), high-fat high-carbohydrate diet (HFHCD), l-carnosine and conventional diet (L-Car), or l-carnosine and high-fat high-carbohydrate diet (HFHCD and L-Car) for 16 weeks.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In the rat dietary study, l‑carnosine did not significantly affect insulin concentrations.

    In plain wordsIn rats, l‑carnosine did not significantly affect insulin concentrations.

    Peptide
    L-carnosine
    Outcome
    No significant changeInsulin concentration
    Study

    ratn: not reported in source

    Male Wistar rats in the dietary study
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · 16 weeksAs given in this study (rat).

    Source sentences

    Summary
    Insulin, leptin and adiponectin concentrations were not affected by l-Carnosine (P > 0.05).
    1 context sentence
    Summary · context
    Male Wistar rats were randomly assigned to receive either; conventional diet (control), high-fat high-carbohydrate diet (HFHCD), l-carnosine and conventional diet (L-Car), or l-carnosine and high-fat high-carbohydrate diet (HFHCD and L-Car) for 16 weeks.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In the rat dietary study, l‑carnosine did not significantly affect leptin concentrations.

    In plain wordsIn rats, l‑carnosine did not significantly affect leptin concentrations.

    Peptide
    L-carnosine
    Outcome
    No significant changeLeptin concentration
    Study

    ratn: not reported in source

    Male Wistar rats in the dietary study
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · 16 weeksAs given in this study (rat).

    Source sentences

    Summary
    Insulin, leptin and adiponectin concentrations were not affected by l-Carnosine (P > 0.05).
    1 context sentence
    Summary · context
    Male Wistar rats were randomly assigned to receive either; conventional diet (control), high-fat high-carbohydrate diet (HFHCD), l-carnosine and conventional diet (L-Car), or l-carnosine and high-fat high-carbohydrate diet (HFHCD and L-Car) for 16 weeks.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In the rat dietary study, l‑carnosine did not significantly affect adiponectin concentrations.

    In plain wordsIn rats, l‑carnosine did not significantly affect adiponectin concentrations.

    Peptide
    L-carnosine
    Outcome
    No significant changeAdiponectin concentration
    Study

    ratn: not reported in source

    Male Wistar rats in the dietary study
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · 16 weeksAs given in this study (rat).

    Source sentences

    Summary
    Insulin, leptin and adiponectin concentrations were not affected by l-Carnosine (P > 0.05).
    1 context sentence
    Summary · context
    Male Wistar rats were randomly assigned to receive either; conventional diet (control), high-fat high-carbohydrate diet (HFHCD), l-carnosine and conventional diet (L-Car), or l-carnosine and high-fat high-carbohydrate diet (HFHCD and L-Car) for 16 weeks.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

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