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Study · Animal study (in vivo) · mouse · 2019

6 results

MK0677, a Ghrelin Mimetic, Improves Neurogenesis but Fails to Prevent Hippocampal Lesions in a Mouse Model of Alzheimer's Disease Pathology.

Tian J, Wang T, Wang Q, Guo L, Du H

Journal of Alzheimer's disease : JAD1 Jan 2019Cited by 16 (Europe PMC)

PMID31594237 (opens in a new tab)PMCIDPMC7153492 (opens in a new tab)DOI10.3233/jad-190779 (opens in a new tab)PepBankPUB-31594237
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In 5xFAD mice, MK0677 promoted hippocampal neurogenesis.

    In plain wordsIn mice with an Alzheimer's disease model, MK0677 increased hippocampal formation of neurons.

    Peptide
    MK-677 (ibutamoren)
    Outcome
    IncreaseHippocampal neurogenesis
    Study

    mousen: not reported in source

    5xFAD mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We found that MK0677 fostered hippocampal neurogenesis in 5xFAD mice but observed little preventive function with regards to the development of hippocampal amyloid-β (Aβ) deposition, synaptic loss, microglial activation, or cognitive impairment.
    1 context sentence
    Summary · context
    In this study, we treated a transgenic mouse model of AD-like amyloidosis (5xFAD mice) at the asymptomatic stage with MK0677, a potent ghrelin mimetic.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In 5xFAD mice, MK0677 showed little preventive effect on hippocampal Aβ deposition.

    In plain wordsIn mice with an Alzheimer's disease model, MK0677 had little preventive effect on hippocampal amyloid deposits.

    Peptide
    MK-677 (ibutamoren)
    Outcome
    No significant changeAmyloid-β deposition
    Study

    mousen: not reported in source

    5xFAD mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We found that MK0677 fostered hippocampal neurogenesis in 5xFAD mice but observed little preventive function with regards to the development of hippocampal amyloid-β (Aβ) deposition, synaptic loss, microglial activation, or cognitive impairment.
    1 context sentence
    Summary · context
    In this study, we treated a transgenic mouse model of AD-like amyloidosis (5xFAD mice) at the asymptomatic stage with MK0677, a potent ghrelin mimetic.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In 5xFAD mice, MK0677 showed little preventive effect on synaptic loss.

    In plain wordsIn mice with an Alzheimer's disease model, MK0677 had little preventive effect on synaptic loss.

    Peptide
    MK-677 (ibutamoren)
    Outcome
    No significant changeSynaptic loss
    Study

    mousen: not reported in source

    5xFAD mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We found that MK0677 fostered hippocampal neurogenesis in 5xFAD mice but observed little preventive function with regards to the development of hippocampal amyloid-β (Aβ) deposition, synaptic loss, microglial activation, or cognitive impairment.
    1 context sentence
    Summary · context
    In this study, we treated a transgenic mouse model of AD-like amyloidosis (5xFAD mice) at the asymptomatic stage with MK0677, a potent ghrelin mimetic.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In 5xFAD mice, MK0677 showed little preventive effect on microglial activation.

    In plain wordsIn mice with an Alzheimer's disease model, MK0677 had little preventive effect on microglial activation.

    Peptide
    MK-677 (ibutamoren)
    Outcome
    No significant changeMicroglial activation
    Study

    mousen: not reported in source

    5xFAD mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We found that MK0677 fostered hippocampal neurogenesis in 5xFAD mice but observed little preventive function with regards to the development of hippocampal amyloid-β (Aβ) deposition, synaptic loss, microglial activation, or cognitive impairment.
    1 context sentence
    Summary · context
    In this study, we treated a transgenic mouse model of AD-like amyloidosis (5xFAD mice) at the asymptomatic stage with MK0677, a potent ghrelin mimetic.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In 5xFAD mice, MK0677 showed little preventive effect on cognitive impairment.

    In plain wordsIn mice with an Alzheimer's disease model, MK0677 had little preventive effect on cognitive impairment.

    Peptide
    MK-677 (ibutamoren)
    Outcome
    No significant changeCognitive impairment
    Study

    mousen: not reported in source

    5xFAD mice
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We found that MK0677 fostered hippocampal neurogenesis in 5xFAD mice but observed little preventive function with regards to the development of hippocampal amyloid-β (Aβ) deposition, synaptic loss, microglial activation, or cognitive impairment.
    1 context sentence
    Summary · context
    In this study, we treated a transgenic mouse model of AD-like amyloidosis (5xFAD mice) at the asymptomatic stage with MK0677, a potent ghrelin mimetic.
  6. 06AnimalAnimal study (in vivo)Safety outcome

    In 5xFAD mice, MK0677 at 3 mg/kg significantly increased mortality.

    In plain wordsIn mice with an Alzheimer's disease model, MK0677 at 3 mg/kg increased deaths.

    Peptide
    MK-677 (ibutamoren)
    Outcome
    IncreaseMortality
    Study

    mousen: not reported in source

    5xFAD mice
    Outcome group
    Mortality · Whole body
    Studied dose
    3 mg/kgAs given in this study (mouse).

    Measurements

    Dose
    3 mg/kg
    MK0677

    Source sentences

    Summary
    Furthermore, MK0677 at a dose of 3 mg/kg significantly increased 5xFAD mouse mortality.
    1 context sentence
    Summary · context
    In this study, we treated a transgenic mouse model of AD-like amyloidosis (5xFAD mice) at the asymptomatic stage with MK0677, a potent ghrelin mimetic.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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