Skip to content

Study · In vitro (cells) · 2019

4 results

[Gly14]-Humanin Prevents Lipid Deposition and Endothelial Cell Apoptosis in a Lectin-like Oxidized Low-density Lipoprotein Receptor-1-Dependent Manner.

Ding Y, Feng Y, Zhu W, Zou Y, Xie Y, Wang F, Liu CF, Zhang Y, Liu H

Lipids1 Oct 2019Cited by 10 (Europe PMC)

PMID31574567 (opens in a new tab)DOI10.1002/lipd.12195 (opens in a new tab)PepBankPUB-31574567
Publisher pagePubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In HUVEC, HNG reduced Ox-LDL accumulation.

    In plain wordsIn cells, HNG reduced the buildup of oxidized LDL in blood vessel lining cells.

    Peptide
    Humanin
    Outcome
    DecreaseOx-LDL accumulation in HUVEC
    Study

    humann: not reported in source

    Human umbilical vein endothelial cells (HUVEC)
    Comparator
    Ox-LDL without HNG
    Outcome group
    Lipids · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Flow cytometry and tissue total cholesterol assays showed that HNG reduced Ox-LDL accumulation in HUVEC.
    2 context sentences
    Summary · context
    In this study, we investigated the effect of HNG on Ox-LDL accumulation in human umbilical vein endothelial cell (HUVEC) and its underlying mechanisms.
    Summary · context
    HUVEC were preincubated with HNG for 1 h before addition of Ox-LDL.
  2. 02LabIn vitro (cells)Efficacy outcome

    In HUVEC, HNG inhibited Ox-LDL-induced apoptosis.

    In plain wordsIn cells, HNG reduced oxidized LDL-induced cell death in blood vessel lining cells.

    Peptide
    Humanin
    Outcome
    DecreaseOx-LDL-induced apoptosis of HUVEC
    Study

    humann: not reported in source

    Human umbilical vein endothelial cells (HUVEC)
    Comparator
    Ox-LDL without HNG
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, HNG inhibited Ox-LDL-induced apoptosis of HUVEC.
    2 context sentences
    Summary · context
    In this study, we investigated the effect of HNG on Ox-LDL accumulation in human umbilical vein endothelial cell (HUVEC) and its underlying mechanisms.
    Summary · context
    HUVEC were preincubated with HNG for 1 h before addition of Ox-LDL.
  3. 03LabIn vitro (cells)Mechanism

    In HUVEC, HNG reduced LOX-1 protein content.

    In plain wordsIn cells, HNG lowered the amount of the LOX-1 receptor protein.

    Peptide
    Humanin
    Outcome
    DecreaseLOX-1 protein content
    Study

    humann: not reported in source

    Human umbilical vein endothelial cells (HUVEC)
    Comparator
    Ox-LDL without HNG
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Western blot results showed that HNG reduced LOX-1 protein content.
    2 context sentences
    Summary · context
    In this study, we investigated the effect of HNG on Ox-LDL accumulation in human umbilical vein endothelial cell (HUVEC) and its underlying mechanisms.
    Summary · context
    HUVEC were preincubated with HNG for 1 h before addition of Ox-LDL.
  4. 04LabIn vitro (cells)Mechanism

    In HUVEC with LOX-1 knocked down or inhibited, the effect of HNG on Ox-LDL aggregation and apoptosis disappeared.

    In plain wordsIn cells without working LOX-1, HNG no longer reduced oxidized LDL buildup or cell death.

    Peptide
    Humanin
    Outcome
    No significant changeHNG effect on Ox-LDL aggregation and apoptosis when LOX-1 is knocked down or inhibited
    Study

    humann: not reported in source

    Human umbilical vein endothelial cells (HUVEC)
    Comparator
    HNG with intact LOX-1
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, when LOX-1 was knocked down or inhibited, the effect of HNG in reducing Ox-LDL aggregation and apoptosis in HUVEC disappeared.
    2 context sentences
    Summary · context
    In this study, we investigated the effect of HNG on Ox-LDL accumulation in human umbilical vein endothelial cell (HUVEC) and its underlying mechanisms.
    Summary · context
    HUVEC were preincubated with HNG for 1 h before addition of Ox-LDL.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.