Effects of thymosin β4 on neuronal apoptosis in a rat model of cerebral ischemia‑reperfusion injury.

Zhang Z, Liu S, Huang S

Molecular medicine reports13 Sept 2019Cited by 7 (Europe PMC)

PMID31545437PMCIDPMC6797993DOI10.3892/mmr.2019.10683PepBankPUB-31545437

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with MCAO ischemia/reperfusion injury, the Longa score was lower in the Tβ4 group than in the I/R group.
In plain wordsIn rats with induced stroke injury, thymosin beta‑4 lowered the neurological deficit score compared with untreated injured rats.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseZea-Longa neurological deficit score
Study
ratn = 16
Middle cerebral artery occlusion ischemia/reperfusion (MCAO I/R)
Comparator
I/R group
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
However, the Longa score and neuronal apoptosis were lower in the Tβ4 group compared to the I/R group.
2 context sentences(design, population, supporting numbers)
Summary · context
Forty‑eight adult male Sprague‑Dawley rats were randomly divided into three groups (n=16 per group): A sham control group, an ischemia/reperfusion group (I/R group), and a Tβ4 group.
Summary · context
The focal cerebral I/R model was established by blocking the right MCA for 2 h, followed by reperfusion for 24 h.
Report a problemFND-3154543701
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with MCAO ischemia/reperfusion injury, neuronal apoptosis was lower in the Tβ4 group than in the I/R group.
In plain wordsIn rats with induced stroke injury, thymosin beta‑4 reduced nerve cell death compared with untreated injured rats.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseNeuronal apoptosis
Study
ratn = 16
Middle cerebral artery occlusion ischemia/reperfusion (MCAO I/R)
Comparator
I/R group
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
However, the Longa score and neuronal apoptosis were lower in the Tβ4 group compared to the I/R group.
2 context sentences(design, population, supporting numbers)
Summary · context
Forty‑eight adult male Sprague‑Dawley rats were randomly divided into three groups (n=16 per group): A sham control group, an ischemia/reperfusion group (I/R group), and a Tβ4 group.
Summary · context
The focal cerebral I/R model was established by blocking the right MCA for 2 h, followed by reperfusion for 24 h.
Report a problemFND-3154543702
03AnimalAnimal study (in vivo)Mechanism
In rats with MCAO ischemia/reperfusion injury, GRP78 expression was significantly increased in the Tβ4 group compared with the I/R group.
In plain wordsIn rats with induced stroke injury, thymosin beta‑4 raised the level of the protein GRP78 compared with untreated injured rats.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseGRP78 expression
Study
ratn = 16
Middle cerebral artery occlusion ischemia/reperfusion (MCAO I/R)
Comparator
I/R group
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
The expression of GRP78 was significantly increased, whereas that of CHOP and CASP12 was significantly decreased in the Tβ4 group compared to the I/R group.
2 context sentences(design, population, supporting numbers)
Summary · context
Forty‑eight adult male Sprague‑Dawley rats were randomly divided into three groups (n=16 per group): A sham control group, an ischemia/reperfusion group (I/R group), and a Tβ4 group.
Summary · context
The focal cerebral I/R model was established by blocking the right MCA for 2 h, followed by reperfusion for 24 h.
Report a problemFND-3154543703
04AnimalAnimal study (in vivo)Mechanism
In rats with MCAO ischemia/reperfusion injury, CHOP expression was significantly decreased in the Tβ4 group compared with the I/R group.
In plain wordsIn rats with induced stroke injury, thymosin beta‑4 lowered the level of the protein CHOP compared with untreated injured rats.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseCHOP expression
Study
ratn = 16
Middle cerebral artery occlusion ischemia/reperfusion (MCAO I/R)
Comparator
I/R group
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
The expression of GRP78 was significantly increased, whereas that of CHOP and CASP12 was significantly decreased in the Tβ4 group compared to the I/R group.
2 context sentences(design, population, supporting numbers)
Summary · context
Forty‑eight adult male Sprague‑Dawley rats were randomly divided into three groups (n=16 per group): A sham control group, an ischemia/reperfusion group (I/R group), and a Tβ4 group.
Summary · context
The focal cerebral I/R model was established by blocking the right MCA for 2 h, followed by reperfusion for 24 h.
Report a problemFND-3154543704
05AnimalAnimal study (in vivo)Mechanism
In rats with MCAO ischemia/reperfusion injury, caspase-12 expression was significantly decreased in the Tβ4 group compared with the I/R group.
In plain wordsIn rats with induced stroke injury, thymosin beta‑4 lowered the level of the protein caspase-12 compared with untreated injured rats.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseCaspase-12 expression
Study
ratn = 16
Middle cerebral artery occlusion ischemia/reperfusion (MCAO I/R)
Comparator
I/R group
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
The expression of GRP78 was significantly increased, whereas that of CHOP and CASP12 was significantly decreased in the Tβ4 group compared to the I/R group.
2 context sentences(design, population, supporting numbers)
Summary · context
Forty‑eight adult male Sprague‑Dawley rats were randomly divided into three groups (n=16 per group): A sham control group, an ischemia/reperfusion group (I/R group), and a Tβ4 group.
Summary · context
The focal cerebral I/R model was established by blocking the right MCA for 2 h, followed by reperfusion for 24 h.
Report a problemFND-3154543705

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

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