Skip to content

Study · Animal study (in vivo) · papio hamadryas · 2019

10 results

Exenatide regulates pancreatic islet integrity and insulin sensitivity in the nonhuman primate baboon Papio hamadryas.

Fiorentino TV, Casiraghi F, Davalli AM, Finzi G, La Rosa S, Higgins PB, Abrahamian GA, Marando A, Sessa F, Perego C, Guardado-Mendoza R, Kamath S and 16 more

Show all authors

Ricotti A, Fiorina P, Daniele G, Paez AM, Andreozzi F, Bastarrachea RA, Comuzzie AG, Gastaldelli A, Chavez AO, Di Cairano ES, Frost P, Luzi L, Dick EJ, Halff GA, DeFronzo RA, Folli F

JCI insight17 Oct 2019Cited by 20 (Europe PMC)

PMID31536476 (opens in a new tab)PMCIDPMC6824445 (opens in a new tab)DOI10.1172/jci.insight.93091 (opens in a new tab)PepBankPUB-31536476
Source linkPubMedAsk about this study
Jump to 10 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In baboons, exenatide increased β cell relative volume versus saline.

    In plain wordsIn baboons, exenatide increased β cell relative volume versus saline.

    Peptide
    Exenatide (exendin-4)
    Outcome
    Increaseβ cell relative volume
    Study

    Papio hamadryasn = 24

    Nondiabetic baboons after partial pancreatectomy
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · intravenous · 13 weeksAs given in this study (Papio hamadryas).

    Source sentences

    Summary
    β, α, and δ cell relative volumes in exenatide-treated baboons were significantly increased compared with saline-treated controls, primarily as the result of increased islet cell replication.
    2 context sentences
    Summary · context
    Herein, we examined the effects of chronic intravenous exenatide infusion on insulin sensitivity, β cell and α cell function and relative volumes, and islet cell apoptosis and replication in nondiabetic nonhuman primates (baboons).
    Summary · context
    After HC/A, baboons underwent a partial pancreatectomy (tail removal) and received a continuous exenatide (n = 12) or saline (n = 12) infusion for 13 weeks.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In baboons, exenatide increased α cell relative volume versus saline.

    In plain wordsIn baboons, exenatide increased α cell relative volume versus saline.

    Peptide
    Exenatide (exendin-4)
    Outcome
    Increaseα cell relative volume
    Study

    Papio hamadryasn = 24

    Nondiabetic baboons after partial pancreatectomy
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · intravenous · 13 weeksAs given in this study (Papio hamadryas).

    Source sentences

    Summary
    β, α, and δ cell relative volumes in exenatide-treated baboons were significantly increased compared with saline-treated controls, primarily as the result of increased islet cell replication.
    2 context sentences
    Summary · context
    Herein, we examined the effects of chronic intravenous exenatide infusion on insulin sensitivity, β cell and α cell function and relative volumes, and islet cell apoptosis and replication in nondiabetic nonhuman primates (baboons).
    Summary · context
    After HC/A, baboons underwent a partial pancreatectomy (tail removal) and received a continuous exenatide (n = 12) or saline (n = 12) infusion for 13 weeks.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In baboons, exenatide increased δ cell relative volume versus saline.

    In plain wordsIn baboons, exenatide increased δ cell relative volume versus saline.

    Peptide
    Exenatide (exendin-4)
    Outcome
    Increaseδ cell relative volume
    Study

    Papio hamadryasn = 24

    Nondiabetic baboons after partial pancreatectomy
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · intravenous · 13 weeksAs given in this study (Papio hamadryas).

    Source sentences

    Summary
    β, α, and δ cell relative volumes in exenatide-treated baboons were significantly increased compared with saline-treated controls, primarily as the result of increased islet cell replication.
    2 context sentences
    Summary · context
    Herein, we examined the effects of chronic intravenous exenatide infusion on insulin sensitivity, β cell and α cell function and relative volumes, and islet cell apoptosis and replication in nondiabetic nonhuman primates (baboons).
    Summary · context
    After HC/A, baboons underwent a partial pancreatectomy (tail removal) and received a continuous exenatide (n = 12) or saline (n = 12) infusion for 13 weeks.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In baboons, increased islet cell replication primarily explained larger islet cell volumes with exenatide versus saline.

    In plain wordsIn baboons, increased islet cell replication primarily explained larger islet cell volumes with exenatide versus saline.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseIslet cell replication
    Study

    Papio hamadryasn = 24

    Nondiabetic baboons after partial pancreatectomy
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · intravenous · 13 weeksAs given in this study (Papio hamadryas).

    Source sentences

    Summary
    β, α, and δ cell relative volumes in exenatide-treated baboons were significantly increased compared with saline-treated controls, primarily as the result of increased islet cell replication.
    2 context sentences
    Summary · context
    Herein, we examined the effects of chronic intravenous exenatide infusion on insulin sensitivity, β cell and α cell function and relative volumes, and islet cell apoptosis and replication in nondiabetic nonhuman primates (baboons).
    Summary · context
    After HC/A, baboons underwent a partial pancreatectomy (tail removal) and received a continuous exenatide (n = 12) or saline (n = 12) infusion for 13 weeks.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In baboons, islet cellular stress features were absent with exenatide but present with saline.

    In plain wordsIn baboons, islet cellular stress features were absent with exenatide but present with saline.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseIslet cellular stress
    Study

    Papio hamadryasn = 24

    Nondiabetic baboons after partial pancreatectomy
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · intravenous · 13 weeksAs given in this study (Papio hamadryas).

    Source sentences

    Summary
    Features of cellular stress and secretory dysfunction were present in islets of saline-treated baboons and absent in islets of exenatide-treated baboons.
    2 context sentences
    Summary · context
    Herein, we examined the effects of chronic intravenous exenatide infusion on insulin sensitivity, β cell and α cell function and relative volumes, and islet cell apoptosis and replication in nondiabetic nonhuman primates (baboons).
    Summary · context
    After HC/A, baboons underwent a partial pancreatectomy (tail removal) and received a continuous exenatide (n = 12) or saline (n = 12) infusion for 13 weeks.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In baboons, islet secretory dysfunction features were absent with exenatide but present with saline.

    In plain wordsIn baboons, islet secretory dysfunction features were absent with exenatide but present with saline.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseIslet secretory dysfunction
    Study

    Papio hamadryasn = 24

    Nondiabetic baboons after partial pancreatectomy
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · intravenous · 13 weeksAs given in this study (Papio hamadryas).

    Source sentences

    Summary
    Features of cellular stress and secretory dysfunction were present in islets of saline-treated baboons and absent in islets of exenatide-treated baboons.
    2 context sentences
    Summary · context
    Herein, we examined the effects of chronic intravenous exenatide infusion on insulin sensitivity, β cell and α cell function and relative volumes, and islet cell apoptosis and replication in nondiabetic nonhuman primates (baboons).
    Summary · context
    After HC/A, baboons underwent a partial pancreatectomy (tail removal) and received a continuous exenatide (n = 12) or saline (n = 12) infusion for 13 weeks.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In baboons, insulin sensitivity increased after exenatide treatment.

    In plain wordsIn baboons, insulin sensitivity increased after exenatide treatment.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseInsulin sensitivity
    Study

    Papio hamadryasn = 12

    Nondiabetic baboons after partial pancreatectomy
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · intravenous · 13 weeksAs given in this study (Papio hamadryas).

    Source sentences

    Summary
    Insulin sensitivity increased dramatically after exenatide treatment and was accompanied by a decrease in insulin and C-peptide secretion, while the insulin secretion/insulin resistance (disposition) index increased by about 2-fold.
    2 context sentences
    Summary · context
    Herein, we examined the effects of chronic intravenous exenatide infusion on insulin sensitivity, β cell and α cell function and relative volumes, and islet cell apoptosis and replication in nondiabetic nonhuman primates (baboons).
    Summary · context
    After HC/A, baboons underwent a partial pancreatectomy (tail removal) and received a continuous exenatide (n = 12) or saline (n = 12) infusion for 13 weeks.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In baboons, insulin secretion decreased after exenatide treatment.

    In plain wordsIn baboons, insulin secretion decreased after exenatide treatment.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseInsulin secretion
    Study

    Papio hamadryasn = 12

    Nondiabetic baboons after partial pancreatectomy
    Outcome group
    Glycemic control · Endocrine and hormones
    Studied dose
    Dose not stated · intravenous · 13 weeksAs given in this study (Papio hamadryas).

    Source sentences

    Summary
    Insulin sensitivity increased dramatically after exenatide treatment and was accompanied by a decrease in insulin and C-peptide secretion, while the insulin secretion/insulin resistance (disposition) index increased by about 2-fold.
    2 context sentences
    Summary · context
    Herein, we examined the effects of chronic intravenous exenatide infusion on insulin sensitivity, β cell and α cell function and relative volumes, and islet cell apoptosis and replication in nondiabetic nonhuman primates (baboons).
    Summary · context
    After HC/A, baboons underwent a partial pancreatectomy (tail removal) and received a continuous exenatide (n = 12) or saline (n = 12) infusion for 13 weeks.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In baboons, C-peptide secretion decreased after exenatide treatment.

    In plain wordsIn baboons, C-peptide secretion decreased after exenatide treatment.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseC-peptide secretion
    Study

    Papio hamadryasn = 12

    Nondiabetic baboons after partial pancreatectomy
    Outcome group
    Glycemic control · Endocrine and hormones
    Studied dose
    Dose not stated · intravenous · 13 weeksAs given in this study (Papio hamadryas).

    Source sentences

    Summary
    Insulin sensitivity increased dramatically after exenatide treatment and was accompanied by a decrease in insulin and C-peptide secretion, while the insulin secretion/insulin resistance (disposition) index increased by about 2-fold.
    2 context sentences
    Summary · context
    Herein, we examined the effects of chronic intravenous exenatide infusion on insulin sensitivity, β cell and α cell function and relative volumes, and islet cell apoptosis and replication in nondiabetic nonhuman primates (baboons).
    Summary · context
    After HC/A, baboons underwent a partial pancreatectomy (tail removal) and received a continuous exenatide (n = 12) or saline (n = 12) infusion for 13 weeks.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In baboons, the disposition index increased about 2-fold after exenatide treatment.

    In plain wordsIn baboons, the disposition index increased about 2-fold after exenatide treatment.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseDisposition index
    Study

    Papio hamadryasn = 12

    Nondiabetic baboons after partial pancreatectomy
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · intravenous · 13 weeksAs given in this study (Papio hamadryas).

    Measurements

    Disposition index increase
    ≈ 2 fold
    after exenatide

    Source sentences

    Summary
    Insulin sensitivity increased dramatically after exenatide treatment and was accompanied by a decrease in insulin and C-peptide secretion, while the insulin secretion/insulin resistance (disposition) index increased by about 2-fold.
    2 context sentences
    Summary · context
    Herein, we examined the effects of chronic intravenous exenatide infusion on insulin sensitivity, β cell and α cell function and relative volumes, and islet cell apoptosis and replication in nondiabetic nonhuman primates (baboons).
    Summary · context
    After HC/A, baboons underwent a partial pancreatectomy (tail removal) and received a continuous exenatide (n = 12) or saline (n = 12) infusion for 13 weeks.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.