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Study · Animal study (in vivo) · cattle · 2020

9 results

Kisspeptin induces ovulation in heifers under low plasma progesterone concentrations.

Leonardi CEP, Dias FCF, Adams GP, Araujo ER, Singh J

Theriogenology4 Sept 2019Cited by 12 (Europe PMC)

PMID31494459 (opens in a new tab)DOI10.1016/j.theriogenology.2019.08.033 (opens in a new tab)PepBankPUB-31494459
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In heifers, human kisspeptin‑10 given as multiple intravenous doses over 2 hours gave higher plasma LH than saline in all treatment groups.

    In plain wordsIn heifers, human kisspeptin‑10 given in several doses over 2 hours raised luteinizing hormone more than saline did.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePlasma LH after multiple-dose human kisspeptin-10 (Experiment 2)
    Study

    cattlen = 24

    Heifers with an induced follicular wave and a progesterone device
    Comparator
    Saline
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    45 mg divided into multiple doses · intravenous · 2 hoursAs given in this study (cattle).

    Source sentences

    Summary
    Post-treatment plasma LH concentrations were higher (P < 0.01) in all hKp treatment groups than in the control group.
    1 context sentence
    Summary · context
    In Experiment 2, heifers (n = 6/group) were given 45 mg hKp over a 2 h period divided into multiple iv doses treatments or 2 ml normal saline (control).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In heifers, the ovulation rate after human kisspeptin‑10 (11/18) tended to be higher than after saline (0/6), P = 0.06.

    In plain wordsIn heifers, 11 of 18 ovulated after human kisspeptin‑10 and none of 6 after saline. The difference was not clearly significant.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeOvulation rate after multiple-dose human kisspeptin-10 (Experiment 2)
    Study

    cattlen = 24

    Heifers with an induced follicular wave and a progesterone device
    Comparator
    Saline
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    45 mg divided into multiple doses · intravenous · 2 hoursAs given in this study (cattle).

    Source sentences

    Summary
    The ovulation rate was higher (P = 0.06) after hKp treatments (11/18) than in the control group (0/6).
    1 context sentence
    Summary · context
    In Experiment 2, heifers (n = 6/group) were given 45 mg hKp over a 2 h period divided into multiple iv doses treatments or 2 ml normal saline (control).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In heifers, a single intravenous dose of human kisspeptin‑10 gave higher plasma LH from 15 to 90 minutes than saline.

    In plain wordsIn heifers, one dose of human kisspeptin‑10 raised luteinizing hormone more than saline did.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePlasma LH after single-dose human kisspeptin-10 (Experiment 1)
    Study

    cattlen = 20

    Heifers with an induced follicular wave and a progesterone device
    Comparator
    Saline
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    45 mg · intravenous · single doseAs given in this study (cattle).

    Source sentences

    Summary
    Post-treatment plasma LH concentrations from 15 to 90 min were higher (P < 0.01) in hKp group than in the mKp and control groups.
    1 context sentence
    Summary · context
    In Experiment 1, heifers (n = 10/group) were given single iv dose of 45 mg hKp, 45 mg mKp, or 2 ml normal saline (control).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In heifers, a single intravenous dose of human kisspeptin‑10 gave higher plasma LH from 15 to 90 minutes than murine kisspeptin‑10.

    In plain wordsIn heifers, one dose of human kisspeptin‑10 raised luteinizing hormone more than murine kisspeptin‑10 did.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePlasma LH, human versus murine kisspeptin-10 (Experiment 1)
    Study

    cattlen = 20

    Heifers with an induced follicular wave and a progesterone device
    Comparator
    Murine kisspeptin-10 (mKp)
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    45 mg · intravenous · single doseAs given in this study (cattle).

    Source sentences

    Summary
    Post-treatment plasma LH concentrations from 15 to 90 min were higher (P < 0.01) in hKp group than in the mKp and control groups.
    1 context sentence
    Summary · context
    In Experiment 1, heifers (n = 10/group) were given single iv dose of 45 mg hKp, 45 mg mKp, or 2 ml normal saline (control).
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In heifers, two heifers ovulated after a single dose of human kisspeptin‑10 and none ovulated after saline.

    In plain wordsIn heifers, two ovulated after one dose of human kisspeptin‑10 and none after saline.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseOvulation after single-dose human kisspeptin-10 versus saline (Experiment 1)
    Study

    cattlen = 20

    Heifers with an induced follicular wave and a progesterone device
    Comparator
    Saline
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    45 mg · intravenous · single doseAs given in this study (cattle).

    Source sentences

    Summary
    Two heifers ovulated in hKp group versus none in other groups.
    1 context sentence
    Summary · context
    In Experiment 1, heifers (n = 10/group) were given single iv dose of 45 mg hKp, 45 mg mKp, or 2 ml normal saline (control).
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In heifers, two heifers ovulated after human kisspeptin‑10 and none after murine kisspeptin‑10; human kisspeptin‑10 was more effective at inducing ovulation.

    In plain wordsIn heifers, two ovulated after human kisspeptin‑10 and none after murine kisspeptin‑10.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseOvulation after single-dose human versus murine kisspeptin-10 (Experiment 1)
    Study

    cattlen = 20

    Heifers with an induced follicular wave and a progesterone device
    Comparator
    Murine kisspeptin-10 (mKp)
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    45 mg · intravenous · single doseAs given in this study (cattle).

    Source sentences

    Summary
    Two heifers ovulated in hKp group versus none in other groups.
    2 context sentences
    Summary · context
    In summary, hKp was more effective to induce ovulation than mKp.
    Summary · context
    In Experiment 1, heifers (n = 10/group) were given single iv dose of 45 mg hKp, 45 mg mKp, or 2 ml normal saline (control).
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In heifers under low progesterone, human kisspeptin‑10 given over 2 hours (11/18 ovulated in Experiment 2) induced ovulation at a rate the authors called similar to gonadorelin acetate (5/6 in Experiment 3); the two treatments were in different experiments and were not tested against each other.

    In plain wordsIn heifers, ovulation after human kisspeptin‑10 was reported as similar to that after GnRH, but they were not tested against each other.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeOvulation rate, human kisspeptin-10 versus GnRH treatment
    Study

    cattlen: not reported in source

    Heifers with an induced follicular wave and a progesterone device
    Comparator
    Gonadorelin acetate (GnRH), in a separate experiment
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    45 mg · intravenous · 2 hoursAs given in this study (cattle).

    Source sentences

    Summary
    Human kisspeptin-10 given over a 2 h period induced ovulations at a rate similar to that of GnRH treatment in heifers under a low plasma progesterone state.
    2 context sentences
    Summary · context
    The ovulation rate was higher (P = 0.06) after hKp treatments (11/18) than in the control group (0/6).
    Summary · context
    Plasma LH concentration was higher (P < 0.01) and the ovulation rate was greater (P = 0.01) in the GnRH group (5/6) than mKp groups (1/12).

Studies that did not test the peptide alone2

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

  1. 08AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Efficacy outcome

    In heifers, plasma LH was lower after multiple doses of murine kisspeptin‑10 than after gonadorelin acetate (P < 0.01).

    In plain wordsIn heifers, murine kisspeptin‑10 raised luteinizing hormone less than gonadorelin acetate did.

    Peptide
    Kisspeptin-10
    Outcome
    DecreasePlasma LH, murine kisspeptin-10 versus gonadorelin (Experiment 3)
    Study

    cattlen = 18

    Heifers with an induced follicular wave and a progesterone device
    Comparator
    Gonadorelin acetate
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Plasma LH concentration was higher (P < 0.01) and the ovulation rate was greater (P = 0.01) in the GnRH group (5/6) than mKp groups (1/12).
    1 context sentence
    Summary · context
    In Experiment 3, heifers (n = 6/group) were given 45 mg mKp over a 2 h period divided into multiple iv doses treatments or a single iv dose of gonadorelin acetate (positive control).

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

  2. 09AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Efficacy outcome

    In heifers, the ovulation rate was lower after multiple doses of murine kisspeptin‑10 (1/12) than after gonadorelin acetate (5/6), P = 0.01.

    In plain wordsIn heifers, 1 of 12 ovulated after murine kisspeptin‑10 and 5 of 6 after gonadorelin acetate.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseOvulation rate, murine kisspeptin-10 versus gonadorelin (Experiment 3)
    Study

    cattlen = 18

    Heifers with an induced follicular wave and a progesterone device
    Comparator
    Gonadorelin acetate
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Plasma LH concentration was higher (P < 0.01) and the ovulation rate was greater (P = 0.01) in the GnRH group (5/6) than mKp groups (1/12).
    1 context sentence
    Summary · context
    In Experiment 3, heifers (n = 6/group) were given 45 mg mKp over a 2 h period divided into multiple iv doses treatments or a single iv dose of gonadorelin acetate (positive control).

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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