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Study · Animal study (in vivo) · mouse · 2019

3 results

Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effects.

Kiss T, Giles CB, Tarantini S, Yabluchanskiy A, Balasubramanian P, Gautam T, Csipo T, Nyúl-Tóth Á, Lipecz A, Szabo C, Farkas E, Wren JD, Csiszar A, Ungvari Z

GeroScience28 Aug 2019Cited by 102 (Europe PMC)

PMID31463647 (opens in a new tab)PMCIDPMC6815288 (opens in a new tab)DOI10.1007/s11357-019-00095-x (opens in a new tab)PepBankPUB-31463647
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In aged mice, NMN-associated vascular protection accompanied anti-aging changes in aortic miRNA expression.

    In plain wordsIn aged mice, vascular protection with NMN accompanied changes toward a younger aortic miRNA profile.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Not applicableAortic miRNA expression profile
    Study

    mousen: not reported in source

    Aged mouse aorta
    Comparator
    Untreated young and aged control mice
    Outcome group
    Aging markers · Cardiovascular
    Studied dose
    Dose not stated · 2 weeksAs given in this study (mouse).

    Source sentences

    Summary
    We found that protective effects of NMN treatment on vascular function are associated with anti-aging changes in the miRNA expression profile in the aged mouse aorta.
    1 context sentence
    Summary · context
    To test these hypotheses, aged (24-month-old) mice were treated with NMN for 2 weeks and miRNA signatures in the aortas were compared to those in aortas obtained from untreated young and aged control mice.

Studies that did not test the peptide alone2

In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking NMN (nicotinamide mononucleotide).

  1. 02Computer modelNot a test of NMN (nicotinamide mononucleotide) aloneIn silicoMechanism

    Analysis predicted anti-atherogenic regulatory effects of miRNAs altered by NMN in aged mouse vessels.

    In plain wordsComputer analysis predicted effects against atherosclerosis from miRNA changes after NMN in aged mouse vessels.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Not applicablePredicted anti-atherogenic effects
    Study

    mousen: not reported in source

    Aged mouse aorta
    Outcome group
    Receptor activity and mechanism · Cardiovascular

    Source sentences

    Summary
    The predicted regulatory effects of NMN-induced differentially expressed miRNAs in aged vessels include anti-atherogenic effects and epigenetic rejuvenation.
    1 context sentence
    Summary · context
    To test these hypotheses, aged (24-month-old) mice were treated with NMN for 2 weeks and miRNA signatures in the aortas were compared to those in aortas obtained from untreated young and aged control mice.

    In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).

  2. 03Computer modelNot a test of NMN (nicotinamide mononucleotide) aloneIn silicoMechanism

    Analysis predicted epigenetic rejuvenation from miRNAs altered by NMN in aged mouse vessels.

    In plain wordsComputer analysis predicted younger epigenetic patterns from miRNA changes after NMN in aged mouse vessels.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Not applicablePredicted epigenetic rejuvenation
    Study

    mousen: not reported in source

    Aged mouse aorta
    Outcome group
    Aging markers · Aging and longevity

    Source sentences

    Summary
    The predicted regulatory effects of NMN-induced differentially expressed miRNAs in aged vessels include anti-atherogenic effects and epigenetic rejuvenation.
    1 context sentence
    Summary · context
    To test these hypotheses, aged (24-month-old) mice were treated with NMN for 2 weeks and miRNA signatures in the aortas were compared to those in aortas obtained from untreated young and aged control mice.

    In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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