Comparative study on anorexigenic effect of glucagon-like peptide-1 receptor agonists in rats.

Wen S, Nguyen T, Xiao WZ, Wang CX, Gong M, Jin JL, Zhou LG

Sheng li xue bao : [Acta physiologica Sinica]1 Aug 2019Cited by 3 (Europe PMC)

PMID31440748PepBankPUB-31440748

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

2 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In normal rats, a single intraperitoneal dose of liraglutide significantly influenced food intake, described as an anorexic effect.
In plain wordsIn rats, a single injection of liraglutide reduced how much the animals ate.
Peptide
Liraglutide
Outcome
DecreaseFood intake
Study
ratn = 30
Normal Sprague-Dawley rats
Comparator
Saline
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
200 μg/kg · intraperitoneal · single injectionAs given in this study (rat).
Source sentences
Summary
The results showed that acute pharmacological dosage of GLP-1RA (Liraglutide or Exenatide) could significantly influence food intake.
3 context sentences(design, population, supporting numbers)
Summary · context
the anorexic effect was dissociated with change in blood glucose in normal rats
Summary · context
Thirty normal SD rats were randomly assigned to 3 groups, which were single intraperitoneally injected with Liraglutide (200 μg/kg), Exenatide (10 μg/kg) and saline, respectively.
Summary · context
After injection, the amount of food intake and acute glycemic variation were assessed for comparison.
Report a problemFND-3144074801
02AnimalAnimal study (in vivo)Efficacy outcome
In normal rats, the anorexic effect of liraglutide was dissociated from any change in blood glucose.
In plain wordsIn rats, liraglutide cut food intake without a matching change in blood sugar.
Peptide
Liraglutide
Outcome
No significant changeAcute blood glucose change
Study
ratn = 30
Normal Sprague-Dawley rats
Comparator
Saline
Outcome group
Glycemic control · Metabolic and weight
Studied dose
200 μg/kg · intraperitoneal · single injectionAs given in this study (rat).
Source sentences
Summary
However, glycemic change indicated that the anorexic effect was dissociated with change in blood glucose in normal rats.
2 context sentences(design, population, supporting numbers)
Summary · context
Thirty normal SD rats were randomly assigned to 3 groups, which were single intraperitoneally injected with Liraglutide (200 μg/kg), Exenatide (10 μg/kg) and saline, respectively.
Summary · context
After injection, the amount of food intake and acute glycemic variation were assessed for comparison.
Report a problemFND-3144074802

Studies that did not test the peptide alone2

In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Liraglutide.

03AnimalNot a test of Liraglutide aloneAnimal study (in vivo)Mechanism
In normal rats, c-Fos expression was significantly higher in major nuclei related to food intake in the GLP-1 receptor agonist groups (liraglutide or exenatide, pooled) than in the saline control group.
In plain wordsIn rats, GLP-1 drugs (liraglutide or exenatide, reported together) raised a marker of nerve cell activity in brain areas that control eating, compared with saline.
Peptide
Liraglutide
Outcome
Increasec-Fos expression in food-intake nuclei
Study
ratn = 30
Normal Sprague-Dawley rats
Comparator
Saline
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
c-Fos was expressed significantly higher in major critical nuclei related to food intake in GLP-1RA groups when compared with the control group
2 context sentences(design, population, supporting numbers)
Summary · context
Thirty normal SD rats were randomly assigned to 3 groups, which were single intraperitoneally injected with Liraglutide (200 μg/kg), Exenatide (10 μg/kg) and saline, respectively.
Summary · context
After injection, the amount of food intake and acute glycemic variation were assessed for comparison.
In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.
Report a problemFND-3144074803
04AnimalNot a test of Liraglutide aloneAnimal study (in vivo)Mechanism
In normal rats, c-Fos expression was also found in the spinal cord in the GLP-1 receptor agonist groups (liraglutide or exenatide, pooled).
In plain wordsIn rats, GLP-1 drugs (liraglutide or exenatide, reported together) also switched on a nerve activity marker in the spinal cord.
Peptide
Liraglutide
Outcome
Increasec-Fos expression in spinal cord
Study
ratn = 30
Normal Sprague-Dawley rats
Comparator
Saline
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
its expression was also found in spinal cord.
2 context sentences(design, population, supporting numbers)
Summary · context
Thirty normal SD rats were randomly assigned to 3 groups, which were single intraperitoneally injected with Liraglutide (200 μg/kg), Exenatide (10 μg/kg) and saline, respectively.
Summary · context
After injection, the amount of food intake and acute glycemic variation were assessed for comparison.
In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.
Report a problemFND-3144074804

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:10 UTC
Study results updated
Version 1
9 Oct 2026, 03:05 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.