Reduced skeletal muscle expression of mitochondrial-derived peptides humanin and MOTS-C and Nrf2 in chronic kidney disease.

Liu C, Gidlund EK, Witasp A, Qureshi AR, Söderberg M, Thorell A, Nader GA, Barany P, Stenvinkel P, von Walden F

American journal of physiology. Renal physiology21 Aug 2019Cited by 62 (Europe PMC)

PMID31432706DOI10.1152/ajprenal.00202.2019PepBankPUB-31432706

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

No result from this study comes from a test of the peptide.

Natural levels measured5

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01HumanEndogenous levelObservational studyOther
In patients with stage 5 chronic kidney disease, the body's own MOTS‑c level in skeletal muscle was lower than in controls.
In plain wordsIn people with advanced kidney disease, the body's own MOTS‑c in muscle was lower than in people with normal kidneys.
Peptide
MOTS-c
Outcome
DecreaseMOTS-c level in skeletal muscle
Study
n: not reported in source
Comparator
Age-matched controls with normal renal function
Outcome group
Aging markers · Kidney and urinary
Source sentences
Summary
MOTS-c levels were reduced in both skeletal muscle and serum in CKD.
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated humanin and MOTS-c protein expression in skeletal muscle and serum levels in CKD at stage 5 (glomerular filtration rate: <15 ml/min) patients and age-matched controls with normal renal function.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3143270601
02HumanEndogenous levelObservational studyOther
In patients with stage 5 chronic kidney disease, the body's own MOTS‑c level in serum was lower than in controls.
In plain wordsIn people with advanced kidney disease, the body's own MOTS‑c in blood was lower than in people with normal kidneys.
Peptide
MOTS-c
Outcome
DecreaseMOTS-c level in serum
Study
n: not reported in source
Comparator
Age-matched controls with normal renal function
Outcome group
Aging markers · Kidney and urinary
Source sentences
Summary
MOTS-c levels were reduced in both skeletal muscle and serum in CKD.
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated humanin and MOTS-c protein expression in skeletal muscle and serum levels in CKD at stage 5 (glomerular filtration rate: <15 ml/min) patients and age-matched controls with normal renal function.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3143270602
03HumanEndogenous levelObservational studyOther
In patients with stage 5 chronic kidney disease, circulating humanin levels were increased compared with controls.
In plain wordsIn people with advanced kidney disease, the body's own humanin levels in blood were higher than in controls.
Peptide
Humanin
Outcome
IncreaseCirculating humanin in stage 5 CKD
Study
n: not reported in source
Comparator
Age-matched controls with normal renal function
Outcome group
Aging markers · Kidney and urinary
Source sentences
Summary
Whereas circulating levels of humanin were increased in CKD, local muscle expression was reduced.
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated humanin and MOTS-c protein expression in skeletal muscle and serum levels in CKD at stage 5 (glomerular filtration rate: <15 ml/min) patients and age-matched controls with normal renal function.
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3143270604
04HumanEndogenous levelObservational studyOther
In patients with stage 5 chronic kidney disease, local skeletal muscle humanin expression was reduced compared with controls.
In plain wordsIn people with advanced kidney disease, the body's own humanin in muscle was lower than in controls.
Peptide
Humanin
Outcome
DecreaseSkeletal muscle humanin expression in stage 5 CKD
Study
n: not reported in source
Comparator
Age-matched controls with normal renal function
Outcome group
Aging markers · Kidney and urinary
Source sentences
Summary
Whereas circulating levels of humanin were increased in CKD, local muscle expression was reduced.
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated humanin and MOTS-c protein expression in skeletal muscle and serum levels in CKD at stage 5 (glomerular filtration rate: <15 ml/min) patients and age-matched controls with normal renal function.
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3143270605
05HumanEndogenous levelObservational studyOther
In patients with chronic kidney disease, serum humanin correlated positively with circulating TNF levels.
In plain wordsIn people with advanced kidney disease, higher levels of the body's own humanin in blood were linked to higher TNF.
Peptide
Humanin
Outcome
IncreaseSerum humanin correlation with circulating TNF
Study
n: not reported in source
Outcome group
Inflammation markers · Kidney and urinary
Source sentences
Summary
Humanin in serum correlated positively to circulating TNF levels.
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated humanin and MOTS-c protein expression in skeletal muscle and serum levels in CKD at stage 5 (glomerular filtration rate: <15 ml/min) patients and age-matched controls with normal renal function.
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3143270606

Studies that did not test the peptide alone2

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

06HumanNot a test of MOTS-c aloneObservational studyOther
In patients with chronic kidney disease, reduced muscle levels of mitochondria-derived peptides (humanin and MOTS‑c) were associated with lower mitochondrial density and oxidative stress.
In plain wordsIn people with advanced kidney disease, lower natural levels of these mitochondrial peptides in muscle were linked to fewer mitochondria and more oxidative stress.
Peptide
MOTS-c
Outcome
Not applicableMuscle MDP levels and mitochondrial density
Study
n: not reported in source
Outcome group
Aging markers · Kidney and urinary
Source sentences
Summary
Reduced MDP levels in skeletal muscle were associated with lower mitochondrial density and evidence of oxidative stress.
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated humanin and MOTS-c protein expression in skeletal muscle and serum levels in CKD at stage 5 (glomerular filtration rate: <15 ml/min) patients and age-matched controls with normal renal function.
In this study, MOTS-c was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MOTS-c.
Report a problemFND-3143270603
07HumanNot a test of Humanin aloneObservational studyOther
In chronic kidney disease, reduced skeletal muscle levels of the mitochondria-derived peptides humanin and MOTS-c together were associated with lower mitochondrial density and evidence of oxidative stress.
In plain wordsIn people with advanced kidney disease, lower muscle levels of two mitochondrial peptides, humanin and MOTS-c, were linked to lower mitochondrial density and oxidative stress.
Peptide
Humanin
Outcome
Not applicableMuscle MDP levels and mitochondrial density
Study
n: not reported in source
Outcome group
Mitochondrial function · Kidney and urinary
Source sentences
Summary
Reduced MDP levels in skeletal muscle were associated with lower mitochondrial density and evidence of oxidative stress.
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated humanin and MOTS-c protein expression in skeletal muscle and serum levels in CKD at stage 5 (glomerular filtration rate: <15 ml/min) patients and age-matched controls with normal renal function.
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
Report a problemFND-3143270607

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Versions 4 to 18Current
28 Oct 2026, 02:02 UTC
The same notice was added 15 times, first on 13 Oct 2026, 21:44 UTC. The status did not change between them.
Study results updated
Version 3
13 Oct 2026, 16:31 UTC
Study data updated · source update from Europe PMC
Version 2
10 Oct 2026, 08:19 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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