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Study · Not a test of the peptide alone · 2019

1 result

Synergistic long-range effects of mutations underlie aggregation propensities of amylin analogues.

Alves NA, Dias LG, Frigori RB

Journal of molecular modeling19 Aug 2019Cited by 3 (Europe PMC)

PMID31428870 (opens in a new tab)DOI10.1007/s00894-019-4137-x (opens in a new tab)PepBankPUB-31428870
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone1

In this study, Pramlintide (Symlin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Pramlintide (Symlin).

  1. 01Computer modelNot a test of Pramlintide (Symlin) aloneIn silicoMechanism

    In molecular simulations, pramlintide exhibited a thermal helix-to-sheet conversion channel resembling human amylin.

    In plain wordsComputer simulations showed a thermal helix-to-sheet conversion channel in pramlintide that resembled human amylin.

    Peptide
    Pramlintide (Symlin)
    Outcome
    Not applicableThermal helix-to-sheet conversion channel
    Study

    n: not reported in source

    Replica-exchange molecular dynamics of sIAPP
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    Our thermo-structural analyses show that sIAPP exhibits a thermal conversion channel of helices[Formula: see text]-sheets resembling hIAPP.
    1 context sentence
    Summary · context
    we performed comparative assessments of rIAPP, sIAPP, and sIAPP+ using replica-exchange molecular dynamics (REMD) with an accurate combination of force field Charmm22* and explicit aqueous solvation TIP4P/Ew.

    In this study, Pramlintide (Symlin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Pramlintide (Symlin).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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