Skip to content

Study · Animal study (in vivo) · mouse · 2019

6 results

Carnosine decreases retinal ganglion cell death in a mouse model of optic nerve crushing.

Kim HG, Heo H, Sung MS, Park SW

Neuroscience letters12 Aug 2019Cited by 4 (Europe PMC)

PMID31415801 (opens in a new tab)DOI10.1016/j.neulet.2019.134431 (opens in a new tab)PepBankPUB-31415801
Publisher pagePubMedAsk about this study
Jump to 6 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In mouse retinas after optic nerve crushing, carnosine attenuated PPAR-γ upregulation compared with saline.

    In plain wordsIn mice after optic nerve crushing, carnosine reduced retinal PPAR-γ upregulation compared with saline.

    Peptide
    L-carnosine
    Outcome
    DecreasePPAR-γ expression
    Study

    mousen: not reported in source

    C57BL/6 J mice after optic nerve crushing
    Comparator
    Saline
    Outcome group
    Neuroprotection · Eye
    Studied dose
    250 mg/kg once daily · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    The expression levels of PPAR-γ and GFAP were upregulated in saline-treated retinas for 7 days after ONC, with maximal expression at 3 days, and carnosine treatment effectively attenuated this upregulation.
    1 context sentence
    Summary · context
    C57BL/6 J mice underwent ONC and were treated with carnosine (250 mg/kg) or saline intraperitoneally once daily until sacrifice.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mouse retinas after optic nerve crushing, carnosine attenuated GFAP upregulation compared with saline.

    In plain wordsIn mice after optic nerve crushing, carnosine reduced retinal GFAP upregulation compared with saline.

    Peptide
    L-carnosine
    Outcome
    DecreaseGFAP expression
    Study

    mousen: not reported in source

    C57BL/6 J mice after optic nerve crushing
    Comparator
    Saline
    Outcome group
    Neuroprotection · Eye
    Studied dose
    250 mg/kg once daily · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    The expression levels of PPAR-γ and GFAP were upregulated in saline-treated retinas for 7 days after ONC, with maximal expression at 3 days, and carnosine treatment effectively attenuated this upregulation.
    1 context sentence
    Summary · context
    C57BL/6 J mice underwent ONC and were treated with carnosine (250 mg/kg) or saline intraperitoneally once daily until sacrifice.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mouse retinas after optic nerve crushing, carnosine blocked NF-κB upregulation compared with saline.

    In plain wordsIn mice after optic nerve crushing, carnosine blocked retinal NF-κB upregulation compared with saline.

    Peptide
    L-carnosine
    Outcome
    DecreaseNF-κB expression
    Study

    mousen: not reported in source

    C57BL/6 J mice after optic nerve crushing
    Comparator
    Saline
    Outcome group
    Neuroprotection · Eye
    Studied dose
    250 mg/kg once daily · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    In addition, upregulation of NF-κB, PGC-1α and mtTFA expression was also observed in saline-treated retinas after ONC, and this upregulation was blocked by carnosine treatment, resulting in a significant difference between carnosine-treated and saline-treated retinas after ONC.
    1 context sentence
    Summary · context
    C57BL/6 J mice underwent ONC and were treated with carnosine (250 mg/kg) or saline intraperitoneally once daily until sacrifice.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mouse retinas after optic nerve crushing, carnosine blocked PGC-1α upregulation compared with saline.

    In plain wordsIn mice after optic nerve crushing, carnosine blocked retinal PGC-1α upregulation compared with saline.

    Peptide
    L-carnosine
    Outcome
    DecreasePGC-1α expression
    Study

    mousen: not reported in source

    C57BL/6 J mice after optic nerve crushing
    Comparator
    Saline
    Outcome group
    Neuroprotection · Eye
    Studied dose
    250 mg/kg once daily · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    In addition, upregulation of NF-κB, PGC-1α and mtTFA expression was also observed in saline-treated retinas after ONC, and this upregulation was blocked by carnosine treatment, resulting in a significant difference between carnosine-treated and saline-treated retinas after ONC.
    1 context sentence
    Summary · context
    C57BL/6 J mice underwent ONC and were treated with carnosine (250 mg/kg) or saline intraperitoneally once daily until sacrifice.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mouse retinas after optic nerve crushing, carnosine blocked mtTFA upregulation compared with saline.

    In plain wordsIn mice after optic nerve crushing, carnosine blocked retinal mtTFA upregulation compared with saline.

    Peptide
    L-carnosine
    Outcome
    DecreasemtTFA expression
    Study

    mousen: not reported in source

    C57BL/6 J mice after optic nerve crushing
    Comparator
    Saline
    Outcome group
    Neuroprotection · Eye
    Studied dose
    250 mg/kg once daily · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    In addition, upregulation of NF-κB, PGC-1α and mtTFA expression was also observed in saline-treated retinas after ONC, and this upregulation was blocked by carnosine treatment, resulting in a significant difference between carnosine-treated and saline-treated retinas after ONC.
    1 context sentence
    Summary · context
    C57BL/6 J mice underwent ONC and were treated with carnosine (250 mg/kg) or saline intraperitoneally once daily until sacrifice.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In mice after optic nerve crushing, carnosine protected against retinal ganglion cell loss compared with saline.

    In plain wordsIn mice after optic nerve crushing, carnosine protected against retinal nerve cell loss compared with saline.

    Peptide
    L-carnosine
    Outcome
    DecreaseRetinal ganglion cell loss
    Study

    mousen: not reported in source

    C57BL/6 J mice after optic nerve crushing
    Comparator
    Saline
    Outcome group
    Neuroprotection · Eye
    Studied dose
    250 mg/kg once daily · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Immunohistochemical staining for Brn3a also showed that carnosine treatment protected against RGC loss after ONC.
    1 context sentence
    Summary · context
    C57BL/6 J mice underwent ONC and were treated with carnosine (250 mg/kg) or saline intraperitoneally once daily until sacrifice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.