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Study · Not a test of the peptide alone · 2019

2 results

Metallacarboranes as a tool for enhancing the activity of therapeutic peptides.

Fink K, Boratyński J, Paprocka M, Goszczyński TM

Annals of the New York Academy of Sciences12 Aug 2019Cited by 19 (Europe PMC)

PMID31407357 (opens in a new tab)DOI10.1111/nyas.14201 (opens in a new tab)PepBankPUB-31407357
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 01LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Efficacy outcome

    In an in vitro wound closure assay with MSU1.1 fibroblasts, conjugation of Tβ4 with [COSAN]- enhanced the activity of Tβ4.

    In plain wordsIn cells, thymosin beta‑4 joined to a boron cluster closed a scratch wound better than thymosin beta‑4 alone.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseIn vitro wound closure by fibroblasts
    Study

    n: not reported in source

    MSU1.1 fibroblast wound closure assay
    Comparator
    Unconjugated Tβ4
    Outcome group
    Wound healing · Skin and wound

    Source sentences

    Summary
    Using an in vitro wound closure assay, we showed that conjugation with [COSAN]- enhances the activity of Tβ4 toward fibroblasts (MSU1.1 cell line).
    1 context sentence
    Summary · context
    Here, we conjugated [COSAN]- with the therapeutic peptide thymosin β4 (Tβ4), which has a pleiotropic activity that results in enhanced healing and regeneration of injured tissues.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  2. 02LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cell-free)Activity measurement

    Conjugates of thymosin β4 with cobalt bis(1,2-dicarbollide) showed high affinity for human serum albumin.

    In plain wordsIn lab tests, thymosin beta‑4 joined to a boron cluster bound strongly to the blood protein albumin.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableAffinity of Tβ4-[COSAN] conjugates for human serum albumin
    Study

    n: not reported in source

    Human serum albumin (fluorescence quenching and surface plasmon resonance)
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    Using fluorescence quenching of human serum albumin and surface plasmon resonance techniques, we showed that the conjugates have a high affinity to human serum albumin.
    1 context sentence
    Summary · context
    Here, we conjugated [COSAN]- with the therapeutic peptide thymosin β4 (Tβ4), which has a pleiotropic activity that results in enhanced healing and regeneration of injured tissues.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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