Identification of a prosurvival neuroprotective mitochondrial peptide in a mammalian hibernator.

Szereszewski KE, Storey KB

Cell biochemistry and function6 Aug 2019Cited by 12 (Europe PMC)

PMID31387137DOI10.1002/cbf.3422PepBankPUB-31387137

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Natural levels measured5

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01AnimalEndogenous levelAnimal study (in vivo)Other
In hibernating 13-lined ground squirrels, s-humanin transcript levels increased in brain cortex during hibernation.
In plain wordsIn hibernating ground squirrels, the body's own s-humanin gene activity rose in the brain cortex.
Peptide
Humanin
Outcome
Increases-humanin transcript level in brain cortex during hibernation
Study
13-lined ground squirrel (Ictidomys tridecemlineatus)n: not reported in source
Comparator
Non-hibernating state
Outcome group
Mitochondrial function · Whole body
Source sentences
Summary
transcript levels increased in brain cortex, skeletal muscle, and adipose tissues during hibernation
1 context sentence(design, population, supporting numbers)
Summary · context
Herein, we report the presence of a novel mitochondrial peptide, s-humanin, in the hibernating 13-lined ground squirrel, Ictidomys tridecemlineatus.
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3138713701
02AnimalEndogenous levelAnimal study (in vivo)Other
In hibernating 13-lined ground squirrels, s-humanin transcript levels increased in skeletal muscle during hibernation.
In plain wordsIn hibernating ground squirrels, the body's own s-humanin gene activity rose in skeletal muscle.
Peptide
Humanin
Outcome
Increases-humanin transcript level in skeletal muscle during hibernation
Study
13-lined ground squirrel (Ictidomys tridecemlineatus)n: not reported in source
Comparator
Non-hibernating state
Outcome group
Mitochondrial function · Whole body
Source sentences
Summary
transcript levels increased in brain cortex, skeletal muscle, and adipose tissues during hibernation
1 context sentence(design, population, supporting numbers)
Summary · context
Herein, we report the presence of a novel mitochondrial peptide, s-humanin, in the hibernating 13-lined ground squirrel, Ictidomys tridecemlineatus.
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3138713702
03AnimalEndogenous levelAnimal study (in vivo)Other
In hibernating 13-lined ground squirrels, s-humanin transcript levels increased in adipose tissue during hibernation.
In plain wordsIn hibernating ground squirrels, the body's own s-humanin gene activity rose in fat tissue.
Peptide
Humanin
Outcome
Increases-humanin transcript level in adipose tissue during hibernation
Study
13-lined ground squirrel (Ictidomys tridecemlineatus)n: not reported in source
Comparator
Non-hibernating state
Outcome group
Mitochondrial function · Whole body
Source sentences
Summary
transcript levels increased in brain cortex, skeletal muscle, and adipose tissues during hibernation
1 context sentence(design, population, supporting numbers)
Summary · context
Herein, we report the presence of a novel mitochondrial peptide, s-humanin, in the hibernating 13-lined ground squirrel, Ictidomys tridecemlineatus.
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3138713703
04AnimalEndogenous levelAnimal study (in vivo)Other
In torpid 13-lined ground squirrels, s-humanin peptide levels were suppressed in liver.
In plain wordsIn torpid ground squirrels, the body's own s-humanin peptide levels were lower in the liver.
Peptide
Humanin
Outcome
Decreases-humanin peptide level in liver of torpid squirrels
Study
13-lined ground squirrel (Ictidomys tridecemlineatus)n: not reported in source
Comparator
Non-hibernating state
Outcome group
Mitochondrial function · Whole body
Source sentences
Summary
Accompanying peptide measurements found that s-humanin levels were suppressed in liver of torpid squirrels but enhanced in brain cortex.
1 context sentence(design, population, supporting numbers)
Summary · context
Herein, we report the presence of a novel mitochondrial peptide, s-humanin, in the hibernating 13-lined ground squirrel, Ictidomys tridecemlineatus.
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3138713704
05AnimalEndogenous levelAnimal study (in vivo)Other
In torpid 13-lined ground squirrels, s-humanin peptide levels were enhanced in brain cortex.
In plain wordsIn torpid ground squirrels, the body's own s-humanin peptide levels were higher in the brain cortex.
Peptide
Humanin
Outcome
Increases-humanin peptide level in brain cortex of torpid squirrels
Study
13-lined ground squirrel (Ictidomys tridecemlineatus)n: not reported in source
Comparator
Non-hibernating state
Outcome group
Mitochondrial function · Whole body
Source sentences
Summary
Accompanying peptide measurements found that s-humanin levels were suppressed in liver of torpid squirrels but enhanced in brain cortex.
1 context sentence(design, population, supporting numbers)
Summary · context
Herein, we report the presence of a novel mitochondrial peptide, s-humanin, in the hibernating 13-lined ground squirrel, Ictidomys tridecemlineatus.
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3138713705

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

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