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Study · In vitro (cell-free) · mouse · 2019

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Carnosine Mitigates Manganese Mitotoxicity in an In Vitro Model of Isolated Brain Mitochondria.

Ghanbarinejad V, Ahmadi A, Niknahad H, Ommati MM, Heidari R

Advanced pharmaceutical bulletin1 Jun 2019Cited by 12 (Europe PMC)

PMID31380256 (opens in a new tab)PMCIDPMC6664115 (opens in a new tab)DOI10.15171/apb.2019.034 (opens in a new tab)PepBankPUB-31380256
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Summary

Purpose: Manganese (Mn) is a neurotoxic chemical which induces a wide range of complications in the brain tissue. Impaired locomotor activity and cognitive dysfunction are associated with high brain Mn content. At the cellular level, mitochondria are potential targets for Mn toxicity. Carnosine is a dipeptide abundantly found in human brain. Several pharmacological properties including mitochondrial protecting and antioxidative effects have been attributed to carnosine. The current study aimed to evaluate the effect of carnosine treatment on Mn-induced mitochondrial dysfunction in isolated brain mitochondria. Methods: Mice brain mitochondria were isolated based on the differential centrifugation method and exposed to increasing concentrations of Mn (10 µM-10 mM). Carnosine (1 mM) was added as the protective agent. Mitochondrial indices including mitochondrial depolarization, reactive oxygen species (ROS) formation, mitochondrial dehydrogenases activity, ATP content, and mitochondrial swelling and permeabilization were assessed. Results: Significant deterioration in mitochondrial indices were evident in Mn-exposed brain mitochondria. On the other hand, it was found that carnosine (1 mM) treatment efficiently prevented Mn-induced mitochondrial impairment. Conclusion: These data propose mitochondrial protection as a fundamental mechanism for the effects of carnosine against Mn toxicity. Hence, this peptide might be applicable against Mn neurotoxicity with different etiologies (e.g., in cirrhotic patients).
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cell-free)Efficacy outcome

    In isolated mouse brain mitochondria, carnosine prevented manganese-induced mitochondrial impairment.

    In plain wordsIn lab tests with mouse brain mitochondria, carnosine prevented manganese-induced mitochondrial impairment.

    Peptide
    L-carnosine
    Outcome
    DecreaseMitochondrial impairment
    Study

    mousen: not reported in source

    Isolated brain mitochondria exposed to manganese
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    1 mMAs given in this study (mouse).

    Source sentences

    Summary
    On the other hand, it was found that carnosine (1 mM) treatment efficiently prevented Mn-induced mitochondrial impairment.
    2 context sentences
    Summary · context
    Mice brain mitochondria were isolated based on the differential centrifugation method and exposed to increasing concentrations of Mn (10 µM-10 mM).
    Summary · context
    Carnosine (1 mM) was added as the protective agent.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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