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Study · Animal study (in vivo) · mouse · 2020

9 results

Targeting cell membrane HDM2: A novel therapeutic approach for acute myeloid leukemia.

Wang H, Zhao D, Nguyen LX, Wu H, Li L, Dong D, Troadec E, Zhu Y, Hoang DH, Stein AS, Al Malki M, Aldoss I and 9 more

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Lin A, Ghoda LY, McDonald T, Pichiorri F, Carlesso N, Kuo YH, Zhang B, Jin J, Marcucci G

Leukemia23 Jul 2019Cited by 14 (Europe PMC)

PMID31337857 (opens in a new tab)PMCIDPMC7951797 (opens in a new tab)DOI10.1038/s41375-019-0522-9 (opens in a new tab)PepBankPUB-31337857
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In human and murine AML models, PNC‑27 significantly killed bulk AML blasts in primary transplant experiments.

    In plain wordsIn mice with human or mouse leukemia, PNC‑27 killed bulk leukemia blasts in primary transplant experiments.

    Peptide
    PNC-27
    Outcome
    IncreaseBulk AML blast killing
    Study

    mousen: not reported in source

    human and murine AML transplant models
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    PNC-27 treatment in vivo resulted in a significant killing of both AML "bulk" blasts and LSCs, as demonstrated respectively in primary and secondary transplant experiments, using both human and murine AML models.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In human and murine AML models, PNC‑27 significantly killed leukemia stem cells in secondary transplant experiments.

    In plain wordsIn mice with human or mouse leukemia, PNC‑27 killed leukemia stem cells in secondary transplant experiments.

    Peptide
    PNC-27
    Outcome
    IncreaseLeukemia stem cell killing
    Study

    mousen: not reported in source

    human and murine AML transplant models
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    PNC-27 treatment in vivo resulted in a significant killing of both AML "bulk" blasts and LSCs, as demonstrated respectively in primary and secondary transplant experiments, using both human and murine AML models.
  3. 03AnimalAnimal study (in vivo)Safety outcome

    In wild-type mice, PNC‑27 spared normal hematopoietic stem cell activity in primary and secondary bone marrow transplant experiments.

    In plain wordsIn mice, PNC‑27 spared normal blood stem cell activity in primary and secondary bone marrow transplant experiments.

    Peptide
    PNC-27
    Outcome
    Not applicableNormal hematopoietic stem cell activity
    Study

    mousen: not reported in source

    wild-type mouse bone marrow transplant experiments
    Outcome group
    Adverse events · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Notably, PNC-27 spares normal HSC activity, as demonstrated in primary and secondary BM transplant experiments of wild-type mice.
  4. 04LabIn vitro (cells)Mechanism

    In AML blasts, PNC‑27 bound to membrane HDM2.

    In plain wordsIn cells, PNC‑27 bound to membrane HDM2 in leukemia blasts.

    Peptide
    PNC-27
    Outcome
    Not applicableMembrane HDM2 binding
    Study

    n: not reported in source

    AML blasts
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We also showed that a synthetic peptide PNC-27 binds to mHDM2 and enhances the interaction of mHDM2 and E-cadherin on the cell membrane;
  5. 05LabIn vitro (cells)Mechanism

    In AML blasts, PNC‑27 enhanced the interaction between membrane HDM2 and E-cadherin.

    In plain wordsIn cells, PNC‑27 increased the interaction between membrane HDM2 and E-cadherin.

    Peptide
    PNC-27
    Outcome
    IncreaseHDM2 and E-cadherin interaction
    Study

    n: not reported in source

    AML blasts
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We also showed that a synthetic peptide PNC-27 binds to mHDM2 and enhances the interaction of mHDM2 and E-cadherin on the cell membrane;
  6. 06LabIn vitro (cells)Mechanism

    In AML blasts, PNC‑27-mediated membrane interactions involved E-cadherin ubiquitination.

    In plain wordsIn cells, PNC‑27-mediated interactions involved E-cadherin tagging.

    Peptide
    PNC-27
    Outcome
    Not applicableE-cadherin ubiquitination
    Study

    n: not reported in source

    AML blasts
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We also showed that a synthetic peptide PNC-27 binds to mHDM2 and enhances the interaction of mHDM2 and E-cadherin on the cell membrane; in turn, E-cadherin ubiquitination and degradation lead to membrane damage and cell death of AML blasts by necrobiosis.
  7. 07LabIn vitro (cells)Mechanism

    In AML blasts, PNC‑27-mediated interactions led to membrane damage.

    In plain wordsIn cells, PNC‑27-mediated interactions damaged leukemia cell membranes.

    Peptide
    PNC-27
    Outcome
    IncreaseMembrane damage
    Study

    n: not reported in source

    AML blasts
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We also showed that a synthetic peptide PNC-27 binds to mHDM2 and enhances the interaction of mHDM2 and E-cadherin on the cell membrane; in turn, E-cadherin ubiquitination and degradation lead to membrane damage and cell death of AML blasts by necrobiosis.
  8. 08LabIn vitro (cells)Efficacy outcome

    In AML blasts, PNC‑27-mediated interactions led to cell death by necrobiosis.

    In plain wordsIn cells, PNC‑27-mediated interactions killed leukemia blasts by necrobiosis.

    Peptide
    PNC-27
    Outcome
    IncreaseCell death by necrobiosis
    Study

    n: not reported in source

    AML blasts
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We also showed that a synthetic peptide PNC-27 binds to mHDM2 and enhances the interaction of mHDM2 and E-cadherin on the cell membrane; in turn, E-cadherin ubiquitination and degradation lead to membrane damage and cell death of AML blasts by necrobiosis.
  9. 09LabIn vitro (cells)Mechanism

    In AML blasts, PNC‑27-mediated membrane interactions involved E-cadherin degradation.

    In plain wordsIn cells, PNC‑27-mediated interactions involved E-cadherin breakdown.

    Peptide
    PNC-27
    Outcome
    Not applicableE-cadherin degradation
    Study

    n: not reported in source

    AML blasts
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We also showed that a synthetic peptide PNC-27 binds to mHDM2 and enhances the interaction of mHDM2 and E-cadherin on the cell membrane; in turn, E-cadherin ubiquitination and degradation lead to membrane damage and cell death of AML blasts by necrobiosis.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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